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Your search keyword '"Iyengar, Neil M"' showing total 8 results
Start Over Author "Iyengar, Neil M" Journal cancer research
8 results on '"Iyengar, Neil M"'

2. Abstract P5-08-07: Dietary patterns among women with early-stage breast cancer from the Healthy Living Program

Author

Liu, Bethina, primary, Shen, Sherry, additional, Salehi, Erica, additional, Chen, Yuan, additional, Toumbacaris, Nicolas, additional, Allsop, Johnny, additional, Anselmo, Cara, additional, Corcoran, Stacie, additional, Kelly, Bridget, additional, Magnoli, Rocco, additional, Smith, Andrea, additional, Emerzian, Melissa, additional, Brockway-Marchello, Julia, additional, Bacotti, Doreen, additional, Robson, Mark E., additional, and Iyengar, Neil M., additional

Published
2023
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3. Abstract P2-06-03: Obesity is associated with DNA damage in the breast epithelium of BRCA1 and BRCA2 mutation carriers: A role for estrogens & strategies for prevention

Author

Bhardwaj, Priya, primary, Iyengar, Neil M., additional, Oshchepkova, Sofya, additional, Piloco, Phoebe, additional, Bareja, Rohan, additional, Elemento, Olivier, additional, Giri, Dilip D., additional, Pollak, Michael, additional, Morrow, Monica, additional, Spector, Jason A., additional, and Brown, Kristy A., additional

Published
2022
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4. Abstract P1-14-03: Adjuvant enzalutamide for the treatment of early-stage androgen-receptor positive, triple negative breast cancer: A feasibility study

Author

Walsh, Elaine M, primary, Gucalp, Ayca, additional, Patil, Sujata, additional, Edelweiss, Marcia, additional, Ross, Dara S, additional, Razavi, Pedram, additional, Modi, Shanu, additional, Iyengar, Neil M, additional, Sanford, Rachel, additional, Troso-Sandoval, Tiffany, additional, Gorsky, Mila, additional, Bromberg, Jackie, additional, Drullinsky, Pamela, additional, Lake, Diana, additional, Wong, Serena, additional, DeFusco, Patricia, additional, Lamparella, Nicholas, additional, Gupta, Ranja, additional, Tabassum, Tasmila, additional, Boyle, Leigh Ann, additional, Arumov, Artavazd, additional, and Traina, Tiffany A, additional

Published
2022
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5. Abstract P2-08-05: Plasma lipidomics analysis to identify potential non-invasive biomarkers for breast white adipose inflammation and aromatase expression levels

Author

Cai, Xiao, primary, Wei, Siqi, additional, Xu, Zizhuo, additional, Zhou, Xi K, additional, Peck, Andrew, additional, Lai, Steven, additional, Isaac, Giorgis, additional, Olivos, Hernando, additional, Munjoma, Nayasha, additional, Dhungana, Suraj, additional, Plumb, Rob, additional, Dannenberg, Andrew J, additional, and Iyengar, Neil M, additional

Published
2022
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6. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs

Author

Mattox, Austin K., primary, Lee, Jina, additional, Westra, William H., additional, Pierce, Robert H., additional, Ghossein, Ronald, additional, Faquin, William C., additional, Diefenbach, Thomas J., additional, Morris, Luc G., additional, Lin, Derrick T., additional, Wirth, Lori J., additional, Lefranc-Torres, Armida, additional, Ishida, Eiichi, additional, Chakravarty, Patrick D., additional, Johnson, Lauren, additional, Zeng, Yang C., additional, Chen, Huabiao, additional, Poznansky, Mark C., additional, Iyengar, Neil M., additional, and Pai, Sara I., additional

Published
2017
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7. Abstract 4509: Clinical genomic profiling of 1000 metastatic breast cancer patients: actionable targets, novel alterations, and clinical correlations

Author

Razavi, Pedram, primary, Chang, Matthew T., additional, Middha, Sumit, additional, Ross, Dara S., additional, Zehir, Ahmet, additional, Proverbs-Singh, Tracy A., additional, Kandoth, Cyriac, additional, Chandarlapaty, Sarat, additional, Dickler, Maura N., additional, Reis-Filho, Jorge S., additional, Patil, Sujata, additional, Seshan, Venkatraman, additional, Smyth, Lillian, additional, Iyengar, Neil M., additional, Jhaveri, Komal, additional, Modi, Shanu, additional, Dang, Chau T., additional, Robson, Mark E., additional, Norton, Larry, additional, Hudis, Clifford A., additional, Ladanyi, Marc, additional, Scaltriti, Maurizio, additional, Schultz, Nikolaus, additional, Hyman, David, additional, Berger, Michael F., additional, Taylor, Barry S., additional, Solit, David B., additional, and Baselga., José, additional

Published
2016
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8. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4 + TILs in the Presence of PD-L1 + TAMs.

Author

Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, and Pai SI

Subjects
CD4-Positive T-Lymphocytes immunology, CD4-Positive T-Lymphocytes metabolism, CD8-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes metabolism, Carcinoma, Squamous Cell immunology, Carcinoma, Squamous Cell pathology, Clonal Anergy immunology, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphocytes, Tumor-Infiltrating immunology, Macrophages immunology, Microscopy, Fluorescence, Mouth Neoplasms immunology, Mouth Neoplasms pathology, Tumor Microenvironment immunology, B7-H1 Antigen biosynthesis, Carcinoma, Squamous Cell metabolism, Lymphocytes, Tumor-Infiltrating metabolism, Macrophages metabolism, Mouth Neoplasms metabolism, Programmed Cell Death 1 Receptor biosynthesis
Abstract

Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cavity tumor. In this study, we examined the basis for the activity of programmed cell death protein (PD-1)-based immune checkpoint therapy that is being explored widely in head and neck cancers. Using multispectral imaging, we systematically investigated the OTSCC tumor microenvironment (TME) by evaluating the frequency of PD-1 expression in CD8 + , CD4 + , and FoxP3 + tumor-infiltrating lymphocytes (TIL). We also defined the cellular sources of PD-1 ligand (PD-L1) to evaluate the utility of PD-1:PD-L1 blocking antibody therapy in this patient population. PD-L1 was expressed in 79% of the OTSCC specimens examined within the TME. Expression of PD-L1 was associated with moderate to high levels of CD4 + and CD8 + TILs. We found that CD4 + TILs were present in equal or greater frequencies than CD8 + TILs in 94% of OTSCC and that CD4 + FOXP3neg TILs were colocalized with PD-1/PD-L1/CD68 more frequently than CD8 + TILs. Both CD4 + PD1 + and CD8 + PD1 + TILs were anergic in the setting of PD-L1 expression. Overall, our results highlight the importance of CD4 + TILs as pivotal regulators of PD-L1 levels and in determining the responsiveness of OTSCC to PD1-based immune checkpoint therapy. Cancer Res; 77(22); 6365-74. ©2017 AACR ., (©2017 American Association for Cancer Research.)

Published
2017
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