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Your search keyword '"Nambiar, Dhanya"' showing total 9 results
Start Over Author "Nambiar, Dhanya" Journal cancer research
9 results on '"Nambiar, Dhanya"'

1. Galectin-1 Mediates Chronic STING Activation in Tumors to Promote Metastasis through MDSC Recruitment

Author

Nambiar, Dhanya K., primary, Viswanathan, Vignesh, additional, Cao, Hongbin, additional, Zhang, Weiruo, additional, Guan, Li, additional, Chamoli, Manish, additional, Holmes, Brittany, additional, Kong, Christina, additional, Hildebrand, Rachel, additional, Koong, Amanda Jeanette, additional, von Eyben, Rie, additional, Plevritis, Sylvia, additional, Li, Lingyin, additional, Giaccia, Amato, additional, Engleman, Edgar, additional, and Le, Quynh Thu, additional

Published
2023
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2. Abstract 66: Galectin-1 mediated chronic tumoral-STING activation promotes metastasisthrough MDSC recruitment

Author

Nambiar, Dhanya K., primary, Viswanathan, Vignesh Vignesh, additional, Cao, Hongbin, additional, Zhang, Weiruo, additional, Guan, Li, additional, Chamoli, Manish, additional, Holmes, Brittany, additional, Kong, Christina, additional, Hildebrand, Rachel, additional, Koong, Amanda, additional, Eyben, Rie, additional, Giaccia, Amato, additional, Li, Lingyin, additional, Engleman, Edgar, additional, and Le, Quynh Thu, additional

Published
2023
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3. NFE2L2Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells

Author

Guan, Li, primary, Nambiar, Dhanya K., additional, Cao, Hongbin, additional, Viswanathan, Vignesh, additional, Kwok, Shirley, additional, Hui, Angela B., additional, Hou, Yuan, additional, Hildebrand, Rachel, additional, von Eyben, Rie, additional, Holmes, Brittany J., additional, Zhao, Junfei, additional, Kong, Christina S., additional, Wamsley, Nathan, additional, Zhang, Weiruo, additional, Major, Michael B., additional, Seol, Seung W., additional, Sunwoo, John B., additional, Hayes, D. Neil, additional, Diehn, Maximilian, additional, and Le, Quynh-Thu, additional

Published
2023
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9. NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells.

Author

Guan L, Nambiar DK, Cao H, Viswanathan V, Kwok S, Hui AB, Hou Y, Hildebrand R, von Eyben R, Holmes BJ, Zhao J, Kong CS, Wamsley N, Zhang W, Major MB, Seol SW, Sunwoo JB, Hayes DN, Diehn M, and Le QT

Subjects
Animals, Mice, Glutaminase metabolism, Mutation, NF-E2-Related Factor 2 genetics, NF-E2-Related Factor 2 metabolism, Radiation Tolerance genetics, Squamous Cell Carcinoma of Head and Neck genetics, Squamous Cell Carcinoma of Head and Neck radiotherapy, Squamous Cell Carcinoma of Head and Neck metabolism, Humans, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell pathology, Head and Neck Neoplasms genetics, Head and Neck Neoplasms radiotherapy, Head and Neck Neoplasms metabolism, Myeloid-Derived Suppressor Cells metabolism
Abstract

Radiotherapy (RT) is one of the primary treatments of head and neck squamous cell carcinoma (HNSCC), which has a high-risk of locoregional failure (LRF). Presently, there is no reliable predictive biomarker of radioresistance in HNSCC. Here, we found that mutations in NFE2L2, which encodes Nrf2, are associated with a significantly higher rate of LRF in patients with oral cavity cancer treated with surgery and adjuvant (chemo)radiotherapy but not in those treated with surgery alone. Somatic mutation of NFE2L2 led to Nrf2 activation and radioresistance in HNSCC cells. Tumors harboring mutant Nrf2E79Q were substantially more radioresistant than tumors with wild-type Nrf2 in immunocompetent mice, whereas the difference was diminished in immunocompromised mice. Nrf2E79Q enhanced radioresistance through increased recruitment of intratumoral polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and reduction of M1-polarized macrophages. Treatment with the glutaminase inhibitor CB-839 overcame the radioresistance induced by Nrf2E79Q or Nrf2E79K. RT increased expression of PMN-MDSC-attracting chemokines, including CXCL1, CXLC3, and CSF3, in Nrf2E79Q-expressing tumors via the TLR4, which could be reversed by CB-839. This study provides insights into the impact of NFE2L2 mutations on radioresistance and suggests that CB-839 can increase radiosensitivity by switching intratumoral myeloid cells to an antitumor phenotype, supporting clinical testing of CB-839 with RT in HNSCC with NFE2L2 mutations., Significance: NFE2L2 mutations are predictive biomarkers of radioresistance in head and neck cancer and confer sensitivity to glutaminase inhibitors to overcome radioresistance., (©2023 American Association for Cancer Research.)

Published
2023
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