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Your search keyword '"Haegert, Anne"' showing total 5 results
Start Over Author "Haegert, Anne" Journal cancer research
5 results on '"Haegert, Anne"'

1. Multiomics Characterization of Low-Grade Serous Ovarian Carcinoma Identifies Potential Biomarkers of MEK Inhibitor Sensitivity and Therapeutic Vulnerability

Author

Shrestha, Raunak, primary, Llaurado Fernandez, Marta, additional, Dawson, Amy, additional, Hoenisch, Joshua, additional, Volik, Stanislav, additional, Lin, Yen-Yi, additional, Anderson, Shawn, additional, Kim, Hannah, additional, Haegert, Anne M., additional, Colborne, Shane, additional, Wong, Nelson K.Y., additional, McConeghy, Brian, additional, Bell, Robert H., additional, Brahmbhatt, Sonal, additional, Lee, Cheng-Han, additional, DiMattia, Gabriel E., additional, Le Bihan, Stephane, additional, Morin, Gregg B., additional, Collins, Colin C., additional, and Carey, Mark S., additional

Published
2021
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2. Heterochromatin Protein 1α Mediates Development and Aggressiveness of Neuroendocrine Prostate Cancer

Author

Ci, Xinpei, primary, Hao, Jun, additional, Dong, Xin, additional, Choi, Stephen Y., additional, Xue, Hui, additional, Wu, Rebecca, additional, Qu, Sifeng, additional, Gout, Peter W., additional, Zhang, Fang, additional, Haegert, Anne M., additional, Fazli, Ladan, additional, Crea, Francesco, additional, Ong, Christopher J., additional, Zoubeidi, Amina, additional, He, Housheng H., additional, Gleave, Martin E., additional, Collins, Colin C., additional, Lin, Dong, additional, and Wang, Yuzhuo, additional

Published
2018
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3. High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

Author

Lin, Dong, primary, Wyatt, Alexander W., additional, Xue, Hui, additional, Wang, Yuwei, additional, Dong, Xin, additional, Haegert, Anne, additional, Wu, Rebecca, additional, Brahmbhatt, Sonal, additional, Mo, Fan, additional, Jong, Lina, additional, Bell, Robert H., additional, Anderson, Shawn, additional, Hurtado-Coll, Antonio, additional, Fazli, Ladan, additional, Sharma, Manju, additional, Beltran, Himisha, additional, Rubin, Mark, additional, Cox, Michael, additional, Gout, Peter W., additional, Morris, James, additional, Goldenberg, Larry, additional, Volik, Stanislav V., additional, Gleave, Martin E., additional, Collins, Colin C., additional, and Wang, Yuzhuo, additional

Published
2014
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5. High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development.

Author

Dong Lin, Wyatt, Alexander W., Hui Xue, Yuwei Wang, Xin Dong, Haegert, Anne, Wu, Rebecca, Brahmbhatt, Sonal, Fan Mo, Lina Jong, Bell, Robert H., Anderson, Shawn, Hurtado-Coll, Antonio, Fazli, Ladan, Sharma, Manju, Beltran, Himisha, Rubin, Mark, Cox, Michael, Gout, Peter W., and Morris, James

Subjects
*PROSTATE cancer, *XENOTRANSPLANTATION, *HISTOPATHOLOGY, *NEEDLE biopsy, *ADENOCARCINOMA, *CANCER invasiveness, *CANCER treatment
Abstract

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development. Xenografts preserved the histopathology, genome architecture, and global gene expression of donor tumors. Moreover, their aggressiveness matched patient observations, and their response to androgen withdrawal correlated with tumor subtype. The panel includes the first xenografts generated from needle biopsy tissue obtained at diagnosis. This advance was exploited to generate independent xenografts from different sites of a primary site, enabling functional dissection of tumor heterogeneity. Prolonged exposure of adenocarcinoma xenografts to androgen withdrawal led to castration-resistant prostate cancer, including the first-in-field model of complete transdifferentiation into lethal neuroendocrine prostate cancer. Further analysis of this model supports the hypothesis that neuroendocrine prostate cancer can evolve directly from adenocarcinoma via an adaptive response and yielded a set of genes potentially involved in neuroendocrine transdifferentiation. We predict that these next-generation models will be transformative for advancing mechanistic understanding of disease progression, response to therapy, and personalized oncology. [ABSTRACT FROM AUTHOR]

Published
2014
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