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Your search keyword '"Magbanua, Mark Jesus M."' showing total 9 results
Start Over Author "Magbanua, Mark Jesus M." Journal cancer research
9 results on '"Magbanua, Mark Jesus M."'

1. Abstract A014: Cell-free DNA concentration as a biomarker of response and recurrence in HER-2 negative breast cancer receiving neoadjuvant chemotherapy

Author

Magbanua, Mark Jesus M., primary, Ahmed, Ziad, additional, Sayaman, Rosalyn W., additional, Brown-Swigart, Lamorna, additional, Hirst, Gillian L., additional, Yau, Christina, additional, Wolf, Denise M., additional, Li, Wen, additional, Delson, Amy L., additional, Perlmutter, Jane, additional, Symmans, W. Fraser, additional, Yee, Douglas, additional, Hylton, Nola M., additional, Esserman, Laura J., additional, DeMichele, Angela M., additional, Rugo, Hope S., additional, and van ’t Veer, Laura J., additional

Published
2024
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2. Abstract B077: Subtype-specific signaling dynamics during treatment in non-responding breast cancer patients in the neoadjuvant I-SPY2 TRIAL: are there clues on how to overcome resistance?

Author

Wolf, Denise M., primary, Yau, Christina, additional, Magbanua, Mark Jesus M., additional, Sayaman, Rosalyn, additional, Wulfkhule, Julia, additional, Gallagher, Rosa I., additional, Brown-Swigart, Lamorna, additional, Campbell, Michael J., additional, Basu, Amrita, additional, Hirst, Gillian L., additional, Perlmutter, Jane, additional, DeMichele, Angela, additional, Yee, Doug, additional, Pusztai, Lajos, additional, Pohlmann, Paula R., additional, Clark, Amy S., additional, Rugo, Hope S., additional, Petricoin, Emanuel F., additional, Esserman, Laura J., additional, and van ‘t Veer, Laura, additional

Published
2024
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3. Genomic Profiling of Isolated Circulating Tumor Cells from Metastatic Breast Cancer Patients

Author

Magbanua, Mark Jesus M, Sosa, Eduardo V, Roy, Ritu, Eisenbud, Lauren E, Scott, Janet H, Olshen, Adam, Pinkel, Dan, Rugo, Hope S, and Park, John W

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Human Genome, Breast Cancer, Cancer, Prevention, Biotechnology, Clinical Research, Breast Neoplasms, Cell Separation, Comparative Genomic Hybridization, Female, Flow Cytometry, Gene Dosage, Gene Expression Profiling, Humans, Neoplasm Metastasis, Neoplastic Cells, Circulating, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Molecular characterization of circulating tumor cells (CTC) from blood is technically challenging because cells are rare and difficult to isolate. We developed a novel approach to isolate CTCs from blood via immunomagnetic enrichment followed by fluorescence-activated cell sorting (IE-FACS). Isolated CTCs were subjected to genome-wide copy number analysis via array comparative genomic hybridization (aCGH). In clinical studies, CTCs were isolated from 181 patients with metastatic breast cancer, 102 of which were successfully profiled, including matched archival primary tumor from five patients. CTCs revealed a wide range of copy number alterations including those previously reported in breast cancer. Comparison with two published aCGH datasets of primary breast tumors revealed similar frequencies of recurrent genomic copy number aberrations. In addition, serial testing of CTCs confirmed reproducibility and indicated genomic change over time. Comparison of CTCs with matched archival primary tumors confirmed shared lineage as well as some divergence. We showed that it is feasible to isolate CTCs away from hematopoietic cells with high purity through IE-FACS and profile them via aCGH analysis. Our approach may be used to explore genomic events involved in cancer progression and to monitor therapeutic efficacy of targeted therapies in clinical trials in a relatively noninvasive manner.

