1. Mutational Status of
- Author
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Sara, Lahoz, Adela, Rodríguez, Laia, Fernández, Teresa, Gorría, Reinaldo, Moreno, Francis, Esposito, Helena, Oliveres, Santiago, Albiol, Tamara, Saurí, David, Pesantez, Gisela, Riu, Miriam, Cuatrecasas, Pedro, Jares, Leire, Pedrosa, Estela, Pineda, Antonio, Postigo, Antoni, Castells, Aleix, Prat, Joan, Maurel, and Jordi, Camps
- Abstract
Next-generation sequencing (NGS) provides a molecular rationale to inform prognostic stratification and to guide personalized treatment in cancer patients. Here, we determined the prognostic and predictive value of actionable mutated genes in metastatic colorectal cancer (mCRC). Among a total of 294 mCRC tumors examined by targeted NGS, 200 of them derived from patients treated with first-line chemotherapy plus/minus monoclonal antibodies were included in prognostic analyses. Discriminative performance was assessed by time-dependent estimates of the area under the curve (AUC). The most recurrently mutated genes were
- Published
- 2022