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Start Over Author "Yamada, Tesshi" Journal cancer science
12 results on '"Yamada, Tesshi"'

2. Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray

Author

Murakoshi, Yusuke, Honda, Kazufumi, Sasazuki, Shizuka, Ono, Masaya, Negishi, Ayako, Matsubara, Junichi, Sakuma, Tomohiro, Kuwabara, Hideya, Nakamori, Shoji, Sata, Naohiro, Nagai, Hideo, Ioka, Tatsuya, Okusaka, Takuji, Kosuge, Tomoo, Shimahara, Masashi, Yasunami, Yohichi, Ino, Yoshinori, Tsuchida, Akihiko, Aoki, Tatsuya, Tsugane, Shoichiro, and Yamada, Tesshi

Published
2011
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10. Plasma biomarker discovery and validation for colorectal cancer by quantitative shotgun mass spectrometry and protein microarray

Author

Murakoshi, Yusuke, primary, Honda, Kazufumi, additional, Sasazuki, Shizuka, additional, Ono, Masaya, additional, Negishi, Ayako, additional, Matsubara, Junichi, additional, Sakuma, Tomohiro, additional, Kuwabara, Hideya, additional, Nakamori, Shoji, additional, Sata, Naohiro, additional, Nagai, Hideo, additional, Ioka, Tatsuya, additional, Okusaka, Takuji, additional, Kosuge, Tomoo, additional, Shimahara, Masashi, additional, Yasunami, Yohichi, additional, Ino, Yoshinori, additional, Tsuchida, Akihiko, additional, Aoki, Tatsuya, additional, Tsugane, Shoichiro, additional, and Yamada, Tesshi, additional

Published
2010
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12. Increased susceptibility of Sf1+/– mice to azoxymethane-induced colon tumorigenesis.

Author

Shitashige, Miki, Satow, Reiko, Honda, Kazufumi, Ono, Masaya, Hirohashi, Setsuo, and Yamada, Tesshi

Abstract

Aberrant transactivation of a certain set of target genes by the β-catenin and T-cell factor-4 nuclear complex has been considered crucial for the initiation of colorectal carcinogenesis. We previously identified splicing factor-1 (SF1) as a novel component of the β-catenin and T-cell factor-4 complex, and showed that the overexpression of SF1 inhibited the gene transactivational activity of the complex and markedly suppressed β-catenin-evoked colony formation by human embryonic kidney 293 cells. However, the involvement of SF1 in the process of carcinogenesis in vivo remains unclear. In the present study, we established SF1-knockout mice using the gene trapping method. Homozygous mice ( Sf1−/–) died during embryonic development before embryonic day (E)8.5, whereas heterozygous ( Sf1+/–) mice were born alive and developed normally. Azoxymethane (AOM) was given at a dose of 10 mg/kg body weight once a week for 6 weeks to 7-week-old Sf1+/– and Sf1+/+ mice. At 23 weeks after the start of AOM the average number (5.5 ± 0.6 versus 2.2 ± 0.2 in females [ P = 0.003, Mann–Whitney U-test], 3.7 ± 0.2 versus 1.7 ± 0.7 in males [ P = 0.014]) and volume of colon tumors per mouse (8.7 ± 1.6 versus 2.2 ± 0.5 mm3 per female [ P = 0.0008], 11.3 ± 3.4 versus 0.6 ± 0.2 mm3 per male [ P = 0.001]) were significantly higher in Sf1+/– than in Sf1+/+ mice. The increased susceptibility of Sf1+/– mice to AOM-induced colon tumorigenesis indicates the crucial involvement of SF1 in the β-catenin-mediated regulation of proliferation and differentiation of intestinal epithelial cells. ( Cancer Sci 2007; 98: 1862–1867) [ABSTRACT FROM AUTHOR]

Published
2007
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