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1. Role of Adrenal Androgens in the Development of Arteriosclerosis as Judged by Pulse Wave Velocity and Calcification of the Aorta

Author

Fujiki Ishihara, Satoshi Shigematsu, Akihiro Niwa, Kunihide Hiramatsu, Nobuyuki Takasu, Toru Aizawa, Takashi Yamada, and Koichi Matsuo

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Arteriosclerosis, medicine.drug_class, Dehydroepiandrosterone, Aorta, Thoracic, chemistry.chemical_compound, Dehydroepiandrosterone sulfate, Internal medicine, medicine.artery, Adrenal Glands, medicine, Humans, Pharmacology (medical), Pulse wave velocity, Aged, Aged, 80 and over, Aorta, Dehydroepiandrosterone Sulfate, business.industry, Cholesterol, Calcinosis, Middle Aged, Androgen, medicine.disease, Endocrinology, chemistry, Androgens, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity, Calcification
Abstract

To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with age in both sexes, and the reduction was significantly steeper in younger (or = 40 years) than in older (40 years) subjects only in females. When adjusted for age, the steroids were significantly lower in subjects with aortic calcification than in those without it, and the PWV was significantly slower in the latter. Adrenal androgens appear to retard the development and/or progression of arteriosclerosis.

Published
1992
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2. Contents, Vol. 80, 1992

Author

B. Eber, W. Klein, Annie Barratt, Gastone Leonetti, Kunihide Hiramatsu, Y. Sato, G.F. Levi, Victor J. Ferrans, Jens Berning, Mark N. Allen, A. Owen, Yoram Levo, Samuel Sclarovsky, O. Luha, H. Toplak, Yaacov Drory, Guillermo Soriano, Yau-Ting Tai, Tetsuro Sugiura, Takashi Yamada, Enrique Z. Fisman, P. Marino, Anna Rosa Cavallini, A. Quadri, Wulin Aerbajinai, T. Tsujibayashi, Toru Aizawa, Aviv Mager, A. Tiran, S. Marangoni, Paolo Gilli, H. Itoh, S. Trotter, Nobuyuki Takasu, M. Schena, Renato Bragato, A. Koike, Seishi Nakamura, Shunnosuke Honda, Laura Lonati, Yasuo Takayama, S. Scalvini, Bruno Bagni, Francesco Portaluppi, Eldad Rechavia, R. Gasser, Ildefonso Echánove, L. Zanolla, Satoshi Shigematsu, Noritaka Tarumi, Richard S. Meltzer, L. Rossi, William MacNee, Gian Paolo Bezante, Ricardo Beigelman, Maria Cruz Torregrosa, Lorena Sampieri, Cesare Cuspidi, Satoshi Ogawa, Per Eliasen, Arnon Blum, Toshiji Iwasaka, David Harpaz, S. Nakamura, Mitsuo Inada, Jeppe Launbjerg, Yutaka Kimura, K M Skwarski, José Milei, Graciela Fernandez Alonso, Luciana Vergnani, Hisato Nakamori, Silvia Vanzulli, Francisco Ridocci, Monica Bocciolone, K. Taniguchi, Aurelio Quesada, M. Volterrani, Rafael Payá, M. Schumacher, Akihiro Niwa, John Po-Shan Li, Per Fruergaard, Giovanni Tarroni, Bo Gullberg, Koichi Matsuo, Lea Boselli, Fujiki Ishihara, Amos Pines, Jan J. Kellermann, Bengt W. Johansson, Merete Appleyard, Ping-Ching Fong, Ole Hansen, Alberto Zanchetti, José A. De Velasco, Kathy Lai-Fun Lee, Shinya Goto, E. Carbonieri, Daniel Ayalon, Chu-Pak Lau, Knut Borch-Johnsen, Pia Eiken, Loris Montanari, Ettore C. degli Uberti, Michael Motro, P. Zardini, Ruben Storino, Joseph Shemesh, Yochai Birnbaum, and Boris Strasberg

Subjects
Traditional medicine, business.industry, Medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business
Published
1992
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3. Inappropriate Elevation of the Aldosterone/Plasma Renin Activity Ratio in Hypertensive Patients with Increases of 11-Deoxycorticosterone and 18-Hydroxy-ll-Deoxycorticosterone: A Subtype of Essential Hypertension?

