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Your search keyword '"Tanikawa Michihiro"' showing total 8 results
Start Over Author "Tanikawa Michihiro" Journal cancer science
8 results on '"Tanikawa Michihiro"'

1. Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids

Author

Toyohara, Yusuke, primary, Taguchi, Ayumi, additional, Ishii, Yoshiyuki, additional, Yoshimoto, Daisuke, additional, Yamazaki, Miki, additional, Matsunaga, Hiroko, additional, Nakatani, Kazuma, additional, Hoshi, Daisuke, additional, Tsuchimochi, Saki, additional, Kusakabe, Misako, additional, Baba, Satoshi, additional, Kawata, Akira, additional, Ikemura, Masako, additional, Tanikawa, Michihiro, additional, Sone, Kenbun, additional, Uchino‐Mori, Mayuyo, additional, Ushiku, Tetsuo, additional, Takeyama, Haruko, additional, Oda, Katsutoshi, additional, Kawana, Kei, additional, Hippo, Yoshitaka, additional, and Osuga, Yutaka, additional

Published
2023
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2. Identification of target cells of human papillomavirus 18 using squamocolumnar junction organoids.

Author

Toyohara, Yusuke, Taguchi, Ayumi, Ishii, Yoshiyuki, Yoshimoto, Daisuke, Yamazaki, Miki, Matsunaga, Hiroko, Nakatani, Kazuma, Hoshi, Daisuke, Tsuchimochi, Saki, Kusakabe, Misako, Baba, Satoshi, Kawata, Akira, Ikemura, Masako, Tanikawa, Michihiro, Sone, Kenbun, Uchino‐Mori, Mayuyo, Ushiku, Tetsuo, Takeyama, Haruko, Oda, Katsutoshi, and Kawana, Kei

Abstract

Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high‐risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence in adenocarcinomas. The cellular targets and molecular mechanisms underlying its infection remain unclear. In this study, we aimed to identify the cells targeted by HPV18 and elucidate the molecular mechanisms underlying HPV18 replication. Initially, we established a lentiviral vector (HPV18LCR‐GFP vector) containing the HPV18 long control region promoter located upstream of EGFP. Subsequently, HPV18LCR‐GFP vectors were transduced into patient‐derived squamocolumnar junction organoids, and the presence of GFP‐positive cells was evaluated. Single‐cell RNA sequencing of GFP‐positive and GFP‐negative cells was conducted. Differentially expressed gene analysis revealed that 169 and 484 genes were significantly upregulated in GFP‐positive and GFP‐negative cells, respectively. Pathway analysis showed that pathways associated with cell cycle and viral carcinogenesis were upregulated in GFP‐positive cells, whereas keratinization and mitophagy/autophagy‐related pathways were upregulated in GFP‐negative cells. siRNA‐mediated luciferase reporter assay and HPV18 genome replication assay validated that, among the upregulated genes, ADNP, FHL2, and NPM3 were significantly associated with the activation of the HPV18 early promoter and maintenance of the HPV18 genome. Among them, NPM3 showed substantially higher expression in HPV‐related cervical adenocarcinomas than in squamous cell carcinomas, and NPM3 knockdown of HPV18‐infected cells downregulated stem cell‐related genes. Our new experimental model allows us to identify novel genes involved in HPV18 early promoter activities. These molecules might serve as therapeutic targets in HPV18‐infected cervical lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan

Author

Kage, Hidenori, primary, Shinozaki‐Ushiku, Aya, additional, Ishigaki, Kazunaga, additional, Sato, Yusuke, additional, Tanabe, Masahiko, additional, Tanaka, Shota, additional, Tanikawa, Michihiro, additional, Watanabe, Kousuke, additional, Kato, Shingo, additional, Akagi, Kiwamu, additional, Uchino, Keita, additional, Mitani, Kinuko, additional, Takahashi, Shunji, additional, Miura, Yuji, additional, Ikeda, Sadakatsu, additional, Kojima, Yasushi, additional, Watanabe, Kiyotaka, additional, Mochizuki, Hitoshi, additional, Yamaguchi, Hironori, additional, Kawazoe, Yoshimasa, additional, Kashiwabara, Kosuke, additional, Kohsaka, Shinji, additional, Tatsuno, Kenji, additional, Ushiku, Tetsuo, additional, Ohe, Kazuhiko, additional, Yatomi, Yutaka, additional, Seto, Yasuyuki, additional, Aburatani, Hiroyuki, additional, Mano, Hiroyuki, additional, Miyagawa, Kiyoshi, additional, and Oda, Katsutoshi, additional

Published
2023
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4. Cells with stem‐like properties are associated with the development of HPV18 ‐positive cervical cancer

