1. Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study
- Author
-
Young Ju Choi, Seok Won Park, Yong Ho Lee, Eun Jig Lee, Hyeok Hee Lee, Byung Wook Huh, Yongin Cho, Kap Bum Huh, Eun Seok Kang, Byung Wan Lee, and Bong Soo Cha
- Subjects
Adult ,Carotid Artery Diseases ,Liver Cirrhosis ,Male ,lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,Time Factors ,Seoul ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Carotid Intima-Media Thickness ,Risk Assessment ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Fibrosis ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Non-alcoholic steatohepatitis ,Aged ,Original Investigation ,business.industry ,Fatty liver ,Middle Aged ,Prognosis ,Atherosclerosis ,medicine.disease ,Metabolic syndrome ,Diabetes Mellitus, Type 2 ,lcsh:RC666-701 ,Disease Progression ,Female ,030211 gastroenterology & hepatology ,Steatohepatitis ,Steatosis ,Cardiology and Cardiovascular Medicine ,Hepatic fibrosis ,business ,Non-alcoholic fatty liver disease - Abstract
Background There is increasing concern regarding cardiovascular risk in individuals with non-alcoholic fatty liver disease. This study was conducted to evaluate whether hepatic steatosis with or without fibrosis is associated with the progression of carotid atherosclerosis in patients with type 2 diabetes. Methods From a longitudinal cohort, we enrolled 1120 patients with type 2 diabetes who underwent repeated carotid artery ultrasonography every 1–2 years. Ultrasonographic findings at baseline and after 6–8 years were compared. Presence of hepatic steatosis was mainly assessed by abdominal ultrasonography; patients with hepatic steatosis were further evaluated for hepatic fibrosis according to fibrosis-4 index. We investigated the association between liver status and atherosclerosis progression. Results Of 1120 patients, 636 (56.8%) were classified as having hepatic steatosis at baseline. After 6–8 years, 431 (38.5%) showed atherosclerosis progression. Hepatic steatosis was significantly associated with atherosclerosis progression (adjusted odds ratio[AOR]: 1.370, 95% CI 1.025–1.832; p p p p Conclusions Hepatic steatosis with fibrosis is independently associated with the progression of carotid atherosclerosis in patients with type 2 diabetes.
- Published
- 2020