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18 results on '"Sethi, Gautam"'

3. Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma

Author

Yang, Min Hee, primary, Mohan, Chakrabhavi Dhananjaya, additional, Deivasigamani, Amudha, additional, Chinnathambi, Arunachalam, additional, Alharbi, Sulaiman Ali, additional, Rangappa, Kanchugarakoppal S., additional, Jung, Sang Hoon, additional, Ko, Hyejin, additional, Hui, Kam Man, additional, Sethi, Gautam, additional, and Ahn, Kwang Seok, additional

Published
2022
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4. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway

Author

Arora, Loukik, primary, Mohan, Chakrabhavi Dhananjaya, additional, Yang, Min Hee, additional, Rangappa, Shobith, additional, Deivasigamani, Amudha, additional, Kumar, Alan Prem, additional, Kunnumakkara, Ajaikumar B., additional, Garg, Manoj, additional, Chinnathambi, Arunachalam, additional, Alharbi, Sulaiman Ali, additional, Alahmadi, Tahani Awad, additional, Rangappa, Kanchugarakoppal S., additional, Hui, Kam Man, additional, Sethi, Gautam, additional, and Ahn, Kwang Seok, additional

Published
2021
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5. Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis

Author

Datta, Arpita, primary, Deng, Shuo, additional, Gopal, Vennila, additional, Yap, Kenneth Chun-Hong, additional, Halim, Clarissa Esmeralda, additional, Lye, Mun Leng, additional, Ong, Mei Shan, additional, Tan, Tuan Zea, additional, Sethi, Gautam, additional, Hooi, Shing Chuan, additional, Kumar, Alan Prem, additional, and Yap, Celestial T., additional

Published
2021
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8. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Author

Wang, Wei, primary, Shanmugam, Muthu K., additional, Xiang, Ping, additional, Yam, Ting Yu Amelia, additional, Kumar, Vineet, additional, Chew, Wee Siong, additional, Chang, Jing Kai, additional, Ali, Muhammad Zulfaqar Bin, additional, Reolo, Marie J. Y., additional, Peh, Yee Xin, additional, Abdul Karim, Siti Nasuha Binte, additional, Tan, Andrew Y.Y., additional, Sanda, Takaomi, additional, Sethi, Gautam, additional, and Herr, Deron R., additional

Published
2020
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11. FBXW7 in Cancer: What Has Been Unraveled Thus Far?

Author

Sailo, Bethsebie Lalduhsaki, primary, Banik, Kishore, additional, Girisa, Sosmitha, additional, Bordoloi, Devivasha, additional, Fan, Lu, additional, Halim, Clarissa Esmeralda, additional, Wang, Hong, additional, Kumar, Alan Prem, additional, Zheng, Dali, additional, Mao, Xinliang, additional, Sethi, Gautam, additional, and Kunnumakkara, Ajaikumar Bahulayan, additional

Published
2019
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17. NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration and Chemoresistance

Author

Monisha, Javadi, primary, Roy, Nand, additional, Padmavathi, Ganesan, additional, Banik, Kishore, additional, Bordoloi, Devivasha, additional, Khwairakpam, Amrita, additional, Arfuso, Frank, additional, Chinnathambi, Arunachalam, additional, Alahmadi, Tahani, additional, Alharbi, Sulaiman, additional, Sethi, Gautam, additional, Kumar, Alan, additional, and Kunnumakkara, Ajaikumar, additional

Published
2018
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18. Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma.

Author

Bhuvanalakshmi, Gurubharathi, Gamit, Naisarg, Patil, Manasi, Arfuso, Frank, Sethi, Gautam, Dharmarajan, Arun, Prem Kumar, Alan, and Warrier, Sudha

Subjects
REACTIVE oxygen species, APOPTOSIS, CALCIUM, CELL receptors, CELLULAR signal transduction, DNA, GENETIC techniques, GLIOMAS, ONCOGENES, STEM cells, WNT proteins, MICRORNA
Abstract

Background: Chemotherapeutic resistance of glioblastoma has been attributed to a self-renewing subpopulation, the glioma stem cells (GSCs), which is known to be maintained by the Wnt β−catenin pathway. Our previous findings demonstrated that exogeneous addition of the Wnt antagonist, secreted fizzled-related protein 4 (sFRP4) hampered stem cell properties in GSCs. Methods: To understand the molecular mechanism of sFRP4, we overexpressed sFRP4 (sFRP4 OE) in three human glioblastoma cell lines U87MG, U138MG, and U373MG. We also performed chromatin immunoprecipitation (ChIP) sequencing of sFRP4 OE and RNA sequencing of sFRP4 OE and sFRP4 knocked down U87 cells. Results: We observed nuclear localization of sFRP4, suggesting an unknown nuclear role. ChIP-sequencing of sFRP4 pulldown DNA revealed a homeobox Cphx1, related to the senescence regulator ETS proto-oncogene 2 (ETS2). Furthermore, miRNA885, a p53-mediated apoptosis inducer, was upregulated in sFRP4 OE cells. RNA sequencing analysis suggested that sFRP4-mediated apoptosis is via the Fas-p53 pathway by activating the Wnt calcium and reactive oxygen species pathways. Interestingly, sFRP4 OE cells had decreased stemness, but when knocked down in multipotent mesenchymal stem cells, pluripotentiality was induced and the Wnt β-catenin pathway was upregulated. Conclusions: This study unveils a novel nuclear role for sFRP4 to promote apoptosis by a possible activation of DNA damage machinery in glioblastoma. [ABSTRACT FROM AUTHOR]

Published
2019
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