1. Severe Periodontal Disease Associated with Long-Term Treatment with Intravenous Immunoglobulin
- Author
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Jôice Dias Corrêa, Amanda Leal Rocha, Lidiane Cristina Machado Costa, Denise Travassos, Wagner Henriques Castro, Gustavo Pompermaier Garlet, Rodrigo Santiago Gomez, Antônio Lúcio Teixeira, and Tarcília Aparecida Silva
- Subjects
Dentistry ,RK1-715 - Abstract
Intravenous immunoglobulin (IVIG) is used in the treatment of neuropathy. This case report presents, for the first time, a patient with severe periodontal destruction after chronic therapy with IVIG. The patient reported having extracted his maxillary anterior teeth himself due to high mobility. Clinical examination and radiographic images show a generalized and severe periodontitis. No significant alterations in genetic or microbiological features were observed. The present case suggests that periodontal disease aggravation could be considered a new adverse effect of IVIG therapy. Postulated mechanisms are immune complexes formation, complement activation, and a direct effect in osteoclasts. In conclusion, it is important that patients that will receive IVIG treatment underwent dental evaluation.
- Published
- 2014
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