1. Hypertensive left ventricular remodeling and ACE-gene polymorphism.
- Author
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Perticone F, Maio R, Cosco C, Ceravolo R, Iacopino S, Chello M, Mastroroberto P, Tramontano D, and Mattioli PL
- Subjects
- Age Factors, Analysis of Variance, Evaluation Studies as Topic, Female, Genotype, Humans, Hypertension genetics, Linear Models, Male, Middle Aged, Risk Factors, Sex Factors, Hypertension pathology, Peptidyl-Dipeptidase A genetics, Polymorphism, Genetic, Ventricular Remodeling
- Abstract
Objective: To evaluate the relationship between ACE-gene polymorphism and left ventricular geometry in never treated hypertensives., Methods: We enrolled 200 hypertensive outpatients that underwent clinical and ambulatory blood pressure measurements, echocardiographic evaluation and analysis for insertion (I)/deletion (D) polymorphism by PCR. Patients with normal or increased (> 125 g/m2 in males and > 110 g/m2 in females) left ventricular mass were considered to have concentric remodeling or concentric left ventricular hypertrophy if their relative wall thickness was > or = 0.45., Results: The left ventricular mass index values (g/m2) were 136 +/- 30 in DD genotype, 124 +/- 26 in ID genotype, and 116 +/- 20 in II genotype (DD vs. ID P < 0.005; DD vs. II P < 0.05), and were unrelated to blood pressure. Ninety-six patients presented left ventricular hypertrophy (48.0%): 51 with concentric and 45 with eccentric hypertrophy. The eccentric left ventricular hypertrophy was detected in 32 (36.8%) DD patients, in ten (10.5%) ID patients (P < 0.05), and in three (16.6%) II patients. The relative septal thickness was 0.43 +/- 0.09 in DD genotype, 0.45 +/- 0.08 in ID genotype, and 0.43 +/- 0.10 in II genotype. In DD and ID genotypes, the relative posterior wall thickness (0.37 +/- 0.07 vs. 0.41 +/- 0.07; P < 0.0001) and the end-diastolic left ventricular internal dimension (52.8 +/- 3.3 mm vs. 48.3 +/- 2.8 mm; P < 0.0001) were statistically different., Conclusions: The DD genotype of the ACE-gene is associated with an increased left ventricular mass and with a significantly higher prevalence of eccentric left ventricular hypertrophy, when compared to ID genotype.
- Published
- 1999
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