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Start Over Author "Yao Song" Journal carcinogenesis
8 results on '"Yao Song"'

1. Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial

Author

Tang, Li, Platek, Mary E, Yao, Song, Till, Cathee, Goodman, Phyllis J, Tangen, Catherine M, Wu, Yue, Platz, Elizabeth A, Neuhouser, Marian L, Stanczyk, Frank Z, Reichardt, Juergen K V, Santella, Regina M, Hsing, Ann, Figg, William D, Lippman, Scott M, Thompson, Ian M, and Ambrosone, Christine B

Published
2018
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4. Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: results from the Prostate Cancer Prevention Trial

Author

Tang, Li, primary, Platek, Mary E, additional, Yao, Song, additional, Till, Cathee, additional, Goodman, Phyllis J, additional, Tangen, Catherine M, additional, Wu, Yue, additional, Platz, Elizabeth A, additional, Neuhouser, Marian L, additional, Stanczyk, Frank Z, additional, Reichardt, Juergen K V, additional, Santella, Regina M, additional, Hsing, Ann, additional, Figg, William D, additional, Lippman, Scott M, additional, Thompson, Ian M, additional, and Ambrosone, Christine B, additional

Published
2017
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5. Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium

Author

Zhang, Jianmin, primary, Yao, Song, additional, Hu, Qiang, additional, Zhu, Qianqian, additional, Liu, Song, additional, Lunetta, Kathryn L., additional, Haddad, Stephen A., additional, Yang, Nuo, additional, Shen, He, additional, Hong, Chi-Chen, additional, Sucheston-Campbell, Lara, additional, Ruiz-Narvaez, Edward A., additional, Bensen, Jeannette T., additional, Troester, Melissa A., additional, Bandera, Elisa V., additional, Rosenberg, Lynn, additional, Haiman, Christopher A., additional, Olshan, Andrew F., additional, Palmer, Julie R., additional, and Ambrosone, Christine B., additional

Published
2016
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6. An exome-wide analysis of low frequency and rare variants in relation to risk of breast cancer in African American Women: the AMBER Consortium

Author

Haddad, Stephen A., primary, Ruiz-Narváez, Edward A., additional, Haiman, Christopher A., additional, Sucheston-Campbell, Lara E., additional, Bensen, Jeannette T., additional, Zhu, Qianqian, additional, Liu, Song, additional, Yao, Song, additional, Bandera, Elisa V., additional, Rosenberg, Lynn, additional, Olshan, Andrew F., additional, Ambrosone, Christine B., additional, Palmer, Julie R., additional, and Lunetta, Kathryn L., additional

Published
2016
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7. Genetic variants in the mTOR pathway and breast cancer risk in African American women

Author

Cheng, Ting-Yuan David, primary, Ambrosone, Christine B., additional, Hong, Chi-Chen, additional, Lunetta, Kathryn L., additional, Liu, Song, additional, Hu, Qiang, additional, Yao, Song, additional, Sucheston-Campbell, Lara, additional, Bandera, Elisa V., additional, Ruiz-Narváez, Edward A., additional, Haddad, Stephen, additional, Troester, Melissa A., additional, Haiman, Christopher A., additional, Bensen, Jeannette T., additional, Olshan, Andrew F., additional, Palmer, Julie R., additional, and Rosenberg, Lynn, additional

Published
2015
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8. Genetic variants in the mTOR pathway and breast cancer risk in African American women.

Author

Cheng TD, Ambrosone CB, Hong CC, Lunetta KL, Liu S, Hu Q, Yao S, Sucheston-Campbell L, Bandera EV, Ruiz-Narváez EA, Haddad S, Troester MA, Haiman CA, Bensen JT, Olshan AF, Palmer JR, and Rosenberg L

Subjects
Adult, Aged, Breast Neoplasms metabolism, Carcinoma in Situ ethnology, Carcinoma in Situ genetics, Carcinoma in Situ metabolism, Carcinoma, Ductal, Breast ethnology, Carcinoma, Ductal, Breast genetics, Carcinoma, Ductal, Breast metabolism, Case-Control Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Middle Aged, Neoplasm Invasiveness, Polymorphism, Single Nucleotide, Receptors, Estrogen metabolism, Signal Transduction genetics, TOR Serine-Threonine Kinases metabolism, Young Adult, Black or African American genetics, Breast Neoplasms ethnology, Breast Neoplasms genetics, TOR Serine-Threonine Kinases genetics
Abstract

The phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (mTOR) pathway has been implicated in breast carcinogenesis. However, there has been no large-scale investigation of genetic variants in the mTOR pathway and breast cancer risk. We examined 28847 single-nucleotide polymorphisms (SNPs) in 61 mTOR pathway genes in the African American Breast Cancer Epidemiology and Risk consortium of 3663 cases [1983 estrogen receptor-positive (ER+) and 1098 ER-negative (ER-)] and 4687 controls. Gene-level analyses were conducted using the adaptive rank truncated product (ARTP) test for 10773 SNPs that were not highly correlated (r (2) < 0.8), and SNP-level analyses were conducted with logistic regression. Among genes that were prioritized (nominal P < 0.05, ARTP tests), associations were observed for intronic SNPs TSC2 rs181088346 [odds ratio (OR) of each copy of variant allele = 0.77, 95% confidence interval (CI) = 0.65-0.88 for all breast cancer] and BRAF rs114729114 (OR = 1.53, 95% CI = 1.24-1.91 for all breast cancer and OR = 2.03, 95% CI = 1.50-2.76 for ER- tumors). For ER- tumors, intronic SNPs PGF rs11542848 (OR = 1.38, 95% CI = 1.15-1.66) and rs61759375 (OR = 1.34, 95% CI = 1.14-1.57) and MAPK3 rs78564187 (OR = 1.26, 95% CI = 1.11-1.43) were associated with increased risk. These SNPs were significant at a gene-wide level (Bonferroni-corrected P < 0.05). The variant allele of RPS6KB2 rs35363135, a synonymous coding SNP, was more likely to be observed in ER- than ER+ tumors (OR = 1.18, 95% CI = 1.05-1.31, gene-wide Bonferroni-corrected P = 0.06). In conclusion, specific mTOR pathway genes are potentially important to breast cancer risk and to the ER negativity in African American women., (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2016
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