1. 2-Arachidonoyl glycerol induces contraction of isolated rat aorta: role of cyclooxygenase-derived products
- Author
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Michel Mallaret, Françoise Stanke-Labesque, Germain Bessard, Gaëlle Hardy, Blandine Lefebvre, and Françoise Caron
- Subjects
Male ,medicine.medical_specialty ,Contraction (grammar) ,Vascular smooth muscle ,Physiology ,Thromboxane ,Arachidonic Acids ,In Vitro Techniques ,Dinoprost ,Rats, Inbred WKY ,Dinoprostone ,Muscle, Smooth, Vascular ,Glycerides ,Thromboxane A2 ,chemistry.chemical_compound ,Physiology (medical) ,Internal medicine ,medicine.artery ,Cannabinoid Receptor Modulators ,medicine ,Cannabinoid receptor type 2 ,Animals ,Vasoconstrictor Agents ,Aorta ,Chemistry ,Transport inhibitor ,Rats ,Endocrinology ,Biochemistry ,Prostaglandin-Endoperoxide Synthases ,cardiovascular system ,lipids (amino acids, peptides, and proteins) ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Vasoconstriction ,Endocannabinoids - Abstract
Objectives: Endocannabinoids have been shown to play a role in the regulation of vascular tone. The effects of 2-arachidonoyl glycerol (2-AG) on induced-tone were examined in rat aortic rings in vitro. Methods: Aortic rings from Wistar Kyoto (WKY) rats were suspended in organ chambers for recording isometric tension development in response to 2-AG. The production of TXA2 in response to 2-AG was also assessed by enzyme immunoassay. Results: In endothelium-intact rings pre-contracted to PGF2α, 2-AG (10 nM–30 μM) induced a biphasic effect: a weak relaxation from 10 nM to 0.1 μM, which turned into a concentration-dependent contraction from 3 to 30 μM. Endothelium-denudation did not change 2-AG-mediated vascular effects. 2-AG-induced contraction was unaffected by both the cannabinoid CB1 receptor antagonist SR141716A (3 μM) and the CB2 receptor antagonist SR144528 (1 μM). In contrast, the anandamine transport inhibitor (AM404, 100 μM) and the amino hydrolase inhibitor (PMSF, 30 μM) attenuated ( P
- Published
- 2004