1. Diabetic hyperglycemia attenuates sympathetic dysfunction and oxidative stress after myocardial infarction in rats
- Author
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Christiane Malfitano, Renata Kelly da Palma, Maria Claudia Irigoyen, Cristiano Mostarda, Camila Paixão dos Santos, Sarah Cristina Ferreira Freitas, Susana Llesuy, Adriane Belló-Klein, Catarina de Andrade Barboza, Kátia De Angelis, and Bruno Rodrigues
- Subjects
Male ,medicine.medical_specialty ,Otras Ciencias Biológicas ,Endocrinology, Diabetes and Metabolism ,Myocardial Infarction ,Ischemia ,medicine.disease_cause ,Hiperglicemia ,Antioxidants ,Streptozocin ,Diabetes Mellitus, Experimental ,Diabetic hyperglycemia ,purl.org/becyt/ford/1 [https] ,Ciencias Biológicas ,chemistry.chemical_compound ,Diabetes mellitus ,Estresse oxidativo ,Internal medicine ,medicine ,Animals ,Myocardial infarction ,Rats, Wistar ,purl.org/becyt/ford/1.6 [https] ,Autonomic modulation ,Original Investigation ,chemistry.chemical_classification ,Reactive oxygen species ,business.industry ,Infarto do miocárdio ,Glutathione ,medicine.disease ,Streptozotocin ,Oxidative Stress ,Endocrinology ,chemistry ,Oxidative stress ,Coronary occlusion ,Hyperglycemia ,Reactive Oxygen Species ,Cardiology and Cardiovascular Medicine ,business ,CIENCIAS NATURALES Y EXACTAS ,medicine.drug - Abstract
Background: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Male Wistar rats were divided into: control (C), diabetic (D), myocardial infarcted (MI) and diabetic infarcted rats (DMI). Methods: Diabetes was induced by streptozotocin (STZ, 50 mg/Kg) at the beginning of the protocol and MI was induced by left coronary occlusion 15 days after STZ. Thirty days after streptozocin-induced diabetes, cardiovascular autonomic modulation was evaluated by spectral analysis, and oxidative stress profile was determined by antioxidant enzyme activities and superoxide anion, together with protein carbonylation and redox balance of glutathione (GSH/GSSG). Results: The diabetic and infarcted groups showed decreased heart rate variability and vagal modulation (p
- Published
- 2014