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Your search keyword '"Taioli, Emanuela"' showing total 27 results
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27 results on '"Taioli, Emanuela"'

2. Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey.

Author

Untalan, Matthew, Ivic-Pavlicic, Tara, and Taioli, Emanuela

Subjects
HEALTH & Nutrition Examination Survey, GLYPHOSATE, TANDEM mass spectrometry
Abstract

Objectives Glyphosate is the most commonly used herbicide in the USA; however, its safety is still under debate. We assessed glyphosate levels and their association with overall mortality in a representative sample of the US adult population from the 2013 to 2016 National Health and Nutrition Examination Survey. Methods We extracted data on urinary glyphosate (N  = 2910) measured by ion chromatography isotope-dilution tandem mass spectrometry. Associations between glyphosate concentrations and demographic, lifestyle and other exposures were analyzed. Data were linked to public-use Mortality Files for 2019. Results The mean (STD) glyphosate level was 0.53 (0.59) ng/ml, with 25.7% of the subjects having glyphosate levels at or below the detection limit. At multivariate analysis, age and creatinine were associated with glyphosate urinary levels (both P  < 0.0001). There was a borderline association between glyphosate levels and mortality (HRadj 1.33; 95% CI 0.99–1.77 P  = 0.06). When 3,5,6-trichloropyridinol was excluded from the Cox model, glyphosate exhibits a significant association with mortality (HRadj 1.33; 95% CI 1.00–1.77; P  = 0.0532). Conclusions These nationally representative data suggest that recent exposure to glyphosate could be associated with increased mortality. More studies are necessary to understand population-level risk associated with the product, given its widespread use in agriculture. [ABSTRACT FROM AUTHOR]

Published
2024
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4. TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders.

Author

Gerwen, Maaike van, Cerutti, Janete Maria, Mendes, Thais Biude, Brody, Rachel, Genden, Eric, Riggins, Gregory J, and Taioli, Emanuela

Subjects
THYROID cancer, BRAF genes, DISASTERS, ENTEROENDOCRINE cells, DISEASE risk factors
Abstract

The 2-fold excess thyroid cancer risk reported in multiple World Trade Center (WTC) disaster exposed cohorts cannot entirely be explained by surveillance and physician bias thus highlighting the need to investigate the potential consequences of the dust exposure, containing carcinogenic and endocrine disruptive elements, on the thyroid. This study investigated the presence of TERT promoter and BRAF V600E mutations in 20 WTC-exposed versus 23 matched non-exposed thyroid cancers as potential mechanism explaining the excess risk. Although no significant difference in BRAF V600E mutation was found, TERT promoter mutations were significantly more prevalent in WTC thyroid cancer versus non-exposed thyroid cancers (P = 0.021). The odds of a TERT promoter mutation was significantly higher in the WTC versus the non-WTC thyroid cancers after adjustment [ORadj: 7.11 (95% CI: 1.21–41.83)]. These results may indicate that exposure to the mixture of pollutants present in the WTC dust resulted in an excess thyroid cancer risk and potentially more aggressive thyroid cancer, warranting investigating WTC responders on thyroid-associated symptoms during their health checkups. Future studies should include long-term follow-up to provide important insights in whether thyroid-specific survival is negatively affected by WTC dust exposure and whether this is because of the presence of one or more driver mutations. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients

Author

Ragin, Camille, Liu, Jeffrey C., Jones, Gieira, Shoyele, Olubunmi, Sowunmi, Bukola, Kennett, Rachel, Gibbs, Denise, Blackman, Elizabeth, Esan, Michael, Brandwein, Margaret S., Devarajan, Karthik, Bussu, Francesco, Chernock, Rebecca, Chien, Chih-Yen, Cohen, Marc A., El-Mofty, Samir, Suzuki, Mikio, D’Souza, Gypsyamber, Funchain, Pauline, Eng, Charis, Gollin, Susanne M., Hong, Angela, Jung, Yuh-S, Krüger, Maximilian, Lewis, James, Jr, Morbini, Patrizia, Landolfo, Santo, Rittà, Massimo, Straetmans, Jos, Szarka, Krisztina, Tachezy, Ruth, Worden, Francis P., Nelson, Deborah, Gathere, Samuel, and Taioli, Emanuela

Published
2017
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6. Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases

Author

Yu, Haocheng, primary, Tuminello, Stephanie, additional, Alpert, Naomi, additional, van Gerwen, Maaike, additional, Yoo, Seungyeul, additional, Mulholland, David J, additional, Aaronson, Stuart A, additional, Donovan, Michael, additional, Oh, William K, additional, Gong, Yixuan, additional, Wang, Li, additional, Zhu, Jun, additional, and Taioli, Emanuela, additional

Published
2022
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8. HPV-associated lung cancers: an international pooled analysis

Author

Ragin, Camille, Obikoya-Malomo, Monisola, Kim, Sungjin, Chen, Zhengjia, Flores-Obando, Rafael, Gibbs, Denise, Koriyama, Chihaya, Aguayo, Francisco, Koshiol, Jill, Caporaso, Neil E., Carpagnano, Giovanna E., Ciotti, Marco, Dosaka-Akita, Hirotoshi, Fukayama, Masashi, Goto, Akiteru, Spandidos, Demetrios A., Gorgoulis, Vassilis, Heideman, Daniëlle A.M., van Boerdonk, Robert A.A., Hiroshima, Kenzo, Iwakawa, Reika, Kastrinakis, Nikolaos G., Kinoshita, Ichiro, Akiba, Suminori, Landi, Maria T., Liu, Eugene H., Wang, Jinn-Li, Mehra, Ranee, Khuri, Fadlo R., Lim, Wan-Teck, Owonikoko, Taofeek K., Ramalingam, Suresh, Sarchianaki, Emmanuela, Syrjanen, Kari, Tsao, Ming-Sound, Sykes, Jenna, Hee, Siew Wan, Yokota, Jun, Zaravinos, Apostolos, and Taioli, Emanuela

