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A new editorial paper published in Oncotarget discusses acute myeloid leukemia (AML), a type of aggressive cancer. The paper highlights recent advancements in understanding AML biology and the potential for developing novel drug therapies. The researchers suggest exploring reductive carboxylation as a possible drug target to weaken tumor cell survival mechanisms and improve patient outcomes. The paper provides further information on this topic and can be accessed through the provided DOI link. [Extracted from the article]

A recent editorial paper published in Oncotarget discusses the therapeutic potential and challenges of cytostatic persister cancer cells. These cells are able to remain viable despite treatment and can contribute to residual diseases and the emergence of resistant clones and relapses. Unlike resistant cells, persister cancer cells enter a non-proliferating state that is reversible upon treatment discontinuation. The paper highlights the need to understand the properties of cytostatic persisters and explores strategies for targeting them to reduce cancer recurrence. The researchers suggest that administering multiple targeted regimens may be necessary to effectively deplete the persister reservoirs in patients undergoing cancer treatments. [Extracted from the article]

A recent editorial paper published in Oncotarget discusses the molecular functions of regulatory genetic variants associated with cancer. The paper highlights the challenges in understanding the effects of genetic variants, such as their small effect size and their location in non-protein-coding regions of the genome. The researchers propose integrating genomic, epigenomic, transcriptomic, and machine learning methods to identify functional genetic variants and characterize their mode of action in regulating target genes. This approach has implications for cancer research and precision medicine. [Extracted from the article]

A research paper published in Oncotarget's Volume 15 discusses the differential expression of the Mad2 gene in human esophageal cancer. The study focuses on the relationship between the consumption of raw areca nut and the development of esophageal squamous cell carcinoma (ESCC). The researchers found that Mad2 expression levels were both overexpressed and underexpressed in the samples, leading to premature anaphase and chromosome missegregation. The study suggests that Mad2 expression levels, along with chromosomal abnormalities, could serve as a clinical biomarker for esophageal cancer. Further research is needed to understand the role of the pRb-E2F1 circuit in Mad2 down-regulation. [Extracted from the article]

A recent study conducted in Finland aimed to determine the frequency of NTRK gene fusion in patients with papillary thyroid cancer (PTC). The researchers identified patients with PTC from Finland's Auria Biobank and analyzed their genetic alterations, clinical characteristics, disease progression, and treatment pathways. The study found that NTRK gene fusion was infrequent in PTC patients, with only 1.5% of patients having the fusion. The study also demonstrated the feasibility of linking biobank samples to electronic health records to describe patient characteristics and outcomes. [Extracted from the article]

A research perspective published in Oncotarget's Volume 14 discusses the relationship between melatonin and carcinogenesis in mice. The study highlights the inhibitory effect of melatonin on cancer in vivo, specifically on transplantable mammary tumors in mice. It also demonstrates that melatonin administration at night inhibits chemically induced mammary carcinogenesis in mice and rats. The researchers emphasize the importance of timing in melatonin administration for its applications in oncology. The study provides valuable insights into the effects of melatonin on cancer in mice and highlights the need for further research in this area. [Extracted from the article]

"In the framework of the EX2TRICAN project, exploring unresolved extreme cancer phenotypes, we applied exome sequencing on rare familial cases with male breast cancer, identifying a novel pathogenic variant of ATR (p.Leu1808)." This work further demonstrates the interest of an extended genetic analysis such as exome sequencing to identify very rare variants that can play a role in cancer predisposition in extreme phenotype cancer cases unexplained by classical cancer gene panels testing. [Extracted from the article]