1. A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy
- Author
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Nakada, Yasuyuki, Tsuboi, Nobuo, Takahashi, Yasuto, Yoshida, Hiraku, Hara, Yoriko, Okonogi, Hideo, Kawamura, Tetsuya, Arimura, Yoshihiro, and Yokoo, Takashi
- Subjects
Article Subject ,cardiovascular diseases ,urologic and male genital diseases - Abstract
We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.
- Published
- 2015
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