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Your search keyword '"Yang, Xiao-Yi"' showing total 10 results
Start Over Author "Yang, Xiao-Yi" Journal cancer research
10 results on '"Yang, Xiao-Yi"'

2. Abstract P2-20-11: Progesterone impacts the growth and immune cell infiltration of murine mammary gland tumors

Author

Werner, Lauryn R, primary, Helm, Dominika E., additional, Tinoco, Julio, additional, Chowanec, Eilidh I, additional, Holloran, Sean M, additional, Hastings, Richard C, additional, Wei, Junping, additional, Lei, Gangjun, additional, Yang, Xiao-Yi, additional, Markiewicz, Mary A, additional, Chalise, Prabhakar, additional, Balko, Justin, additional, Hartman, Zachary C, additional, and Hagan, Christy R, additional

Published
2023
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3. Abstract 1351: Lauryn Werner

Author

Werner, Lauryn Rose, primary, Gibson, Katelin A., additional, Goodman, Merit L., additional, Helm, Dominika E., additional, Walter, Katherine R., additional, Holloran, Sean M., additional, Trinca, Gloria M., additional, Hastings, Richard C., additional, Yang, Howard H., additional, Hu, Ying, additional, Wei, Junping, additional, Lei, Gangjun, additional, Yang, Xiao-Yi, additional, Madan, Rashna, additional, Molinolo, Alfredo A., additional, Markiewicz, Mary A., additional, Chalise, Prabhakar, additional, Axelrod, Margaret L., additional, Balko, Justin M., additional, Hunter, Kent W., additional, Hartman, Zachary C., additional, Lange, Carol A., additional, and Hagan, Christy R., additional

Published
2022
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4. Abstract 3531: Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Author

Hwang, Bin-Jin, primary, Tsao, Li-Chung, additional, Acharya, Chaitanya, additional, Trotter, Timothy, additional, Agarwal, Pankaj, additional, Wang, Tao, additional, Wei, Junping, additional, Yang, Xiao-Yi, additional, Lei, Gang-jun, additional, Osada, Takuya, additional, Lyerly, Herbert Kim, additional, Morse, Michael A., additional, and Hartman, Zachary, additional

Published
2022
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5. Abstract P4-04-07: Progesterone promotes immunomodulation and tumor development in the murine mammary gland

Author

Werner, Lauryn R, primary, Gibson, Katelin A, additional, Goodman, Merit L, additional, Helm, Dominika E, additional, Walter, Katherine R, additional, Holloran, Sean M, additional, Trinca, Gloria M, additional, Hastings, Richard C, additional, Yang, Howard H, additional, Hu, Ying, additional, Wei, Junping, additional, Lei, Gangjun, additional, Yang, Xiao-Yi, additional, Madan, Rashna, additional, Molinolo, Alfred A, additional, Markiewicz, Mary A, additional, Chalise, Prabhakar, additional, Axelrod, Margaret L, additional, Balko, Justin M, additional, Hunter, Kent W, additional, Hartman, Zachary C, additional, Lange, Carol A, additional, and Hagan, Christy R, additional

Published
2022
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6. IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils

Author

Trotter, Timothy N., primary, Shuptrine, Casey W., additional, Tsao, Li-Chung, additional, Marek, Robert D., additional, Acharya, Chaitanya, additional, Wei, Jun-Ping, additional, Yang, Xiao-Yi, additional, Lei, Gangjun, additional, Wang, Tao, additional, Lyerly, Herbert Kim, additional, and Hartman, Zachary C., additional

Published
2020
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10. The cis decoy against the estrogen response element suppresses breast cancer cells via target disrupting c-fos not mitogen-activated protein kinase activity.

Author

Wang LH, Yang XY, Zhang X, Mihalic K, Xiao W, and Farrar WL

Subjects
Apoptosis drug effects, Apoptosis physiology, Breast Neoplasms enzymology, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Division drug effects, Cell Division physiology, DNA, Neoplasm genetics, DNA, Neoplasm metabolism, Enzyme Activation, Estradiol pharmacology, Gene Expression Regulation, Neoplastic, Humans, Mitogen-Activated Protein Kinase 3, Oligonucleotides genetics, Receptors, Estrogen antagonists & inhibitors, Receptors, Estrogen metabolism, Response Elements genetics, Transcriptional Activation drug effects, Transcriptional Activation genetics, Transfection, Tumor Cells, Cultured, Breast Neoplasms genetics, Genes, fos genetics, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinases metabolism, Oligonucleotides pharmacology, Phosphates pharmacology, Receptors, Estrogen genetics
Abstract

Breast cancer, the most common malignancy in women, has been demonstrated to be associated with the steroid hormone estrogen and its receptor (ER), a ligand-activated transcription factor. Therefore, we developed a phosphorothiolate cis-element decoy against the estrogen response element (ERE decoy) to target disruption of ER DNA binding and transcriptional activity. Here, we showed that the ERE decoy potently ablated the 17beta-estrogen-inducible cell proliferation and induced apoptosis of human breast carcinoma cells by functionally affecting expression of c-fos gene and AP-1 luciferase gene reporter activity. Specificity of the decoy was demonstrated by its ability to directly block ER binding to a cis-element probe and transactivation. Moreover, the decoy failed to inhibit ER-mediated mitogen-activated protein kinase signaling pathways and cell growth of ER-negative breast cancer cells. Taken together, these data suggest that estrogen-mediated cell growth of breast cancer cells can be preferentially restricted via targeted disruption of ER at the level of DNA binding by a novel and specific decoy strategy applied to steroid nuclear receptors.

Published
2003

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