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Your search keyword '"West, Alison"' showing total 6 results
Start Over Author "West, Alison" Journal cancer research
6 results on '"West, Alison"'

2. Inflammasome Adaptor ASC Suppresses Apoptosis of Gastric Cancer Cells by an IL18-Mediated Inflammation-Independent Mechanism

Author

Deswaerte, Virginie, primary, Nguyen, Paul, additional, West, Alison, additional, Browning, Alison F., additional, Yu, Liang, additional, Ruwanpura, Saleela M., additional, Balic, Jesse, additional, Livis, Thaleia, additional, Girard, Charlotte, additional, Preaudet, Adele, additional, Oshima, Hiroko, additional, Fung, Ka Yee, additional, Tye, Hazel, additional, Najdovska, Meri, additional, Ernst, Matthias, additional, Oshima, Masanobu, additional, Gabay, Cem, additional, Putoczki, Tracy, additional, and Jenkins, Brendan J., additional

Published
2018
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5. Oncolytic Virus and Anti–4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer

Author

John, Liza B., primary, Howland, Linda J., additional, Flynn, Jacqueline K., additional, West, Alison C., additional, Devaud, Christel, additional, Duong, Connie P., additional, Stewart, Trina J., additional, Westwood, Jenny A., additional, Guo, Z. Sheng, additional, Bartlett, David L., additional, Smyth, Mark J., additional, Kershaw, Michael H., additional, and Darcy, Phillip K., additional

Published
2012
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6. A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3.

Author

Oh JJ, West AR, Fishbein MC, and Slamon DJ

Subjects
Amino Acid Sequence, Animals, Breast Neoplasms genetics, Breast Neoplasms metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Cell Division genetics, Humans, Lung Neoplasms metabolism, Mice, Mice, Nude, Molecular Sequence Data, RNA, Messenger biosynthesis, RNA, Messenger genetics, Receptor, ErbB-2 biosynthesis, Transfection, Carcinoma, Non-Small-Cell Lung genetics, Chromosomes, Human, Pair 3 genetics, Genes, Tumor Suppressor, Lung Neoplasms genetics, Receptor, ErbB-2 genetics
Abstract

Frequent allelic loss and homozygous deletions within chromosome 3p in human lung cancers have suggested that the 3p21.3 (370-kb) region contains a critical tumor suppressor gene(s) (TSG). With the exact identity/characteristics of such a gene(s) still unconfirmed, a lack of inactivating structural mutations in the expressed genes contained within this region may indicate that the 3p TSG(s) do not fit into the classical "two-mutation" model. This report characterizes a candidate 3p TSG, H37, located within the 370-kb region. Reduced expression of the H37 transcript was found in 9 of 11 (82%) of primary non-small cell lung cancers (NSCLCs) when compared with adjacent normal tissues. Generation of an H37 antibody followed by immunohistochemical analysis of primary NSCLC specimens demonstrated that 46 of 62 (73%) of these cancers contain reduced levels of H37 protein when compared with adjacent normal bronchial cells. Moreover, introduction of the H37 cDNA into human breast cancer cells deleted of 3p21-22 reduced both anchorage-dependent and -independent cell growth in vitro. Subsequent transfection of H37 cDNA into one of the human lung cancer cell lines homozygously deleted in this region resulted in a very low yield of H37-expressing clones. H37 also suppressed anchorage-dependent and -independent growth of A9 mouse fibrosarcoma cells and inhibited tumor formation in nude mice. These data indicate a potential role for H37 as one of the 3p TSGs in human lung cancer.

Published
2002

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