Published
2013

4. Abstract PD5-04: PD5-04 Characterizing the HER2-/Immune-/DNA repair (DRD-) response predictive breast cancer subtype: the hunt for new protein targets in a high-needs population with low response to all I-SPY2 agents

Author

Wolf, Denise M., primary, Yau, Christina, additional, Wulfkuhle, Julia, additional, Gallagher, Rosa I., additional, Swigart, Lamorna A. Brown, additional, Hirst, Gillian L., additional, Coppe, Jean-Philippe, additional, Magbanua, Mark Jesus M., additional, Sayaman, Rosalyn, additional, Investigators, I-SPY2, additional, Sit, Laura, additional, Hylton, Nola M., additional, DeMichele, Angela, additional, Berry, Donald A., additional, Pusztai, Lajos, additional, Yee, Douglas, additional, Esserman, Laura J., additional, Petricoin, Emanuel F., additional, and Van ’t Veer, Laura, additional

Published
2023
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5. Abstract P5-05-05: Monitoring for response and recurrence in neoadjuvant-treated hormone receptor-positive HER2-negative breast cancer by personalized circulating tumor DNA testing

Author

Magbanua, Mark Jesus M., primary, Rugo, Hope, additional, Swigart, Lamorna A. Brown, additional, Ahmed, Ziad, additional, Hirst, Gillian L., additional, Wolf, Denise M., additional, Lu, Ruixiao, additional, Kalashnikova, Ekaterina, additional, Renner, Derrick, additional, Rodriguez, Angel, additional, Liu, Minetta C., additional, Yau, Christina, additional, Esserman, Laura J., additional, Van ’t Veer, Laura, additional, and DeMichele, Angela, additional

Published
2023
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6. Abstract PS2-07: Outcomes associated with disseminated tumor cells at surgery after neoadjuvant chemotherapy in high-risk early stage breast cancer: The I-SPY SURMOUNT study

Author

Magbanua, Mark Jesus M, primary, van 't Veer, Laura, additional, Clark, Amy, additional, Chien, A. Jo, additional, Boughey, Judy, additional, Han, Heather, additional, Wallace, Anne, additional, Beckwith, Heather, additional, Liu, Minetta, additional, Yau, Christina, additional, Wileyto, E. Paul, additional, Swigart, Lamorna Brown, additional, Perlmutter, Jane, additional, Bayne, Lauren, additional, Deluca, Shannon, additional, Yee, Stephanie, additional, Carpenter, Erica, additional, Esserman, Laura, additional, Park, John, additional, Chodosh, Lewis, additional, and DeMichele, Angela, additional

Published
2021
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7. Abstract PS2-19: Circulating tumor cell (CTC) enumeration in a phase II trial of pazopanib in addition to endocrine therapy in patients with hormone resistant advanced breast cancer (ABC)

Author

Gumusay, Ozge, primary, Magbanua, Mark Jesus M., additional, Majure, Melanie C., additional, Deal, Travis, additional, Renslo, Jonathan R., additional, Wabl, Chiara A., additional, Melisko, Michelle E., additional, Chien, A. Jo, additional, Goga, Andrei, additional, Moasser, Mark M., additional, Park, John W., additional, Hwang, Jimmy, additional, and Rugo, Hope S., additional

Published
2021
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8. Quantitative Whole Genome Sequencing of Circulating Tumor Cells Enables Personalized Combination Therapy of Metastatic Cancer

Author

Gulbahce, Natali, primary, Magbanua, Mark Jesus M., additional, Chin, Robert, additional, Agarwal, Misha R., additional, Luo, Xuhao, additional, Liu, Jia, additional, Hayden, Daniel M., additional, Mao, Qing, additional, Ciotlos, Serban, additional, Li, Zhenyu, additional, Chen, Yanxiang, additional, Chen, Xingpeng, additional, Li, Yuxiang, additional, Zhang, Rebecca Yu, additional, Lee, Katharine, additional, Tearle, Rick, additional, Park, Emily, additional, Drmanac, Snezana, additional, Rugo, Hope S., additional, Park, John W., additional, Drmanac, Radoje, additional, and Peters, Brock A., additional

Published
2017
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9. Molecular Profiling of Tumor Cells in Cerebrospinal Fluid and Matched Primary Tumors from Metastatic Breast Cancer Patients with Leptomeningeal Carcinomatosis

Author

Magbanua, Mark Jesus M., primary, Melisko, Michelle, additional, Roy, Ritu, additional, Sosa, Eduardo V., additional, Hauranieh, Louai, additional, Kablanian, Andrea, additional, Eisenbud, Lauren E., additional, Ryazantsev, Artem, additional, Au, Alfred, additional, Scott, Janet H., additional, and Park, John W., additional

Published
2013
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