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The positive inotropic and chronotropic effect of salbutamol is significantly different from that of either orciprenaline or isoprenaline. Unlike orciprenaline, salbutamol neither reduces the ratio between the useful mechanical work performed by the heart and the oxygen expended in performing that work, nor does it deplete the cardiac stores of adenosine tri- and creatine-phosphate. [ABSTRACT FROM PUBLISHER]

The effect of the anti-hypertensive drug, Catapres, on coronary vascular resistance and myocardial oxygen consumption was studied. Catapres lowered coronary vascular resistance by a direct and an indirect action. The indirect coronary vasodilator effect may result from a central action of the drug and is not associated with an increase in myocardial oxygen consumption. [ABSTRACT FROM PUBLISHER]

The addition of equipotent β-blocking doses of the adrenergic β-receptor blocking compounds KÖ 592, Ciba 39,089-Ba, and MJ 1999 to dog-heart-lung bypass preparations results in an increased resistance to blood flow in the coronary circulation, and a decreased resistance to flow in the inferior and superior venae cavae. These effects resemble those caused by propranolol and cannot be explained simply in terms of adrenergic β-receptor blockade. [ABSTRACT FROM PUBLISHER]