Search

Your search keyword '"Kluźniak, Wojciech"' showing total 5 results
Start Over Author "Kluźniak, Wojciech" Journal cancers
5 results on '"Kluźniak, Wojciech"'

1. Risk of Second Primary Thyroid Cancer in Women with Breast Cancer

Author

Cieszyńska, Monika, primary, Kluźniak, Wojciech, additional, Wokołorczyk, Dominika, additional, Cybulski, Cezary, additional, Huzarski, Tomasz, additional, Gronwald, Jacek, additional, Falco, Michał, additional, Dębniak, Tadeusz, additional, Jakubowska, Anna, additional, Derkacz, Róża, additional, Marciniak, Wojciech, additional, Lener, Marcin, additional, Woronko, Karolina, additional, Mocarz, Dominika, additional, Baszuk, Piotr, additional, Bryśkiewicz, Marta, additional, Narod, Steven A., additional, and Lubiński, Jan, additional

Published
2022
Full Text
View/download PDF

2. Recurrent Mutations in BRCA1, BRCA2, RAD51C, PALB2 and CHEK2 in Polish Patients with Ovarian Cancer

Author

Łukomska, Alicja, primary, Menkiszak, Janusz, additional, Gronwald, Jacek, additional, Tomiczek-Szwiec, Joanna, additional, Szwiec, Marek, additional, Jasiówka, Marek, additional, Blecharz, Paweł, additional, Kluz, Tomasz, additional, Stawicka-Niełacna, Małgorzata, additional, Mądry, Radosław, additional, Białkowska, Katarzyna, additional, Prajzendanc, Karolina, additional, Kluźniak, Wojciech, additional, Cybulski, Cezary, additional, Dębniak, Tadeusz, additional, Huzarski, Tomasz, additional, Tołoczko-Grabarek, Aleksandra, additional, Byrski, Tomasz, additional, Baszuk, Piotr, additional, Narod, Steven A., additional, Lubiński, Jan, additional, and Jakubowska, Anna, additional

Published
2021
Full Text
View/download PDF

3. Prevalence of Recurrent Mutations Predisposing to Breast Cancer in Early-Onset Breast Cancer Patients from Poland

Author

Rogoża-Janiszewska, Emilia, primary, Malińska, Karolina, additional, Cybulski, Cezary, additional, Jakubowska, Anna, additional, Gronwald, Jacek, additional, Huzarski, Tomasz, additional, Lener, Marcin, additional, Górski, Bohdan, additional, Kluźniak, Wojciech, additional, Rudnicka, Helena, additional, Akbari, Mohammad, additional, Kashyap, Aniruddh, additional, Narod, Steven, additional, Lubiński, Jan, additional, Dębniak, Tadeusz, additional, and Polish Hereditary Breast Cancer Consortium, on behalf of the, additional

Published
2020
Full Text
View/download PDF

4. Inherited Variants in BLM and the Risk and Clinical Characteristics of Breast Cancer

Author

Kluźniak, Wojciech, primary, Wokołorczyk, Dominika, additional, Rusak, Bogna, additional, Huzarski, Tomasz, additional, Kashyap, Aniruddh, additional, Stempa, Klaudia, additional, Rudnicka, Helena, additional, Jakubowska, Anna, additional, Szwiec, Marek, additional, Morawska, Sylwia, additional, Gliniewicz, Katarzyna, additional, Mordak, Karina, additional, Stawicka, Małgorzata, additional, Jarkiewicz-Tretyn, Joanna, additional, Cechowska, Magdalena, additional, Domagała, Paweł, additional, Dębniak, Tadeusz, additional, Lener, Marcin, additional, Gronwald, Jacek, additional, Lubiński, Jan, additional, Narod, Steven A., additional, Akbari, Mohammad R., additional, and Cybulski, Cezary, additional

Published
2019
Full Text
View/download PDF

5. Do BARD1 Mutations Confer an Elevated Risk of Prostate Cancer?

Author

Stempa, Klaudia, Wokołorczyk, Dominika, Kluźniak, Wojciech, Rogoża-Janiszewska, Emilia, Malińska, Karolina, Rudnicka, Helena, Huzarski, Tomasz, Gronwald, Jacek, Gliniewicz, Katarzyna, Dębniak, Tadeusz, Jakubowska, Anna, Lener, Marcin, Tomiczek-Szwiec, Joanna, Domagała, Paweł, Suszynska, Malwina, Kozlowski, Piotr, Kluz, Tomasz, Naczk, Mariusz, Lubiński, Jan, and Narod, Steven A.

Subjects
GENETIC mutation, CONFIDENCE intervals, BRCA genes, MEDICAL screening, CANCER patients, DISEASE susceptibility, DESCRIPTIVE statistics, DISEASE prevalence, ODDS ratio, PROSTATE tumors, DISEASE risk factors
Abstract

Simple Summary: Current cancer testing gene panels tend to be comprehensive. One of the genes commonly included in the testing panels is BARD1. To establish whether BARD1 mutations predispose to prostate cancer, we sequenced BARD1 in 390 hereditary prostate cancer cases, genotyped 5715 men with unselected prostate cancer and 10,252 controls for three recurrent rare BARD1 variants in Poland. We did not see an elevated prostate risk cancer given p.Q564X truncating mutation, p.R658C missense mutation and p.R659= synonymous variant. Neither variant influenced prostate cancer characteristics or survival. Our study is the first to evaluate the association between BARD1 mutations and prostate cancer susceptibility. It is not justified to inform men about increased prostate cancer risk in case of identification of a BARD1 mutation. However, a female relative of a man with a BARD1 mutation may benefit from this information and be tested, because BARD1 is a breast cancer susceptibility gene. The current cancer testing gene panels tend to be comprehensive rather than site-specific. BARD1 is one of the genes commonly included in the multi-cancer testing panels. Mutations in BARD1 confer an increase in the risk for breast cancer, but it is not studied whether or not they predispose to prostate cancer. To establish if BARD1 mutations also predispose to prostate cancer, we screened BARD1 in 390 Polish patients with hereditary prostate cancer. No truncating mutations were identified by sequencing. We also genotyped 5715 men with unselected prostate cancer, and 10,252 controls for three recurrent BARD1 variants, including p.Q564X, p.R658C and p.R659=. Neither variant conferred elevated risk of prostate cancer (ORs between 0.84 and 1.15, p-values between 0.57 and 0.93) nor did they influence prostate cancer characteristics or survival. We conclude that men with a BARD1 mutation are not at elevated prostate cancer risk. It is not justified to inform men about increased prostate cancer risk in case of identification of a BARD1 mutation. However, a female relative of a man with a BARD1 mutation may benefit from this information and be tested for the mutation, because BARD1 is a breast cancer susceptibility gene. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results