1. Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis.
- Author
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Eid RK, Ashour DS, Essa EA, El Maghraby GM, and Arafa MF
- Subjects
- Administration, Oral, Albendazole administration & dosage, Albendazole chemistry, Animals, Antiprotozoal Agents administration & dosage, Antiprotozoal Agents chemistry, Chitosan administration & dosage, Drug Carriers administration & dosage, Drug Carriers chemistry, Lipids administration & dosage, Nanostructures administration & dosage, Parasitic Sensitivity Tests, Particle Size, Surface Properties, Albendazole pharmacology, Antiprotozoal Agents pharmacology, Chitosan chemistry, Lipids chemistry, Nanostructures chemistry, Trichinella spiralis drug effects
- Abstract
The study investigated chitosan coated nanostructured lipid carriers (NLCs) for oral delivery of albendazole in treatment of trichinellosis. NLCs comprised precirol and oleic acid with Tween and Span 80. Dicetylphosphate was used as charging agent to allow chitosan coating. Trichinella spiralis infected mice were used and albendazole suspension, coated or uncoated NLCs were orally administered at different stages of infection. NLCs were spherical with size of 188 and 200 nm for coated and uncoated NLC, respectively. Treatment during intestinal phase reduced worm count with NLCs showing better rank. This was reflected further by reduced larvae count and improved histopathological features. Starting treatment in the migrating phase reduced larval count by 62.9, 99.6 and 89.5 % after administration of suspension, coated and uncoated NLCs, respectively. The same rank was recorded for the encysted phase. NLCs enhanced the efficacy of albendazole against Trichinella spiralis compared with suspension with chitosan coated NLCs being superior., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
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