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12 results on '"Timmermann, Beate"'

1. Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation

Author

Adolph, Jonas E., primary, Fleischhack, Gudrun, additional, Tschirner, Sebastian, additional, Rink, Lydia, additional, Dittes, Christine, additional, Mikasch, Ruth, additional, Dammann, Philipp, additional, Mynarek, Martin, additional, Obrecht-Sturm, Denise, additional, Rutkowski, Stefan, additional, Bison, Brigitte, additional, Warmuth-Metz, Monika, additional, Pietsch, Torsten, additional, Pfister, Stefan M., additional, Pajtler, Kristian W., additional, Milde, Till, additional, Kortmann, Rolf-Dieter, additional, Dietzsch, Stefan, additional, Timmermann, Beate, additional, and Tippelt, Stephan, additional

Published
2024
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2. Impact of Modern Low Dose Involved Site Radiation Therapy on Normal Tissue Toxicity in Cervicothoracic Non-Hodgkin Lymphomas: A Biophysical Study

Author

Roers, Julian, primary, Rolf, Daniel, additional, Baehr, Andrea, additional, Pöttgen, Christoph, additional, Stickan-Verfürth, Martina, additional, Siats, Jan, additional, Hering, Dominik A., additional, Moustakis, Christos, additional, Grohmann, Maximilian, additional, Oertel, Michael, additional, Haverkamp, Uwe, additional, Stuschke, Martin, additional, Timmermann, Beate, additional, Eich, Hans T., additional, and Reinartz, Gabriele, additional

Published
2023
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3. Developments in the Surgical Approach to Staging and Resection of Rhabdomyosarcoma

Author

Terwisscha van Scheltinga, Sheila, primary, Rogers, Timothy, additional, Smeulders, Naima, additional, deCorti, Federica, additional, Guerin, Florent, additional, Craigie, Ross, additional, Burrieza, Gabriela Guillén, additional, Smeele, Ludi, additional, Hol, Marinka, additional, van Rijn, Rick, additional, Fuchs, Joerg, additional, Seitz, Guido, additional, Schmidt, Andreas, additional, Timmermann, Beate, additional, Tunn, Per-Ulf, additional, Chargari, Cyrus, additional, Dávila Fajardo, Raquel, additional, Slater, Olga, additional, Gains, Jenny, additional, and Merks, Hans, additional

Published
2023
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4. Proton Beam Therapy for Pediatric Tumors of the Central Nervous System—Experiences of Clinical Outcome and Feasibility from the KiProReg Study

Author

Peters, Sarah, primary, Frisch, Sabine, additional, Stock, Annika, additional, Merta, Julien, additional, Bäumer, Christian, additional, Blase, Christoph, additional, Schuermann, Eicke, additional, Tippelt, Stephan, additional, Bison, Brigitte, additional, Frühwald, Michael, additional, Rutkowski, Stefan, additional, Fleischhack, Gudrun, additional, and Timmermann, Beate, additional

Published
2022
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6. Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population

Author

Nemes, Karolina, primary, Johann, Pascal D., additional, Steinbügl, Mona, additional, Gruhle, Miriam, additional, Bens, Susanne, additional, Kachanov, Denis, additional, Teleshova, Margarita, additional, Hauser, Peter, additional, Simon, Thorsten, additional, Tippelt, Stephan, additional, Eberl, Wolfgang, additional, Chada, Martin, additional, Lopez, Vicente Santa-Maria, additional, Grigull, Lorenz, additional, Hernáiz-Driever, Pablo, additional, Eyrich, Matthias, additional, Pears, Jane, additional, Milde, Till, additional, Reinhard, Harald, additional, Leipold, Alfred, additional, van de Wetering, Marianne, additional, Gil-da-Costa, Maria João, additional, Ebetsberger-Dachs, Georg, additional, Kerl, Kornelius, additional, Lemmer, Andreas, additional, Boztug, Heidrun, additional, Furtwängler, Rhoikos, additional, Kordes, Uwe, additional, Vokuhl, Christian, additional, Hasselblatt, Martin, additional, Bison, Brigitte, additional, Kröncke, Thomas, additional, Melchior, Patrick, additional, Timmermann, Beate, additional, Gerss, Joachim, additional, Siebert, Reiner, additional, and Frühwald, Michael C., additional

Published
2022
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7. Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort

