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Introduction: Nipple-sparing mastectomy (NSM) is the latest advancement in the treatment of breast cancer. Long-term oncologic outcomes in nipple-sparing mastectomy (NSM) continue to be defined. Rates of locoregional recurrence for skin-sparing mastectomy (SSM) and NSM in the literature range from 0 to 14.3%. We investigated the outcomes of NSM at our institution. Methods: Patients undergoing NSM at our institution from 2006 to 2014 were identified. Patient demographics, tumor characteristics, and outcomes were collected. Locoregional recurrence was compared to previously published NSM and SSM results compiled from 14 and 11 studies in the literature. Institutional review board approval was obtained prior to the initiation of this study. Results: From 2006 to 2014, 319 patients (555 breasts) underwent NSM. 149 patients (248 breasts) had long-term follow-up available. Average patient age and BMI were 47.4 and 24.28. Eighty-five percent of patients underwent mastectomy primarily for a therapeutic indication. Average tumor size was 1.41 centimeters with the most common histologic type being invasive ductal carcinoma (66.7%) followed by DCIS (23.8%). Nodal disease was present in 14.8% of patients. Average patient follow-up was 30.72 months. There was one (0.7%) incidence of ipsilateral chest-wall recurrence in a 44 year-old (p Patient Demographics and Tumor CharacteristicsAge (years)47.7RaceCaucasian: 127 (85.2%) Non-Caucasian: 22 (14.8%)BMI24.28Tobacco History7 (4.7%)Radiation History8 (5.4%)BRCA 1/2 Status10 (6.7%)Family History38 (25.5%)Unilateral vs. Bilateral NSMUnilateral: 76 (51.0%) Bilateral: 73 (49.0%)Indication for MastectomyTherapeutic: 126 (84.6%) Prophylactic: 23 (15.4%)Neoadjuvant Therapy6 (4.0%)Follow-Up (months) (Range)30.72 (57.6-8.28)Tumor Size (cm)1.41Histologic Type (Percent of Therapeutic NSM)IDC: 82 (66.7%) DCIS: 30 (23.8%) ILC: 7 (5.6%) Invasive Other: 6 (4.8%) Mixed Type: 1 (0.8%)Pathologic StageStage 0: 52 (34.9%) Stage I: 54 (36.2%) Stage IIA: 14 (9.4%) Stage IIB: 8 (5.4%) Stage IIIA: 3 (2.0%) Stage IIIC: 1 (0.7%)Receptor StatusER (+): 90 (60.4%) PR (+): 79 (53.0%) Her 2/neu (+): 6 (4.0%) Ki-67 (High): 35 (23.5%)Positive Nodal Status22 (14.8%) NSM Complications per Patient22 (14.8%)Frozen Section: 6 (7 breasts) (4.0%) Permanent Section: 2 (1.3%)Mastectomy Flap Necrosis12 (8.1%)Nipple-Areola Complex NecrosisPartial-Thickness: 2 (1.3%) Full-Thickness: 1 (0.67%)Nipple-Areola Complex Excision (Patient Preference)1 (0.67%)Implant Extrusion4 (2.7%)CellulitisOral Antibiotics: 12 (8.1%) Intravenous Antibiotics: 2 (1.3%)Hematoma4 (2.7%)Seroma3 (2.0%)Wound Dehiscence1 (0.67%)Capsular Contracture2 (1.3%)Thoracodorsal Nerve Spasm1 (0.67%)Microvascular Free Flap Failure1 (0.67%) Conclusions: We examined our institutional outcomes with NSM and found a locoregional recurrence rate of 0.7% with no nipple-areolar complex recurrence. This rate is significantly lower than aggregate published rates for both NSM and SSM. Citation Format: Guth AA, Frey JD, Alperovich M, Kim JC, Axelrod DM, Shapiro RL, Choi M, Karp NS, Schnabel FR. Oncologic outcomes after nipple-sparing mastectomy: A single-institution experience. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-12-08.

