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Your search keyword '"Thompson, Elizabeth D."' showing total 6 results
Start Over Author "Thompson, Elizabeth D." Journal cancer research
6 results on '"Thompson, Elizabeth D."'

3. Abstract PR-004: Systemic and intratumoral immune profiling in metastatic pancreatic cancer patients who received front-line FOLFIRINOX and were treated with combination immunotherapy with CTLA-4 blockade in the maintenance setting

Author

Wu, Annie A., primary, Bever, Katherine M., additional, Ho, Won Jin, additional, Fertig, Elana J., additional, Niu, Nan, additional, Zheng, Lei, additional, Parkinson, Rose M., additional, Durham, Jennifer N., additional, Onners, Beth, additional, Ferguson, Anna K., additional, Wilt, Cara, additional, Ko, Andrew H., additional, Wang-Gillam, Andrea, additional, Laheru, Daniel A., additional, Anders, Robert A., additional, Thompson, Elizabeth D., additional, Sugar, Elizabeth A., additional, Jaffee, Elizabeth M., additional, and Le, Dung T., additional

Published
2020
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4. Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome

Author

Huang, Wenjie, primary, Navarro-Serer, Bernat, additional, Jeong, Yea Ji, additional, Chianchiano, Peter, additional, Xia, Limin, additional, Luchini, Claudio, additional, Veronese, Nicola, additional, Dowiak, Cameron, additional, Ng, Tammy, additional, Trujillo, Maria A., additional, Huang, Bo, additional, Pflüger, Michael J., additional, Macgregor-Das, Anne M., additional, Lionheart, Gemma, additional, Jones, Danielle, additional, Fujikura, Kohei, additional, Nguyen-Ngoc, Kim-Vy, additional, Neumann, Neil M., additional, Groot, Vincent P., additional, Hasanain, Alina, additional, van Oosten, A. Floortje, additional, Fischer, Sandra E., additional, Gallinger, Steven, additional, Singhi, Aatur D., additional, Zureikat, Amer H., additional, Brand, Randall E., additional, Gaida, Matthias M., additional, Heinrich, Stefan, additional, Burkhart, Richard A., additional, He, Jin, additional, Wolfgang, Christopher L., additional, Goggins, Michael G., additional, Thompson, Elizabeth D., additional, Roberts, Nicholas J., additional, Ewald, Andrew J., additional, and Wood, Laura D., additional

Published
2020
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6. Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression.

Author

Zabransky DJ, Chhabra Y, Fane ME, Kartalia E, Leatherman JM, Hüser L, Zimmerman JW, Delitto D, Han S, Armstrong TD, Charmsaz S, Guinn S, Pramod S, Thompson ED, Hughes SJ, O'Connell J, Egan JM, Jaffee EM, and Weeraratna AT

Subjects
Animals, Mice, Growth Differentiation Factor 15 genetics, Growth Differentiation Factor 15 therapeutic use, Proto-Oncogene Proteins c-akt, Pancreas pathology, Fibroblasts pathology, Tumor Microenvironment, Cell Line, Tumor, Pancreatic Neoplasms pathology, Cancer-Associated Fibroblasts pathology
Abstract

Pancreatic cancer is more prevalent in older individuals and often carries a poorer prognosis for them. The relationship between the microenvironment and pancreatic cancer is multifactorial, and age-related changes in nonmalignant cells in the tumor microenvironment may play a key role in promoting cancer aggressiveness. Because fibroblasts have profound impacts on pancreatic cancer progression, we investigated whether age-related changes in pancreatic fibroblasts influence cancer growth and metastasis. Proteomics analysis revealed that aged fibroblasts secrete different factors than young fibroblasts, including increased growth/differentiation factor 15 (GDF-15). Treating young mice with GDF-15 enhanced tumor growth, whereas aged GDF-15 knockout mice showed reduced tumor growth. GDF-15 activated AKT, rendering tumors sensitive to AKT inhibition in an aged but not young microenvironment. These data provide evidence for how aging alters pancreatic fibroblasts and promotes tumor progression, providing potential therapeutic targets and avenues for studying pancreatic cancer while accounting for the effects of aging., Significance: Aged pancreatic fibroblasts secrete GDF-15 and activate AKT signaling to promote pancreatic cancer growth, highlighting the critical role of aging-mediated changes in the pancreatic cancer microenvironment in driving tumor progression. See related commentary by Isaacson et al., p. 1185., (©2024 American Association for Cancer Research.)

Published
2024
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