Author

Römer, Tristan, primary, Franzen, Sabrina, additional, Kravets, Hanna, additional, Farrag, Ahmed, additional, Makowska, Anna, additional, Christiansen, Hans, additional, Eble, Michael J., additional, Timmermann, Beate, additional, Staatz, Gundula, additional, Mottaghy, Felix M., additional, Bührlen, Martina, additional, Hagenah, Ulrich, additional, Puzik, Alexander, additional, Driever, Pablo Hernáiz, additional, Greiner, Jeanette, additional, Jorch, Norbert, additional, Tippelt, Stephan, additional, Schneider, Dominik T., additional, Kropshofer, Gabriele, additional, Overbeck, Tobias R., additional, Christiansen, Holger, additional, Brozou, Triantafyllia, additional, Escherich, Gabriele, additional, Becker, Martina, additional, Friesenbichler, Waltraud, additional, Feuchtinger, Tobias, additional, Puppe, Wolfram, additional, Heussen, Nicole, additional, Hilgers, Ralf D., additional, and Kontny, Udo, additional

Published
2022
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8. Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study

Author

Gaab, Christine, primary, Adolph, Jonas E., additional, Tippelt, Stephan, additional, Mikasch, Ruth, additional, Obrecht, Denise, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Pfister, Stefan M., additional, Milde, Till, additional, Witt, Olaf, additional, Bison, Brigitte, additional, Warmuth-Metz, Monika, additional, Kortmann, Rolf-Dieter, additional, Dietzsch, Stefan, additional, Pietsch, Torsten, additional, Timmermann, Beate, additional, Sträter, Ronald, additional, Bode, Udo, additional, Faldum, Andreas, additional, Kwiecien, Robert, additional, and Fleischhack, Gudrun, additional

Published
2022
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9. Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment

Author

Hill, Rebecca M., primary, Plasschaert, Sabine L. A., additional, Timmermann, Beate, additional, Dufour, Christelle, additional, Aquilina, Kristian, additional, Avula, Shivaram, additional, Donovan, Laura, additional, Lequin, Maarten, additional, Pietsch, Torsten, additional, Thomale, Ulrich, additional, Tippelt, Stephan, additional, Wesseling, Pieter, additional, Rutkowski, Stefan, additional, Clifford, Steven C., additional, Pfister, Stefan M., additional, Bailey, Simon, additional, and Fleischhack, Gudrun, additional

Published
2021
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10. Eye Tumors in Childhood as First Sign of Tumor Predisposition Syndromes: Insights from an Observational Study Conducted in Germany and Austria

Author

Reschke, Madlen, Biewald, Eva, Bronstein, Leo, Brecht, Ines B., Dittner-Moormann, Sabine, Driever, Frank, Ebinger, Martin, Fleischhack, Gudrun, Grabow, Desiree, Geismar, Dirk, Göricke, Sophia, Guberina, Maja, Le Guin, Claudia H. D., Kiefer, Tobias, Kratz, Christian P., Metz, Klaus, Müller, Bert, Ryl, Tatsiana, Schlamann, Marc, Schlüter, Sabrina, Schönberger, Stefan, Schulte, Johannes H., Sirin, Selma, Süsskind, Daniela, Timmermann, Beate, Ting, Saskia, Wackernagel, Werner, Wieland, Regina, Zenker, Martin, Zeschnigk, Michael, Reinhardt, Dirk, Eggert, Angelika, Ritter-Sovinz, Petra, Lohmann, Dietmar R., Bornfeld, Norbert, Bechrakis, Nikolaos, and Ketteler, Petra

Subjects
cancer predisposition syndrome, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Pathologie und Neuropathologie, genetic counseling, Medizinische Fakultät » Universitätsklinikum Essen » Zentrum für Kinder- und Jugendmedizin » Klinik für Pädiatrische Hämatologie, Onkologie und Endokrinologie, retinoblastoma -- uveal melanoma -- retinal astrocytoma -- ciliary body medulloepithelioma -- genetic counseling -- DICER1 syndrome -- nevus Ota -- cancer predisposition syndrome, genetic structures, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Augenheilkunde, Medizin, DICER1 syndrome, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, nevus Ota, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Strahlentherapie, lcsh:RC254-282, Article, retinoblastoma, eye diseases, Medizinische Fakultät » Universitätsklinikum Essen » Westdeutsches Protonentherapiezentrum (WPE), Medizinische Fakultät » Universitätsklinikum Essen » Institut für Humangenetik, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Diagnostische und Interventionelle Radiologie und Neuroradiologie, ciliary body medulloepithelioma, sense organs, ddc:610, uveal melanoma, retinal astrocytoma
Abstract