Background: Nipple-sparing mastectomy (NSM) has gained popularity, but remains contoversial as the procedure's reconstructive outcomes and oncologic safety are still somewhat uncertain. Methods: We retrospectively reviewed the New York University-Langone Medical Center experience with NSM from 2006–2011. Outcomes measured include post-operative complications, breast cancer recurrence, presence of cancer at the nipple-areolar complex, and nipple-areolar complex viability. Results: Our data include patients who underwent NSM from 2006–2011. In total, the records of 235 (145 prophylactic, 90 theraputic) NSM at NYULMC were reviewed. Our reconstructive dta included all forms of reconstruction, including 144 tissue expanders, 74 microvascular free flaps, 16 immediate implants, and 1 combination latissimus dorsi flap with implant. Mean follow-up time was 19 months. No differences existed between the theraputic and prophylactic breast patients. The major complication rate of 4.3% (10/235) included 4 intraoperative hematoma evacuations, 1 flap anastomosis revision, and 3 explanted implants. One patient expired 4 months following surgery secondary to progression of disease. The microvascular free flap loss rate for this group was 0. Minor complications in 6.8% of patients consisted of implant exchange for asymmetry, operative revision of partial flap necrosis, intravenous antibiotics for infection, and 1 non-operative hematoma. In total, 5.9% of nipples were resected due to malignant or premalignant disease. There were 3 positive intraoperative biopsies with 9 additional biopsies positive on final pathology. To date, there have been no recurrences involving the nipple-areolar complex. The viability rate for the remaining nipples was 93.2% with1.7% of nipples undergoing complete necrosis, 3.8% partial necrosis, and 1.3% undergoing epiderolysis. Conclusions: This experience with NSM demonstrates the in a carefully selected cohort, oncologic safety and reconstructive outcome are comparable to the current standard of total mastectomy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-17-07.

Background: Advances in breast cancer screening and treatment have fostered the use of surgical procedures that increasingly optimize cosmetic outcome, while ensuring oncologic safety remains the primary concern of the oncologic surgeon. The role of nipple-sparing mastectomy (NSM) for risk-reducing surgery and breast cancer is evolving. It can be difficult to demonstrate involvement of the nipple-areolar complex (NAC) preoperatively, and and in this report we examine the utility of intraoperative subareolar frozen section (FS). Methods: Records of patients undergoing NSM at the NYU Langone Medical Center from 2006–2011 were reviewed retrospectively. Use of subareolar FS was at surgeon's discretion. Results: 237 NSM were performed (146 prophylacytic, 91 theraputic). FC was not utilized in 58 mastectomies (28 prophylactic), with 2 (+) on paraffin. Among the remaining 180 mastectomies, 11 biopsies were (+)(7.2%); 5 subareolar biopsies were (+) on FS and paraffin histologic slides (PS)(2.8%); 6 were negative on FS and (+) on PS. Among the 3 prophylactic NSM with (+) subareolar biopsies there was 1 (+) FS, 1 (−) FS, and 1 with no FS performed. There were no false (+) FS. Four of the 5 patients with (+)FS underwent simultaneous excision of the NAC. The 5th patient had atypia on FS and DCIS on PS, and returned to the OR during the same hospitalization for removal of NAC. The remaining patients underwent subsequent excision of the NAC either during planned 2nd stage reconstruction or following completion of chemotherapy. 8 NAC were free of disease and 5 were positive for in situ or invasive disease. There has been no local recurrence in these patients to date. Conclusions: The rate of NAC involvement is low, 5.5% in this series, and FS, while utilized in the majority of these cases, detected only 46% of subareolar disease. While FS can direct intraoperative decision making, the predictive power is low, and these considerations must be addressed in preoperative patient discussions. Furthermore, among those patients with (+) subareolar biopsies, only 39% had residual disease on NAC excision. Thus, optimal oncologic management of the NAC must still be considered an unresolved issue. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-14-03.

