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Your search keyword '"Castilla, Lucio H."' showing total 2 results
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1. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11

Author

Castilla, Lucio H., Wijmenga, Cisca, Wang, Qing, Stacy, Terryl, Speck, Nancy A., Eckhaus, Michael, Marin-Padilla, Miguel, Collins, Francis, Wynshaw-Boris, Anthony, and Liu, Pu P.

Subjects
Hematopoiesis -- Research, Mouse leukemia complex -- Genetic aspects, Hemorrhage -- Genetic aspects, Hematopoietic stem cells -- Analysis, Biological sciences
Abstract

The CBFB-MYH11 gene was introduced into mouse genome by inserting the 3' part of the human MYH11 cDNA into the end of exon 5 of the mouse Cbfb gene through homologous recombination. This led to the creation of a half genomic (Cbfb), half cDNA (MYH11) fusion gene, which, in turn, resulted in the generation of a Cbf(beta)-SMMHC fusion protein under the control of the Cbfb promoter. Cbf(beta)-SMMHC is shown to dominantly suppress the normal function of Cbf gene products and inhibits the differentiation of hematopoietic stem cells.

Published
1996

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