25 results on '"Eccles, Suzanne A"'
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2. Abstract 1651: In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346
3. Abstract 129: Assessing the mechanism and therapeutic potential of modulators of the human mediator complex-associated protein kinases CDK8 and CDK19
4. Abstract 4355: Elucidation of the different roles of CDK8 and CDK19 in colorectal cancer (CRC) using CRISPR gene editing technology
5. Abstract 3271: Novel orthotopic pediatric high grade glioma xenografts evaluated with magnetic resonance imaging mimic human disease
6. Exploring the Biomechanical Properties of Brain Malignancies and Their Pathologic Determinants In Vivo with Magnetic Resonance Elastography
7. Abstract 2433: In vitro and in vivo antitumor activity of the next generation HSP90 inhibitor, AT13387, in both hormone-sensitive and castration-resistant prostate cancer models.
8. Abstract 3924: Multimodality imaging investigation of response to cabozantinib in a VCaP model of prostate bone metastasis.
9. Abstract 1559: Evaluation of MR imaging biomarkers of the vascular and infiltrative phenotype in intracranial MDA-MB-231 tumors.
10. Abstract 4459: Evaluating imaging biomarkers of acquired resistance to targeted EGFR therapy in xenograft models of human squamous cell carcinoma of the head and neck (SCCHN).
11. Abstract 3242: CCT271850, a novel, selective, highly potent and orally bioavailable Mps1 kinase inhibitor.
12. Abstract 1817: Characterisation of CCT251455, a novel, selective and highly potent Mps1 kinase inhibitor
13. Abstract 463: MAP4K4 (HGK) plays a key role in tumor progression
14. Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors
15. Abstract 3554: CCT137690, a dual inhibitor of Aurora and FLT3 kinases, sensitizes FLT3-ITD positive acute myeloid leukemia and overcomes resistance to selective FLT3-inhibition
16. Abstract 4277: High throughput 3D tumor spheroid assays for target validation and drug evaluation
17. Abstract 694: Immunohistochemical discrimination of wild type EGFR from EGFRvIII in fixed tumor specimens using anti-EGFR mAbs ICR9 and ICR10
18. Abstract 1932: Targeting the extended erbb receptor family using chimeric antigen receptor (CAR)-grafted t-cells as a treatment for head and neck cancer
19. Abstract LB-58: Angiogenic signaling is upregulated in human oral squamous carcinoma cells with acquired resistance to the EGFR inhibitor gefitinib
20. Acquired Resistance to 17-Allylamino-17-Demethoxygeldanamycin (17-AAG, Tanespimycin) in Glioblastoma Cells
21. CHR-2797: An Antiproliferative Aminopeptidase Inhibitor that Leads to Amino Acid Deprivation in Human Leukemic Cells
22. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
23. Syk Tyrosine Kinase Is Linked to Cell Motility and Progression in Squamous Cell Carcinomas of the Head and Neck
24. Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
25. Small Molecule Antagonists of the σ-1 Receptor Cause Selective Release of the Death Program in Tumor and Self-Reliant Cells and Inhibit Tumor Growthin Vitroandin Vivo
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