Author

Kusakabe, Misako, primary, Taguchi, Ayumi, additional, Tanikawa, Michihiro, additional, Wagatsuma, Ryota, additional, Yamazaki, Miki, additional, Tsuchimochi, Saki, additional, Toyohara, Yusuke, additional, Kawata, Akira, additional, Baba, Satoshi, additional, Ueno, Toshihide, additional, Sone, Kenbun, additional, Mori‐Uchino, Mayuyo, additional, Ikemura, Masako, additional, Matsunaga, Hiroko, additional, Nagamatsu, Takeshi, additional, Wada‐Hiraike, Osamu, additional, Kawazu, Masahito, additional, Ushiku, Tetsuo, additional, Takeyama, Haruko, additional, Oda, Katsutoshi, additional, Kawana, Kei, additional, Mano, Hiroyuki, additional, and Osuga, Yutaka, additional

Published
2022
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5. Cells with stem‐like properties are associated with the development of HPV18‐positive cervical cancer.

Author

Kusakabe, Misako, Taguchi, Ayumi, Tanikawa, Michihiro, Wagatsuma, Ryota, Yamazaki, Miki, Tsuchimochi, Saki, Toyohara, Yusuke, Kawata, Akira, Baba, Satoshi, Ueno, Toshihide, Sone, Kenbun, Mori‐Uchino, Mayuyo, Ikemura, Masako, Matsunaga, Hiroko, Nagamatsu, Takeshi, Wada‐Hiraike, Osamu, Kawazu, Masahito, Ushiku, Tetsuo, Takeyama, Haruko, and Oda, Katsutoshi

Abstract

The cellular origins of cervical cancer and the histological differentiation of human papillomavirus (HPV)‐infected cells remain unexplained. To gain new insights into the carcinogenesis and histological differentiation of HPV‐associated cervical cancer, we focused on cervical cancer with mixed histological types. We conducted genomic and transcriptomic analyses of cervical cancers with mixed histological types. The commonality of the cellular origins of these cancers was inferred using phylogenetic analysis and by assessing the HPV integration sites. Carcinogenesis was estimated by analyzing human gene expression profiles in different histological types. Among 42 cervical cancers with known HPV types, mixed histological types were detected in four cases, and three of them were HPV18‐positive. Phylogenetic analysis of these three cases revealed that the different histological types had a common cell of origin. Moreover, the HPV‐derived transcriptome and HPV integration sites were common among different histological types, suggesting that HPV integration could occur before differentiation into each histological type. Human gene expression profiles indicated that HPV18‐positive cancer retained immunologically cold components with stem cell properties. Mixed cervical cancer has a common cellular origin among different histological types, and progenitor cells with stem‐like properties may be associated with the development of HPV18‐positive cervical cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers

Author

Yamaguchi, Kohei, primary, Matsumoto, Yoko, additional, Suzuki, Ryo, additional, Nishida, Haruka, additional, Omata, Daiki, additional, Inaba, Hirofumi, additional, Kukita, Asako, additional, Tanikawa, Michihiro, additional, Sone, Kenbun, additional, Oda, Katsutoshi, additional, Osuga, Yutaka, additional, Maruyama, Kazuo, additional, and Fujii, Tomoyuki, additional

Published
2021
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7. Effect of murine double‐minute 2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys

Author

Kawata, Yoshiko, primary, Nagasaka, Kazunori, additional, Oda, Katsutoshi, additional, Makii, Chinami, additional, Takeuchi, Makoto, additional, Oki, Shinya, additional, Honjo, Harunori, additional, Kojima, Machiko, additional, Miyagawa, Yuko, additional, Taguchi, Ayumi, additional, Tanikawa, Michihiro, additional, Sone, Kenbun, additional, Hiraike, Haruko, additional, Matsumoto, Yoko, additional, Wada‐Hiraike, Osamu, additional, Ayabe, Takuya, additional, Osuga, Yutaka, additional, and Fujii, Tomoyuki, additional

Published
2020
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8. Interleukin‐17 is associated with expression of programmed cell death 1 ligand 1 in ovarian carcinoma

Author

Aotsuka, Aeri, primary, Matsumoto, Yoko, additional, Arimoto, Takahide, additional, Kawata, Akira, additional, Ogishima, Juri, additional, Taguchi, Ayumi, additional, Tanikawa, Michihiro, additional, Sone, Kenbun, additional, Mori‐Uchino, Mayuyo, additional, Tsuruga, Tetsushi, additional, Oda, Katsutoshi, additional, Kawana, Kei, additional, Osuga, Yutaka, additional, and Fujii, Tomoyuki, additional

Published
2019
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