1. Treatment of the pregnant mother with cancer: A systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part II: Hematological tumors
- Author
-
Azim, Hatem A., Pavlidis, Nicholas, Peccatori, Fedro A., Pavlidis, Nicholas [0000-0002-2195-9961], Peccatori, Fedro A. [0000-0001-8227-8740], and Azim, Hatem A. [0000-0003-4344-777X]
- Subjects
Oncology ,Hematologic malignancy ,Dose-response relationship ,Pancytopenia ,Review ,Acute lymphoblastic leukemia ,Pregnancy ,Antineoplastic agents ,Treatment outcome ,Drug safety ,Melphalan ,Hypospadias ,Mercaptopurine ,Chronic myeloid leukemia ,Pregnancy Outcome ,Burkitt lymphoma ,General Medicine ,Environmental exposure ,Embryopathy ,Antineoplastic agent ,Promyelocytic leukemia ,Vincristine ,Cleft palate ,Granulocyte colony stimulating factor ,Hematologic Neoplasms ,Nonhodgkin lymphoma ,Immunotherapy ,Safety ,Rituximab ,Zidovudine ,Human ,medicine.medical_specialty ,Jaundice ,Antineoplastic Agents ,Bleomycin ,Pregnancy outcome ,Breast cancer ,Human immunodeficiency virus infection ,Dose response ,Retinoic acid ,Asparaginase ,Humans ,Cyclophosphamide ,Spontaneous abortion ,Heart atrium septum defect ,Gynecology ,Dose-Response Relationship, Drug ,Enterocolitis ,Cleft lip ,Methodology ,Tioguanine ,Leukopenia ,Growth retardation ,medicine.disease ,Cancer combination chemotherapy ,Acute granulocytic leukemia ,B cell lymphoma ,Methotrexate ,chemistry ,Procarbazine ,Imatinib ,Blood disease ,Disseminated intravascular clotting ,Hemolytic anemia ,Mitoxantrone ,Idarubicin ,Leukemia in pregnancy ,Lymphoma in pregnancy ,Down syndrome ,Meningocele ,chemistry.chemical_compound ,Teratogenicity ,Hydroxyurea ,Pylorus stenosis ,Hematologic neoplasms ,Cervical cancer ,Fetus death ,Antibiotic agent ,Cytarabine ,Gastroenteritis ,Dacarbazine ,Treatment Outcome ,Immunosuppressive agent ,Lamivudine ,Cancer radiotherapy ,Female ,Drug ,Immunosuppressive agents ,Pregnancy Complications, Neoplastic ,Immunosuppressive Agents ,Hydrocephalus ,Hodgkin disease ,Cardiomyopathy ,Umbilical hernia ,Vinblastine ,Alpha interferon ,Pregnancy complication ,Internal medicine ,medicine ,Chemotherapy ,Radiology, Nuclear Medicine and imaging ,Lung cancer ,Busulfan ,Fetus distress ,Neoplastic ,business.industry ,Daunorubicin ,Chlormethine ,Cancer ,Drug efficacy ,Polydactyly ,Pregnancy complications ,Doxorubicin ,Systematic review ,Thumb malformation ,Prednisone ,Congenital malformation ,Warfarin ,Unindexed drug ,Ovarian cancer ,business - Abstract
The association of cancer and pregnancy is increasingly encountered nowadays in clinical practice. Due to the relative rarity of the situation, it lacks a systematized approach. Different systemic therapies are used in managing cancer with uncertainty regarding the potential hazards they could pose on the pregnancy and/or the fetus. We have performed a systematic review of literature to identify all reports addressing cancer patients who were exposed to any of the known systemic therapies during the course of the pregnancy. The results were discussed in two parts; part I addresses pregnant patients with solid tumors while part I for those with hematological malignancies. In part I, we identified different solid tumors diagnosed and treated during the course of pregnancy. Breast cancer was the most commonly treated followed by ovarian cancer. Other tumors were treated as well including lung cancer, cervical cancer, sarcoma and melanomas. It is important to acknowledge the intent of therapy (palliative vs. curative) and the patients has to be properly counseled to reach an informed decision. We aim to provide a more robust consensus on how to approach these cases and provide a higher degree of evidence to support the safety of applying certain management strategies over the other.
- Published
- 2010