1. Synthesis and evaluation of N-alkyl-β-d-glucosylamines on the growth of two wood fungi, Coriolus versicolor and Poria placenta
- Author
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Stéphane Grelier, Véronique Coma, Théoneste Muhizi, LABORATOIRE DE RHEOLOGIE DU BOIS DE BORDEAUX (LRBB), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1
- Subjects
Antifungal ,Fungal growth ,Antifungal Agents ,Time Factors ,Coriolus versicolor ,medicine.drug_class ,Stereochemistry ,ANTIFUNGAL ACTIVITY ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Alkyl amine ,Analytical Chemistry ,Placenta ,medicine ,ACTIVITÉ ANTIFONGIQUE ,Amines ,Alkyl ,chemistry.chemical_classification ,Glucosamine ,010405 organic chemistry ,Chemistry ,CORIOLUS VERSICOLOR ,PORIA PLACENTA ,Organic Chemistry ,GLUCOSYLAMINES ,General Medicine ,0104 chemical sciences ,Chain length ,[CHIM.POLY]Chemical Sciences/Polymers ,medicine.anatomical_structure ,Polyporales - Abstract
Various glucosylamines were synthesized from glucose and different alkyl amine compounds. These amino compounds are β- d -glucopyranosylamine (GPA), N -ethyl-β- d -glucopyranosylamine (EtGPA), N -butyl-β- d -glucopyranosylamine (BuGPA), N -hexyl-β- d -glucopyranosylamine (HeGPA), N -octyl-β- d -glucopyranosylamine (OcGPA), N -dodecyl-β- d -glucopyranosylamine (DoGPA), N -(2-hydroxyethyl)-β- d -glucopyranosylamine (HEtGPA) and N , N -di(2-hydroxyethyl)-β- d -glucopyranosylamine (DHEtGPA). They were tested for their antifungal activity against the growth of Coriolus versicolor and Poria placenta . An improvement of the antifungal activity with the increase of alkyl chain length was observed. DoGPA exhibited the best antifungal activity against both strains. It completely inhibited the fungal growth at 0.01 × 10 −3 mol mL −1 and 0.0075 × 10 −3 mol mL −1 for C. versicolor and P. placenta , respectively. For other glucosylamines higher concentrations were needed for complete inhibition of fungi.
- Published
- 2008
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