1. Zebrafish in Lung Cancer Research.
- Author
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Wu, Xiaodi, Hua, Xin, Xu, Ke, Song, Yong, and Lv, Tangfeng
- Subjects
BIOLOGICAL models ,DISEASE progression ,IN vivo studies ,GENETICS ,ANIMAL experimentation ,LUNG tumors ,INDIVIDUALIZED medicine ,MOLECULAR biology ,FISHES ,DRUG development ,MEDICAL research - Abstract
Simple Summary: Zebrafish is a crucial in vivo model for lung cancer research and is widely employed in studies focusing on cancer proliferation, metastasis, and angiogenesis. It plays a pivotal role in cancer drug development, being used for target validation, compound screening, and personalized therapy. This review provides a comprehensive overview of the current state of lung cancer research that uses zebrafish, highlighting the advantages and limitations of this model organism and discussing future directions in the field. Zebrafish is increasingly used as a model organism for cancer research because of its genetic and physiological similarities to humans. Modeling lung cancer (LC) in zebrafish has received significant attention. This review focuses on the insights gained from using zebrafish in LC research. These insights range from investigating the genetic and molecular mechanisms that contribute to the development and progression of LC to identifying potential drug targets, testing the efficacy and toxicity of new therapies, and applying zebrafish for personalized medicine studies. This review provides a comprehensive overview of the current state of LC research performed using zebrafish, highlights the advantages and limitations of this model organism, and discusses future directions in the field. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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