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Your search keyword '"Gilbertson, Richard J"' showing total 24 results
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24 results on '"Gilbertson, Richard J"'

1. Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma

Author

Wang, Jun, primary, Merino, Diana M., additional, Light, Nicholas, additional, Murphy, Brian L., additional, Wang, Yong-Dong, additional, Guo, Xiaohui, additional, Hodges, Andrew P., additional, Chau, Lianne Q., additional, Liu, Kun-Wei, additional, Dhall, Girish, additional, Asgharzadeh, Shahab, additional, Kiehna, Erin N., additional, Shirey, Ryan J., additional, Janda, Kim D., additional, Taylor, Michael D., additional, Malkin, David, additional, Ellison, David W., additional, VandenBerg, Scott R., additional, Eberhart, Charles G., additional, Sears, Rosalie C., additional, Roussel, Martine F., additional, Gilbertson, Richard J., additional, and Wechsler-Reya, Robert J., additional

Published
2019
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6. Abstract 3111: Identification of genes that frequently exhibit copy number alterations in pediatric ependymomas

Author

Hamm, Christopher A., primary, Costa, Fabricio F., additional, Bischof, Jared M., additional, Vanin, Elio F., additional, Bonaldo, Maria de Fatima, additional, Iannaccone, Steve, additional, Rajaram, Veena, additional, George, David, additional, Tomita, Tadanori, additional, Goldman, Stewart, additional, Jennings, Lawrence J., additional, Gilbertson, Richard J., additional, and Soares, Marcelo B., additional

Published
2014
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17. Abstract 4759: Integrated in vitro and in vivo screening of tumor and normal neural stem cells identifies potential new treatments of ependymoma

Author

Atkinson, Jennifer M., primary, Shelat, Anang A., additional, Kranenburg, Tanya A., additional, Carcaboso, Angel M., additional, Arnold, Alexander, additional, Wright, Karen D., additional, Johnson, Robert A., additional, Poppleton, Helen, additional, Mohankumar, Kumarasamypet M., additional, Gibson, Paul, additional, Phoenix, Timothy N., additional, Zhu, Liqin, additional, Tong, Yiai, additional, Eden, Christopher, additional, Gajjar, Amar, additional, Stewart, Clinton F., additional, Guy, R.Kip, additional, and Gilbertson, Richard J., additional

Published
2011
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18. Abstract 3448: Subtypes of medulloblastoma have distinct developmental origins

Author

Gibson, Paul, primary, Tong, Yiai, additional, Robinson, Giles, additional, Poppleton, Helen, additional, Thompson, Margaret C., additional, Currle, David S., additional, Eden, Christopher, additional, Hogg, Twala L., additional, Finkelstein, David, additional, Pounds, Stanley, additional, Patay, Zoltan, additional, Scoggins, Matthew, additional, Pei, Yanxin, additional, Ogg, Robert, additional, Lee, Youngsoo, additional, Zindy, Frederique, additional, Lindsey, Janet C., additional, Boop, Frederic A., additional, Gajjar, Amar, additional, Clifford, Steven C., additional, Roussel, Martine F., additional, McKinnon, Peter J., additional, Ellison, David W., additional, Wechsler-Reya, Robert, additional, Gutmann, David H., additional, and Gilbertson, Richard J., additional

Published
2011
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21. Regression of Experimental Medulloblastoma following Transfer of HER2-Specific T Cells

Author

Ahmed, Nabil, primary, Ratnayake, Maheshika, additional, Savoldo, Barbara, additional, Perlaky, Laszlo, additional, Dotti, Gianpietro, additional, Wels, Winfried S., additional, Bhattacharjee, Meenakshi B., additional, Gilbertson, Richard J., additional, Shine, H. David, additional, Weiss, Heidi L., additional, Rooney, Cliona M., additional, Heslop, Helen E., additional, and Gottschalk, Stephen, additional

Published
2007
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23. A molecular fingerprint for medulloblastoma.

Author

Lee Y, Miller HL, Jensen P, Hernan R, Connelly M, Wetmore C, Zindy F, Roussel MF, Curran T, Gilbertson RJ, and McKinnon PJ

Subjects
Animals, Cell Division genetics, Cerebellar Neoplasms metabolism, Child, Preschool, Cytoplasmic Granules genetics, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Humans, Medulloblastoma metabolism, Mice, Up-Regulation, Cerebellar Neoplasms genetics, Medulloblastoma genetics
Abstract

Medulloblastoma is the most common malignant pediatric brain tumor. In mice, Ptc1 haploinsufficiency and disruption of DNA repair (DNA ligase IV inactivation) or cell cycle regulation (Kip1, Ink4d, or Ink4c inactivation), in conjunction with p53 dysfunction, predispose to medulloblastoma. To identify genes important for this tumor, we evaluated gene expression profiles in medulloblastomas from these mice. Unexpectedly, medulloblastoma expression profiles were very similar among tumors and also to those of developing cerebellum. However, 21 genes were specifically up-regulated in medulloblastoma, including sFrp1, Ptc2, and Math1, members of signaling pathways that regulate cerebellar development. Coordinated deregulation of these same genes also occurred in a large subset of human medulloblastomas. These data identify a group of genes that is central to medulloblastoma tumorigenesis.

Published
2003

24. ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.

Author

Hernan R, Fasheh R, Calabrese C, Frank AJ, Maclean KH, Allard D, Barraclough R, and Gilbertson RJ

Subjects
Animals, Brain Stem Neoplasms pathology, Child, Genes, Reporter, Humans, Luciferases genetics, Medulloblastoma pathology, Mice, Mice, Nude, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Plasmids, Recombinant Proteins metabolism, S100 Calcium-Binding Protein A4, Transfection, Transplantation, Heterologous, Tumor Cells, Cultured, Brain Stem Neoplasms genetics, Gene Expression Regulation, Neoplastic, Genes, erbB-2, Medulloblastoma genetics, Neoplasm Metastasis genetics, Neoplasm Metastasis pathology, Receptor, ErbB-2 genetics, S100 Proteins genetics
Abstract

Medulloblastoma is frequently disseminated throughout the central nervous system by the time of diagnosis. Conventional therapeutic approaches have not reduced the high mortality associated with metastatic medulloblastoma and little is known regarding the molecular mechanisms that promote tumor invasion. Previously, we reported that overexpression of ERBB2 in medulloblastoma is associated with poor prognosis and metastasis. Here, we demonstrate that ERBB2 overexpression increases the migration of medulloblastoma cells across basement membranes in vitro. Furthermore, using microarray expression profiling, we show that ERBB2 up-regulates the expression of prometastatic genes in medulloblastoma cells. These include S100A4, which was previously shown to promote metastasis of breast cancer. We demonstrate that S100A4 is a direct target of ERBB2 signaling in medulloblastoma cells via a pathway involving phosphatidylinositol 3-kinase, AKT1, and extracellular signal-regulated kinase 1/2 and that levels of ERBB2 and S100A4 are tightly correlated in samples of primary medulloblastoma. Finally, we show that ERBB2-dependent medulloblastoma cell invasion in vitro and prometastatic gene expression in vivo can be blocked using the ERBB tyrosine kinase inhibitor OSI-774. These data identify an ERBB2 driven prometastatic pathway that may provide a novel target for therapeutic intervention in metastatic medulloblastoma.

Published
2003

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