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Your search keyword '"Prior, Julie L."' showing total 7 results
Start Over Author "Prior, Julie L." Journal cancer research
7 results on '"Prior, Julie L."'

1. Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, additional, Highkin, Maureen, additional, Vemalapally, Nagalaxmi, additional, Jin, Xiaohua, additional, Zhou, Brandon, additional, Prior, Julie L., additional, Tipton, Ashley R., additional, Li, Shunqiang, additional, Iliuk, Anton, additional, Achilefu, Samuel, additional, Hagemann, Ian S., additional, Edwards, John R., additional, and Bose, Ron, additional

Published
2023
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2. Abstract 5778: Breast cancer mutations HER2V777L and PIK3CAH1047R activate the p21-CDK4/6 -Cyclin D1 axis driving tumorigenesis and drug resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, additional, Highkin, Maureen, additional, Vemalapally, Nagalaxmi, additional, Jin, Xiaohua, additional, Zhou, Brandon, additional, Prior, Julie L., additional, Tipton, Ashley R., additional, Li, Shunqiang, additional, Iliuk, Anton, additional, Achilefu, Samuel, additional, Hagemann, Ian S., additional, Edwards, John, additional, and Bose, Ron, additional

Published
2023
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3. Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., additional, Xiang, Jingyu, additional, Su, Xinming, additional, Chen, Sara, additional, Schneider, Jochen, additional, Joeng, Kyu-Sang, additional, Vidal, Marcos, additional, Goldberg, Leah, additional, Deng, Hongju, additional, Hornick, Mary C., additional, Prior, Julie L., additional, Piwnica-Worms, David, additional, Long, Fanxin, additional, Cagan, Ross, additional, and Weilbaecher, Katherine N., additional

Published
2012
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4. CD47 Regulates Bone Mass and Tumor Metastasis to Bone

Author

Uluçkan, Özge, primary, Becker, Stephanie N., additional, Deng, Hongju, additional, Zou, Wei, additional, Prior, Julie L., additional, Piwnica-Worms, David, additional, Frazier, William A., additional, and Weilbaecher, Katherine N., additional

Published
2009
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5. Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth

Author

Pazolli, Ermira, primary, Luo, Xianmin, additional, Brehm, Sarah, additional, Carbery, Kelly, additional, Chung, Jun-Jae, additional, Prior, Julie L., additional, Doherty, Jason, additional, Demehri, Shadmehr, additional, Salavaggione, Lorena, additional, Piwnica-Worms, David, additional, and Stewart, Sheila A., additional

Published
2009
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7. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo.

Author

Luker GD, Sharma V, Pica CM, Prior JL, Li W, and Piwnica-Worms D

Subjects
Acyclovir pharmacokinetics, Animals, Antigens, Viral, Tumor biosynthesis, Antigens, Viral, Tumor genetics, Green Fluorescent Proteins, Guanine, HeLa Cells, Humans, Image Processing, Computer-Assisted methods, Luminescent Proteins biosynthesis, Luminescent Proteins genetics, Mice, Mice, Nude, Microscopy, Fluorescence, Recombinant Fusion Proteins biosynthesis, Recombinant Fusion Proteins genetics, Recombinant Fusion Proteins metabolism, Thymidine Kinase biosynthesis, Thymidine Kinase genetics, Tomography, Emission-Computed methods, Transfection, Tritium, Tumor Suppressor Protein p53 biosynthesis, Tumor Suppressor Protein p53 genetics, Acyclovir analogs & derivatives, Antigens, Viral, Tumor metabolism, Tumor Suppressor Protein p53 metabolism
Abstract

Protein-protein interactions control essential steps in signal transduction pathways and other intracellular processes, and assembly of protein complexes modulates and responds to the regulatory events that exist in living animals. We have used microPET and fluorescence imaging to detect interactions between p53 tumor suppressor and large T antigen (TAg) of SV40 virus in a tetracycline-inducible two-hybrid system. To additionally validate this molecular imaging technique, we investigated whether expression of the reporter gene, comprised of a mutant thymidine kinase from herpes simplex virus 1 fused to green fluorescent protein could quantify relative differences in amounts of interacting hybrid proteins. In HeLa cells stably transfected with the reporter gene and interacting (p53-TAg) or noninteracting (p53 and polyoma virus coat protein) pairs of proteins, treatment with doxycycline produced time- and dose-dependent increases in expression of hybrid proteins. Proportional increases in amounts of reporter gene were produced only in cells expressing p53 and TAg. In mice bearing xenografts of these stably transfected HeLa cells, amounts of hybrid proteins were regulated with doxycycline. Both microPET imaging and biodistribution studies showed time- and dose-dependent increases in accumulation of the reporter substrate 9-(4-[(18)F]-fluoro-3-hydroxymethylbutyl)guanine only in p53-TAg tumors. Fluorescence microscopy of excised tumors also showed corresponding changes in expression of the fusion reporter gene in response to binding of p53 and TAg. These data demonstrate that the imaging two-hybrid system responds in a proportional fashion to increasing amounts of interacting proteins in vivo.

Published
2003

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