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2 results on '"Zhiao Chen"'

1. Carbonic anhydrase 2 inhibits epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma

Author

Chenyue Zhang, Haiyong Wang, Litao Xu, Zhiqiang Meng, Zhenfeng Zhu, Zhouyu Ning, Liping Zhuang, Zhiao Chen, and Peng Wang

Subjects
0301 basic medicine, Male, Cancer Research, Carcinoma, Hepatocellular, Epithelial-Mesenchymal Transition, Mice, Nude, Kaplan-Meier Estimate, Carbonic Anhydrase II, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Cell Movement, Carbonic anhydrase, medicine, Carcinoma, Biomarkers, Tumor, Animals, Humans, Genes, Tumor Suppressor, Neoplasm Invasiveness, Epithelial–mesenchymal transition, neoplasms, Aged, Mice, Inbred BALB C, biology, Chemistry, Liver Neoplasms, Cancer, Cell migration, General Medicine, Middle Aged, medicine.disease, digestive system diseases, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, biology.protein, Cancer research, Heterografts, Female, Sodium-Potassium-Exchanging ATPase
Abstract

Carbonic anhydrase 2 (CA2) plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes; however, its role in cancer remains obscure. In this study, we identified a novel function of CA2 in facilitating hepatocellular carcinoma (HCC) metastasis. CA2 expression was elevated in Na+-K+-ATPase α1 (ATP1A1)-downregulated HCC cells and was inversely correlated with that of ATP1A1 in HCC. ATP1A1 acted as an oncoprotein whereas CA2 overexpression inhibited cell migration and invasion by reversing epithelial-mesenchymal transition (EMT) in HCC. CA2 downregulation promoted HCC metastasis and invasion whereas ATP1A1 downregulation inhibited HCC metastasis. Because of the opposing effects of CA2 and ATP1A1 in HCC, we examined the role of their correlation in HCC metastasis. CA2 attenuated ATP1A1-triggered tumor growth in vivo and ATP1A1-induced metastasis in vitro. Taken together, the present results suggest that CA2 serves as a suppressor of HCC metastasis and EMT and is correlated with favorable overall survival (OS) in HCC patients.

Published
2017

2. Carbonic anhydrase 2 inhibits epithelial-mesenchymal transition and metastasis in hepatocellular carcinoma.

Author

Chenyue Zhang, Haiyong Wang, Zhiao Chen, Liping Zhuang, Litao Xu, Zhouyu Ning, Zhenfeng Zhu, Peng Wang, and Zhiqiang Meng

Subjects
CARBONIC anhydrase inhibitors, METASTASIS, LIVER cancer prevention, ADENOSINE triphosphatase, PROTEIN expression, PREVENTION
Abstract

Carbonic anhydrase 2 (CA2) plays vital role in the regulation of ion transport and pH balance and is involved in many biological processes; however, its role in cancer remains obscure. In this study, we identified a novel function of CA2 in facilitating hepatocellular carcinoma (HCC) metastasis. CA2 expression was elevated in Na+-K+-ATPase a1 (ATP1A1)- downregulated HCC cells and was inversely correlated with that of ATP1A1 in HCC. ATP1A1 acted as an oncoprotein whereas CA2 overexpression inhibited cell migration and invasion by reversing epithelial-mesenchymal transition (EMT) in HCC. CA2 downregulation promoted HCC metastasis and invasion whereas ATP1A1 downregulation inhibited HCC metastasis. Because of the opposing effects of CA2 and ATP1A1 in HCC, we examined the role of their correlation in HCC metastasis. CA2 attenuated ATP1A1-triggered tumor growth in vivo and ATP1A1-induced metastasis in vitro. Taken together, the present results suggest that CA2 serves as a suppressor of HCC metastasis and EMT and is correlated with favorable overall survival (OS) in HCC patients. [ABSTRACT FROM AUTHOR]

Published
2018
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