Purpose: Nipple and/or areola-sparing mastectomy as a therapeutic or prophylactic procedure for breast cancer is rapidly gaining popularity as the literature continues to support it safety. The lateral inframammary fold (IMF) approach provides adequate exposure and eliminates visible scars on the anterior surface of the breast, making this incision cosmetically superior to radial or periareolar approaches. Methods: We reviewed 58 consecutive nipple and/or areola-sparing mastectomies performed through a lateral IMF incision with immediate implant-based reconstruction, with or without tissue expansion, between June 2008 and February 2011. Prior to incision, breasts were lightly tumesced with dilute anesthetic solution with epinephrine. Sharp dissection, rather than electrocautery, was used as much as possible to minimize thermal injury to the mastectomy flap. When indicated, acellular dermal matrix was placed as an inferolateral sling. Subsequent fat grafting to correct contour deformities was performed in select patients. Three-dimensional (3D) photographs assessed changes in volume, antero-posterior projection, and ptosis. Retroareolar/nipple tissue underwent routine intraoperative frozen section analysis in cancer cases. Results: Mean patient age was 44 years, and mean follow-up time was 14 months. Depending upon the judgment of the oncologic surgeon, 44 (76%) mastectomies were nipple/areola-sparing, and 14 (24%) were areola-sparing. Thirteen mastectomies (22%) were therapeutic, the remaining 45 mastectomies (78%) were prophylactic. Five of the nine sentinel lymph node biopsies (56%) were performed through the lateral IMF incision without the need for a counter-incision. Acellular dermal matrix was used in 44 (76%) breasts. Average permanent implant volume was 313 cc (range 170 to 750 cc), and average fat grafting volume was 90 cc (range 36 to 177 cc). Mastectomy flap necrosis, requiring operative debridement, occurred in three breasts (5%). One of these breasts required a salvage latissimus dorsi myocutaneous flap to complete the reconstruction. Of the 44 nipple/areola sparing mastectomies, three (7%) required operative debridement and reconstruction for partial nipple necrosis. No statistically significant differences existed between therapeutic and prophylactic mastectomies for developing partial skin or nipple necrosis (p = 0.65). Morphologic outcomes using 3D scan measurements showed reconstructed breasts were larger, more projected, and less ptotic (196 vs. 248 cc, 80 vs. 90 mm, 146 vs. 134 mm, p < 0.01 for each parameter). Conclusion: Excellent results can be achieved with immediate implant-based reconstruction of nipple and/or areola-sparing mastectomy through a lateral IMF incision. NAC survival is reliable, and complication rates are low. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-16-09.

Abstract #4148 Introduction: Immediate breast reconstruction offers many advantages over staged techniques, including the psychological benefit of recovering from mastectomy with a reconstructed breast. In women with large breasts desiring immediate implant reconstruction, the challenge to the surgeon is to restore breast volume and provide adequate implant coverage. In the large-breasted woman desiring a large volume reconstruction a Wise-pattern skin resection provides good aesthetic results, however the submuscular implant pocket is inadequate to cover the inferior pole of the breast. In this patient population, the risk of implant exposure from T-point breakdown is significant. We present our technique of Wise-pattern breast reconstruction after skin-sparing mastectomy using alloderm and a vascularized dermal-subcutaneous pedicle to augment the volume and quality of implant coverage. Methods: A series of twenty patients have been reconstructed using the following technique. The selection criteria were women with large breasts who required an immediate implant reconstruction of ≥400cc volume. We employed a Wise-pattern design for resection of skin identical to that of a reduction mammaplasty. An inferiorly-based dermal-subcutaneous flap was developed. The T-point of the Wise pattern skin pattern was closed over this flap and provided vascularized coverage of the implant and alloderm at this vulnerable point. All patients underwent the standard skin-sparing mastectomy. The pectoralis major and seratus anterior muscles were released from their inferior and costal origins respectively, and as much alloderm as needed was sutured to these muscles to provide an adequate pocket for the desired implant volume. The dermal-subcutaneous pedicle was laid over the alloderm and sutured in place. The breast was then closed with the T-point overlying the dermal-subcutaneous pedicle. In unilateral reconstructions, a symmetrizing procedure using a Wise-pattern reduction mammaplasty was performed on the contralateral side. Results: The average volume of reconstruction in this study group was 458cc. Significant T-point breakdown occurred in 5 patients, and 3 of these would have had implant/alloderm exposure if the dermal pedicle were not present. These patients were treated with local wound care and healed with an excellent aesthetic result. None of these patients required implant removal, implant exchange or operative debridement. Conclusion: Wise-pattern skin-reducing mastectomy is an excellent strategy to provide an aesthetically pleasing, large immediate implant breast reconstruction. The reliability of this technique is significantly improved with the addition of alloderm to the muscular pocket and a vascularized dermal-subcutaneous pedicle to preserve the integrity of the reconstruction in the presence of T-point breakdown. This technique can be added to the armamentarium of the plastic surgeon to safely restore breast size in one stage, remove the morbidity of multiple operations, and provide patients with the psychological benefits of an immediate reconstruction. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4148.