Simple Summary Eye tumors in children are very rare. In Europe, these eye tumors are nearly always diagnosed early and cure rates are high. However, eye tumors in childhood often occur as the first sign of a genetic tumor predisposition syndrome. This study collected data of children with malignant eye tumors diagnosed in five years in Germany and Austria to learn about the association of eye tumors in childhood with tumor predisposition syndrome. The study recruited 300 children with malignant eye tumors in childhood. In the here-presented cohort, more than 40% of eye tumors were associated with rare tumor predisposition syndromes. For this reason, all children with eye tumors and their families should receive genetic counseling for a tumor predisposition syndrome. Children with a genetic predisposition to cancer should receive a tailored surveillance, including detailed history, physical examination and, if indicated, imaging to screen for other cancers later in life. Abstract Retinoblastoma and other eye tumors in childhood are rare diseases. Many eye tumors are the first signs of a genetic tumor predisposition syndrome and the affected children carry a higher risk of developing other cancers later in life. Clinical and genetic data of all children with eye tumors diagnosed between 2013–2018 in Germany and Austria were collected in a multicenter prospective observational study. In five years, 300 children were recruited into the study: 287 with retinoblastoma, 7 uveal melanoma, 3 ciliary body medulloepithelioma, 2 retinal astrocytoma, 1 meningioma of the optic nerve extending into the eye. Heritable retinoblastoma was diagnosed in 44% of children with retinoblastoma. One child with meningioma of the optic nerve extending into the eye was diagnosed with neurofibromatosis 2. No pathogenic constitutional variant in DICER1 was detected in a child with medulloepithelioma while two children did not receive genetic analysis. Because of the known association with tumor predisposition syndromes, genetic counseling should be offered to all children with eye tumors. Children with a genetic predisposition to cancer should receive a tailored surveillance including detailed history, physical examinations and, if indicated, imaging to screen for other cancer. Early detection of cancers may reduce mortality.

Published
2021

11. Feasibility of Proton Beam Therapy as a Rescue Therapy in Heavily Pre-Treated Retinoblastoma Eyes

Author

Biewald, Eva, primary, Kiefer, Tobias, additional, Geismar, Dirk, additional, Schlüter, Sabrina, additional, Manthey, Anke, additional, Westekemper, Henrike, additional, Wulff, Jörg, additional, Timmermann, Beate, additional, Ketteler, Petra, additional, Schönberger, Stefan, additional, Metz, Klaus A., additional, Ting, Saskia, additional, Göricke, Sophia, additional, Bechrakis, Nikolaos E., additional, and Bornfeld, Norbert, additional

Published
2021
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12. Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment.

Author

Hill, Rebecca M., Plasschaert, Sabine L. A., Timmermann, Beate, Dufour, Christelle, Aquilina, Kristian, Avula, Shivaram, Donovan, Laura, Lequin, Maarten, Pietsch, Torsten, Thomale, Ulrich, Tippelt, Stephan, Wesseling, Pieter, Rutkowski, Stefan, Clifford, Steven C., Pfister, Stefan M., Bailey, Simon, and Fleischhack, Gudrun

Subjects
BIOPSY, IMMUNE checkpoint inhibitors, CANCER chemotherapy, GLIOMAS, DISEASE relapse, MOLECULAR biology, DOSE-response relationship (Radiation), DECISION making, RADIOTHERAPY, IMMUNOTHERAPY
Abstract

Simple Summary: Medulloblastoma is the commonest malignant brain tumour of childhood. Disease relapse following maximal multi-modal therapy including upfront craniospinal irradiation (CSI) is almost always fatal and occurs in approximately 30% of patients. Importantly, patients rarely die of other causes, and consequently relapsed medulloblastoma (rMB) accounts for 10% of all childhood cancer deaths. There is a variety of life-prolonging treatment options at relapse including neurosurgery, re-irradiation, early-phase trials, and chemotherapy. Here, we summarise best practice for investigations including re-biopsy and molecular characterisation of rMB, treatment decision making, and available treatment options. We also highlight advances in the understanding of rMB disease biology and prognostic factors, and look towards future developments such as targeted therapies, liquid biopsies and disease modelling strategies to improve outcomes in this area of unmet clinical need. Relapsed medulloblastoma (rMB) accounts for a considerable, and disproportionate amount of childhood cancer deaths. Recent advances have gone someway to characterising disease biology at relapse including second malignancies that often cannot be distinguished from relapse on imaging alone. Furthermore, there are now multiple international early-phase trials exploring drug–target matches across a range of high-risk/relapsed paediatric tumours. Despite these advances, treatment at relapse in pre-irradiated patients is typically non-curative and focuses on providing life-prolonging and symptom-modifying care that is tailored to the needs and wishes of the individual and their family. Here, we describe the current understanding of prognostic factors at disease relapse such as principal molecular group, adverse molecular biology, and timing of relapse. We provide an overview of the clinical diagnostic process including signs and symptoms, staging investigations, and molecular pathology, followed by a summary of treatment modalities and considerations. Finally, we summarise future directions to progress understanding of treatment resistance and the biological mechanisms underpinning early therapy-refractory and relapsed disease. These initiatives include development of comprehensive and collaborative molecular profiling approaches at relapse, liquid biopsies such as cerebrospinal fluid (CSF) as a biomarker of minimal residual disease (MRD), modelling strategies, and the use of primary tumour material for real-time drug screening approaches. [ABSTRACT FROM AUTHOR]

Published
2022
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