1. Abstract 4735: Role of myeloid derived suppressor cells in promoting ovarian cancer
- Author
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Sharif Sakr, Thomas E. Buekers, Robert T. Morris, Adnan R. Munkarah, Shailendra Giri, Ramandeep Rattan, and Raymond Quiles
- Subjects
Cancer Research ,Poor prognosis ,Angiogenesis ,business.industry ,medicine.medical_treatment ,Cancer ,Immunotherapy ,medicine.disease ,Metastasis ,Oncology ,medicine ,Cancer research ,Myeloid-derived Suppressor Cell ,Syngeneic mouse ,Ovarian cancer ,business - Abstract
Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that are increased in tumors and create an immunosuppressive environment by inhibiting the T-cell function. In addition, MDSCs promote angiogenesis, tumor invasion, and metastasis. Increased MDSC accumulation in epithelial ovarian cancer (EOC) has been associated with poor prognosis. Our study investigated whether depletion of MDSCs will influence EOC progression and enhance the therapeutic response of programmed death-1 (PD1) immunotherapy. The intraperitoneal ID8-luciferase syngeneic mouse epithelial ovarian cancer cell model in B6 mice was used for the study ID8 bearing mice exhibited significantly higher levels of MDSCs (CD11bGr1+) (p Citation Format: Ramandeep Rattan, Sharif Sakr, Raymond Quiles, Robert Morris, Thomas Buekers, Adnan Munkarah, Shailendra Giri. Role of myeloid derived suppressor cells in promoting ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4735.
- Published
- 2018