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Start Over Descriptor "beta-blocker therapy" Journal cardiology journal
2 results on '"beta-blocker therapy"'

1. Effects of age on aerobic capacity in heart failure patients under beta-blocker therapy: Possible impact in clinical decision-making?

Author

Emmanuel Gomes Ciolac, Guilherme Veiga Guimarães, Aline Cristina Tavares, Miguel Morita Fernandes da Silva, Edimar Alcides Bocchi, Iram Soares Teixeira-Neto, Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)

Subjects
Adult, Male, medicine.medical_specialty, Heart disease, Adrenergic beta-Antagonists, heart failure, Ventricular Function, Left, Decision Support Techniques, Young Adult, Oxygen Consumption, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, beta-blocker therapy, Treadmill, Aerobic capacity, Aged, Retrospective Studies, Aged, 80 and over, Heart Failure, Analysis of Variance, cardiorespiratory fitness, Exercise Tolerance, Ejection fraction, business.industry, aging, Age Factors, VO2 max, Stroke Volume, Cardiorespiratory fitness, General Medicine, Stroke volume, Middle Aged, medicine.disease, Treatment Outcome, Heart failure, Exercise Test, Linear Models, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, human activities, cardiopulmonary exercise test
Abstract

Made available in DSpace on 2015-03-18T15:56:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Background: Heart failure (HF) is associated with impaired maximal aerobic capacity as indicated by decreases in peak oxygen uptake (peak VO2). Considering that aging by itself has a negative effect on this variable, the evaluation of maximum capacity is often questioned because current predicted peak VO2 is based on subjects without heart disease or beta-blocker therapy. In contrast, if decline in predicted and attained peak VO2 were age-related, proportionally, loss of aerobic function (predicted peak VO2, %) would remain stable over time in these patients. The purpose of this investigation is to assess the effects of age on peak VO2 in HF patients taking beta-blockers.Methods: We retrospectively evaluated 483 (132 female) patients (aged 20-88 years, LVEF 31 +/- 11%) with non-ischemic (n = 362), ischemic (n = 74) and Chagas-related HF (n = 47) who had been submitted to an incremental cardiopulmonary exercise testing on a motorized treadmill. Linear regression was used to develop the equation to predict peak VO2, based on age.Results: Peak VO2 decreased 0.9 mL/min/kg per age-decade, maximum HR also decreased with aging and VE/VCO2 slope was similar among all decades. The predicted new beta-blocker equation to peak VO2bb was 20.934 - 0.092 x age.Conclusions: Clinical interpretation of aerobic capacity impairment is influenced by aging in HF patients. This evidence must be considered when using peak VO2 for prognostic stratification and clinical decision-making in patients with HF under beta-blocker therapy. Sao Paulo State Univ, UNESP, Sch Sci, Exercise & Chron Dis Res Lab,Phys Educ Dept, Bauru, Brazil Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst InCor, Sao Paulo, Brazil Sao Paulo State Univ, UNESP, Sch Sci, Exercise & Chron Dis Res Lab,Phys Educ Dept, Bauru, Brazil FAPESP: 10/08554-7 FAPESP: 12/02409-0 CNPq: 304733/2008-3

Published
2013
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2. Predisposing factors for late mortality in heart transplant patients.

Author

Alyaydin E, Welp H, Reinecke H, and Tuleta I

Subjects
Causality, Humans, Retrospective Studies, Heart Diseases, Heart Failure diagnosis, Heart Transplantation adverse effects
Abstract

Background: Because of the growing prevalence of terminal heart failure on the one hand and organ shortage on the other hand, an optimal care of heart transplant recipients based on the knowledge of potential risk factors not only early, but also in a long-term course after heart transplantation is of great importance. Therefore, the aim of the present study was to identify predisposing factors for late mortality in this patient collective., Methods: Data from long-term heart transplant patients collected during follow-up visits in the current center were retrospectively analyzed. Clinical, laboratory, including immune monitoring and apparative examination results were studied with regard to all-cause mortality., Results: One hundred and seventy-two patients after heart transplantation (mean: 13.2 ± 6.4 years) were divided into two groups: survivors (n = 133) and non-survivors (n = 39). In comparison with survivors, non-survivors were characterized by significantly more pronounced renal insufficiency with more frequent dialysis, anemia and worse functional status. Additionally, non-survivors obtained hearts from relevantly more obese donors. In a multivariate Cox regression analysis the following parameters were shown to be independent risk factors for increased mortality: CD4 percentage < 42%, C-reactive protein ≥ 0.5 mg/dL, presence of rejections requiring therapies in the past, onset of cardiac allograft vasculopathy < 5 years following heart transplantation and no use of beta-blockers., Conclusions: Low CD4+ cell percentages, sustained inflammation, relevant organ rejections, early onset of transplant vasculopathy and no use of beta-blockers are risk factors for higher mortality in a long-term follow-up after heart transplantation.

Published
2021
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