Author

Nobuyuki Takasu, Ichiro Komiya, Akimi Ogawa, Yuzo Maruyama, Toru Aizawa, Takashi Yamada, and Akihiro Niwa

Subjects
endocrine system, medicine.medical_specialty, Aldosterone, endocrine system diseases, business.industry, urologic and male genital diseases, medicine.disease, Essential hypertension, Plasma renin activity, female genital diseases and pregnancy complications, Pheochromocytoma, chemistry.chemical_compound, Endocrinology, chemistry, Corticosterone, Internal medicine, Renin–angiotensin system, medicine, Pharmacology (medical), Cardiology and Cardiovascular Medicine, business, 11-Deoxycorticosterone, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, medicine.drug
Abstract

Among 436 patients with hypertension unrelated to any renal lesion, renovascular damage, pheochromocytoma, Cushing’s syndrome or hyperthyroidism, 15 patients had low plasma renin activity (PRA) and el

Published
1991
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4. Regression of Left Ventricular Hypertrophy in Patients with Essential Hypertension: Outcome of 12 Years Antihypertensive Treatment

Author

Motoyoshi Tsujino, Nobuyuki Takasu, Satoshi Shigematsu, Toru Aizawa, Zenji Shimizu, Takashi Yamada, Akihiro Niwa, Yasuhiro Miyahara, and Kunihide Hiramatsu

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Sodium Chloride Symporter Inhibitors, Adrenergic beta-Antagonists, Cardiomegaly, Benzothiadiazines, Left ventricular hypertrophy, Essential hypertension, Muscle hypertrophy, Electrocardiography, Nifedipine, Internal medicine, medicine, Humans, Pharmacology (medical), Methyldopa, Myocardial infarction, Diuretics, Antihypertensive Agents, Thiazide, Aged, business.industry, Middle Aged, medicine.disease, Blood pressure, Echocardiography, Hypertension, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, medicine.drug
Abstract

To assess the regression of cardiac hypertrophy during long-term (12 years) antihypertensive treatment, the following parameters were determined in 93 patients with essential hypertension: SV1 + RV5 by electrocardiography (ECG), and septal wall (SW) and posterior wall (PW) thickness by echocardiography (UCG). The patients were treated with a thiazide diuretic alone (group 1), thiazide + beta-blocker (group 2), thiazide + methyldopa or nifedipine (group 3) or nifedipine or methyldopa alone (group 4). The blood pressure decreased gradually within 6 months of treatment. According to ECG, regression of left ventricular hypertrophy occurred during the initial 7 years in all groups, whereas in the subsequent 5 years, statistically significant regression was found only in the patients treated with thiazide + other drugs (group 3). By UCG, which was taken only at the 7th and 12th year, regression was detectable during the last 5 years in all groups. The apparent incidence of regression of hypertrophy was lower in the thiazide-alone group (group 1) than in the thiazide + beta-blocker group (group 2), most likely due to mild hypertension in group 1. A cardiovascular accident (nonfatal myocardial infarction) occurred only in 1 patient. We conclude that during long-term antihypertensive treatment, persistent, progressive reversal of cardiac hypertrophy takes place.

