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1. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1

Author

Schindler, Michael; Munch, Jan; Kutsch, Olaf, Santiago, Mario L.; Bibollet-Ruche, Frederic; Muller-Trutwin, Michaela C., Novembre, Francis J.; Peeters, Martine; Courgnaud, Valerie, Bailes, Elizabeth; Roques, Pierre; Sodora, Donald L., and Silvestri, Guido; Sharp, Paul M.; Hahn, Beatrice H.; Kirchhoff, Frank; Hui Li

Subjects
T cells -- Research, Allelomorphism -- Research, Primates -- Genetic aspects, Biological sciences
Abstract

A study reports that nef alleles from the great majority of primate lentiviruses, including human immunodeficiency virus-2 (HIV-2), down-modulate TCR-CD3 from infected T cells, thereby blocking their responsiveness to activation. It concludes that Nef exerts a protective function which was lost during lentiviral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans.

Published
2006

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