Published
2014
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9. Multi-institutional prostate cancer study of genetic susceptibility in populations of African descent

Author

Taioli, Emanuela, Flores-Obando, Rafael E., Agalliu, Ilir, Blanchet, Pascal, Bunker, Clareann H., Ferrell, Robert E., Jackson, Maria, Kidd, La Creis R., Kolb, Suzanne, Lavender, Nicol A., McFarlane-Anderson, Norma, Morrison, Seian S., Multigner, Luc, Ostrande, Elaine A., Park, Jong Y., Patrick, Alan L., Rebbeck, Timothy R., Romana, Marc, Stanford, Janet L., Ukoli, Flora, VanCleave, Tiva T., Zeigler-Johnson, Charnita M., Mutetwa, Batsirai, and Ragin, Camille

Published
2011
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18. Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk

Author

Benhamou, Simone, Lee, Won Jin, Alexandrie, Anna-Karin, Boffetta, Paolo, Bouchardy, Christine, Butkiewicz, Dorota, Brockmöller, Jurgen, Clapper, Margie L., Daly, Ann, Dolzan, Vita, Ford, Jean, Gaspari, Laura, Haugen, Aage, Hirvonen, Ari, Husgafvel-Pursiainen, Kirsti, Ingelman-Sundberg, Magnus, Kalina, Ivan, Kihara, Masahiro, Kremers, Pierre, Le Marchand, Loïc, London, Stephanie J., Nazar-Stewart, Valle, Onon-Kihara, Masako, Rannug, Agneta, Romkes, Marjorie, Ryberg, David, Seidegard, Janeric, Shields, Peter, Strange, Richard C., Stücker, Isabelle, To-Figueras, Jordi, Brennan, Paul, and Taioli, Emanuela

Published
2002

22. Prevalence of HPV infection in racial–ethnic subgroups of head and neck cancer patients

Author

Ragin, Camille, primary, Liu, Jeffrey C., primary, Jones, Gieira, primary, Shoyele, Olubunmi, primary, Sowunmi, Bukola, primary, Kennett, Rachel, primary, Gibbs, Denise, primary, Blackman, Elizabeth, primary, Esan, Michael, primary, Brandwein, Margaret S., primary, Devarajan, Karthik, primary, Bussu, Francesco, primary, Chernock, Rebecca, primary, Chien, Chih-Yen, primary, Cohen, Marc A., primary, El-Mofty, Samir, primary, Suzuki, Mikio, primary, D’Souza, Gypsyamber, primary, Funchain, Pauline, primary, Eng, Charis, primary, Gollin, Susanne M., primary, Hong, Angela, primary, Jung, Yuh-S, primary, Krüger, Maximilian, primary, Lewis, James, primary, Morbini, Patrizia, primary, Landolfo, Santo, primary, Rittà, Massimo, primary, Straetmans, Jos, primary, Szarka, Krisztina, primary, Tachezy, Ruth, primary, Worden, Francis P., primary, Nelson, Deborah, primary, Gathere, Samuel, primary, and Taioli, Emanuela, primary

Published
2016
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27. Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans

Author

Ford, Jean G., Li, Yongliang, O'Sullivan, Mary Margaret, Demopoulos, Rita, Garte, Seymour, Taioli, Emanuela, and Brandt-Rauf, Paul W.

Abstract

Glutathione S-transferase M1 (GSTM1) can detoxify many carcinogens, including polycyclic aromatic hydrocarbons such as those from cigarette smoke. Though a number of studies have been published about the association between GSTM1 polymorphism and lung cancer, this association has received limited attention in the African-American population. We conducted a case–control study to investigate the role of GSTM1 polymorphism in the development of lung cancer in African-Americans. Specimens of DNA from 117 lung cancer cases and 120 controls were assayed for detection of GSTM1 genotype by polymerase chain reaction (PCR). The odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with homozygous deletion of the GSTM1 gene and other risk factors were estimated by logistic regression. Thirty-seven of the 117 cases (31.6%) and 24 of the 120 controls (20.0%) had the GSTM1 null genotype; the OR was 2.10 (95% CI 1.07–4.11) after adjustment for age, gender and smoking. The association was higher for squamous cell carcinoma (OR 2.98, 95% CI 1.09–8.19) than for adenocarcinoma (OR 1.95, 95% CI 0.81–4.66). We observed a stronger association between GSTM1 null genotype and lung cancer among heavy smokers with ≥30 pack-years (OR 4.35, 95% CI 1.16–16.23). This association was also found in squamous cell carcinoma (OR 6.26, 95% CI 1.31–29.91). In the analysis combining GSTM1 polymorphism and smoking, smokers with the null genotype had high risk (OR 8.19, 95% CI 2.35–28.62) compared with non-smokers with the wild-type genotype, and the risk increased with smoking cigarette pack-years (P = 0.0001 for trend). Our results suggest that GSTM1 polymorphism plays a role in the development of lung cancer and modifies the risk for smoking-related lung cancer in African-Americans.

Published
2000

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