Published
1990
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5. Subject Index, Vol. 80, 1992

Author

Ruben Storino, Joseph Shemesh, Yochai Birnbaum, M. Schena, José Milei, Mitsuo Inada, Amos Pines, Ildefonso Echánove, M. Schumacher, S. Nakamura, Aviv Mager, Richard S. Meltzer, Aurelio Quesada, Daniel Ayalon, John Po-Shan Li, Victor J. Ferrans, Jens Berning, Graciela Fernandez Alonso, Michael Motro, Knut Borch-Johnsen, Wulin Aerbajinai, Samuel Sclarovsky, B. Eber, Silvia Vanzulli, O. Luha, Pia Eiken, Akihiro Niwa, Bo Gullberg, A. Owen, S. Scalvini, Loris Montanari, Monica Bocciolone, K. Taniguchi, Rafael Payá, Bruno Bagni, Maria Cruz Torregrosa, Cesare Cuspidi, Mark N. Allen, Yaacov Drory, Guillermo Soriano, Per Fruergaard, William MacNee, Fujiki Ishihara, Annie Barratt, Ricardo Beigelman, P. Zardini, Enrique Z. Fisman, Francesco Portaluppi, Eldad Rechavia, Satoshi Ogawa, P. Marino, Tetsuro Sugiura, Anna Rosa Cavallini, Yutaka Kimura, S. Marangoni, Renato Bragato, A. Koike, Bengt W. Johansson, Yoram Levo, Jan J. Kellermann, Yau-Ting Tai, Merete Appleyard, Alberto Zanchetti, Shunnosuke Honda, Laura Lonati, G.F. Levi, Ole Hansen, Boris Strasberg, Toshiji Iwasaka, David Harpaz, A. Quadri, Arnon Blum, Ettore C. degli Uberti, Gastone Leonetti, Paolo Gilli, H. Itoh, Ping-Ching Fong, K M Skwarski, Yasuo Takayama, Francisco Ridocci, H. Toplak, Luciana Vergnani, Kathy Lai-Fun Lee, T. Tsujibayashi, L. Rossi, Toru Aizawa, Per Eliasen, A. Tiran, M. Volterrani, Giovanni Tarroni, W. Klein, Y. Sato, José A. De Velasco, Shinya Goto, E. Carbonieri, Noritaka Tarumi, Chu-Pak Lau, Nobuyuki Takasu, L. Zanolla, Satoshi Shigematsu, Gian Paolo Bezante, R. Gasser, Seishi Nakamura, Takashi Yamada, Koichi Matsuo, Lea Boselli, S. Trotter, Hisato Nakamori, Lorena Sampieri, Jeppe Launbjerg, and Kunihide Hiramatsu

Subjects
Index (economics), business.industry, Statistics, Medicine, Pharmacology (medical), Subject (documents), Cardiology and Cardiovascular Medicine, business
Published
1992
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6. Echocardiographic Studies on the Relationship between Atrial Fibrillation and Atrial Enlargement in Patients with Hyperthyroidism of Graves’ Disease

Author

Kunihide Hiramatsu, Masaki Ishihara, Tsutomu Iwasaki, Manabu Murakami, Takashi Yamada, Toru Aizawa, Yasuhiro Miyahara, Akihiro Niwa, and Motoji Naka

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Atrial enlargement, Graves' disease, Cardiomegaly, Disease, Left atrial, Internal medicine, Atrial Fibrillation, medicine, Humans, Pharmacology (medical), In patient, Heart Atria, cardiovascular diseases, Basedow Disease, Child, Aged, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, Graves Disease, Thyrotoxicosis, Echocardiography, Hypertension, cardiovascular system, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Complication, business
Abstract

In order to study the relationship between the left atrial size and atrial fibrillation (AF) in patients with thyrotoxicosis, 92 patients with Graves' disease were examined. Out of 92 patients (23 men and 69 women, age 7-71 years), 21% had AF: 31% of the patients older than 40 years had AF whereas none of the patients younger than 40 years had AF. Echocardiography revealed that the left atrial enlargement (more than 40 mm) exist in 7% of patients younger than 40 years, in 2% of those older than 40 years without AF and 94% of those older than 40 years with AF. Serum T3 and T4 were higher in the patients with AF than in those without AF when patients older than 40 years were analyzed.

Published
1989
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