1. Cellular and molecular mechanisms of sex differences in renal ischemia–reperfusion injury
- Author
-
Meijing Wang, Ben M. Tsai, Ajay Kher, Jeffrey M. Pitcher, Daniel R. Meldrum, and Kirstan K. Meldrum
- Subjects
Graft Rejection ,Pathology ,medicine.medical_specialty ,Physiology ,Ischemia ,Kidney ,urologic and male genital diseases ,Physiology (medical) ,medicine ,Animals ,Transplantation, Homologous ,Kidney transplantation ,Sex Characteristics ,business.industry ,Acute kidney injury ,Acute Kidney Injury ,medicine.disease ,Kidney Transplantation ,Transplantation ,medicine.anatomical_structure ,Reperfusion Injury ,Cardiology and Cardiovascular Medicine ,business ,Reperfusion injury ,Kidney disease ,Sex characteristics - Abstract
Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARF. In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury.
- Published
- 2005
- Full Text
- View/download PDF