Search

Your search keyword '"Durcan, L"' showing total 4 results
Start Over Author "Durcan, L" Journal cancer research
4 results on '"Durcan, L"'

3. A Novel Tumour-Based Test To Identify Breast Cancer Due to BRCA1 and BRCA2 Mutations.

Author

Eccles, D., primary, An, Q., additional, Jones, L., additional, Tapper, W., additional, Chelala, C., additional, Iravani, M., additional, McKay, A., additional, Hammond, V., additional, Durcan, L., additional, Gerty, S., additional, Strefford, J., additional, Ferguson, A., additional, Peock, S., additional, Reis-Filho, J., additional, Easton, D., additional, and Ashworth, A., additional

Published
2009
Full Text
View/download PDF

4. Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

Author

Stevens KN, Vachon CM, Lee AM, Slager S, Lesnick T, Olswold C, Fasching PA, Miron P, Eccles D, Carpenter JE, Godwin AK, Ambrosone C, Winqvist R, Brauch H, Schmidt MK, Cox A, Cross SS, Sawyer E, Hartmann A, Beckmann MW, Schulz-Wendtland R, Ekici AB, Tapper WJ, Gerty SM, Durcan L, Graham N, Hein R, Nickels S, Flesch-Janys D, Heinz J, Sinn HP, Konstantopoulou I, Fostira F, Pectasides D, Dimopoulos AM, Fountzilas G, Clarke CL, Balleine R, Olson JE, Fredericksen Z, Diasio RB, Pathak H, Ross E, Weaver J, Rüdiger T, Försti A, Dünnebier T, Ademuyiwa F, Kulkarni S, Pylkäs K, Jukkola-Vuorinen A, Ko YD, Van Limbergen E, Janssen H, Peto J, Fletcher O, Giles GG, Baglietto L, Verhoef S, Tomlinson I, Kosma VM, Beesley J, Greco D, Blomqvist C, Irwanto A, Liu J, Blows FM, Dawson SJ, Margolin S, Mannermaa A, Martin NG, Montgomery GW, Lambrechts D, dos Santos Silva I, Severi G, Hamann U, Pharoah P, Easton DF, Chang-Claude J, Yannoukakos D, Nevanlinna H, Wang X, and Couch FJ

Subjects
Adult, Aged, Breast Neoplasms etiology, Breast Neoplasms metabolism, Case-Control Studies, Chromosomes, Human, Pair 19 genetics, Female, Humans, Middle Aged, Receptors, Estrogen metabolism, Receptors, Progesterone metabolism, Risk, White People, Young Adult, Breast Neoplasms genetics, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Receptors, Estrogen genetics, Receptors, Progesterone genetics
Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results