Search

Your search keyword '"Cowley, Mark J"' showing total 7 results
Start Over Author "Cowley, Mark J" Journal cancer research
7 results on '"Cowley, Mark J"'

1. High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer

Author

Mayoh, Chelsea, primary, Mao, Jie, additional, Xie, Jinhan, additional, Tax, Gabor, additional, Chow, Shu-Oi, additional, Cadiz, Roxanne, additional, Pazaky, Karina, additional, Barahona, Paulette, additional, Ajuyah, Pamela, additional, Trebilcock, Peter, additional, Malquori, Angela, additional, Gunther, Kate, additional, Avila, Anica, additional, Yun, Doo Young, additional, Alfred, Stephanie, additional, Gopalakrishnan, Anjana, additional, Kamili, Alvin, additional, Wong, Marie, additional, Cowley, Mark J., additional, Jessop, Sophie, additional, Lau, Loretta M.S., additional, Trahair, Toby N., additional, Ziegler, David S., additional, Fletcher, Jamie I., additional, Gifford, Andrew J., additional, Tsoli, Maria, additional, Marshall, Glenn M., additional, Haber, Michelle, additional, Tyrrell, Vanessa, additional, Failes, Timothy W., additional, Arndt, Greg M., additional, Lock, Richard B., additional, Ekert, Paul G., additional, and Dolman, M. Emmy M., additional

Published
2023
Full Text
View/download PDF

2. Abstract LB-137: Integrated genomics: drug screening and personalized xenograft development approach to identify precision treatments for aggressive pediatric brain tumors

Author

Tsoli, Maria, primary, Wadham, Carol, additional, Pinese, Mark, additional, Failes, Tim, additional, Joshi, Swapna, additional, Mould, Emily, additional, Yin, Julia, additional, Gayevski, Velimir, additional, Kumar, Amit, additional, Kaplan, Warren, additional, Ekert, Paul, additional, Franshaw, Laura, additional, Gifford, Andrew, additional, Weber, Martin, additional, Rodriguez, Michael, additional, Mayoh, Chelsea, additional, Cohn, Richard, additional, Arndt, Greg, additional, Lock, Richard, additional, Tyrrell, Vanessa, additional, Norris, Murray, additional, Haber, Michelle, additional, Lau, Loretta, additional, Quang, Dong Anh Khuong, additional, Wong, Marie, additional, Trahair, Toby, additional, Marshall, Glenn M., additional, Cowley, Mark J., additional, and Ziegler, David S., additional

Published
2018
Full Text
View/download PDF

4. Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial α5 Integrin

Author

Cao, Ying, primary, Hoeppner, Luke H., additional, Bach, Steven, additional, E, Guangqi, additional, Guo, Yan, additional, Wang, Enfeng, additional, Wu, Jianmin, additional, Cowley, Mark J., additional, Chang, David K., additional, Waddell, Nicola, additional, Grimmond, Sean M., additional, Biankin, Andrew V., additional, Daly, Roger J., additional, Zhang, Xiaohui, additional, and Mukhopadhyay, Debabrata, additional

Published
2013
Full Text
View/download PDF

5. Abstract 1156: A molecular pre-operative prognostic nomogram for resectable pancreatic cancer.

Author

Chang, David K., primary, Pinese, Mark, additional, Scarlett, Christopher J., additional, Pajic, Marina, additional, Colvin, Emily K., additional, Johns, Amber L., additional, Wu, Jianmin, additional, Cowley, Mark J., additional, Humphris, Jeremy L., additional, Chou, Angela, additional, Nguyen, Nam Q., additional, Nagrial, Adnan M., additional, Chantrill, Lorraine, additional, Chin, Venessa T., additional, Musgrove, Elizabeth A., additional, Altekruse, Sean, additional, Gill, Anthony J., additional, Kench, James G., additional, and Biankin, Andrew V., additional

Published
2013
Full Text
View/download PDF

6. Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer

Author

Wauters, Elke, primary, Sanchez-Arévalo Lobo, Victor J., additional, Pinho, Andreia V., additional, Mawson, Amanda, additional, Herranz, Daniel, additional, Wu, Jianmin, additional, Cowley, Mark J., additional, Colvin, Emily K., additional, Njicop, Erna Ngwayi, additional, Sutherland, Rob L., additional, Liu, Tao, additional, Serrano, Manuel, additional, Bouwens, Luc, additional, Real, Francisco X., additional, Biankin, Andrew V., additional, and Rooman, Ilse, additional

Published
2013
Full Text
View/download PDF

7. Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial α5 Integrin.

Author

Ying Cao, Hoeppner, Luke H., Bach, Steven, Guangqi E., Yan Guo, Enfeng Wang, Jianmin Wu, Cowley, Mark J., Chang, David K., Waddell, Nicola, Grimmond, Sean M., Biankin, Andrew V., Daly, Roger J., Xiaohui Zhang, and Mukhopadhyay, Debabrata

Subjects
*METASTASIS, *CANCER research, *TUMORS, *ENDOTHELIAL cells, *CANCER cells
Abstract

Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through the bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding the extravasation process or re-entry of circulating tumor cells at metastatic sites. Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF), and other growth factors, expressed on cancer cells interacts with a5 integrin on endothelial cells to mediate vascular extravasation and metastasis in zebrafish and murine xenograft models of clear cell renal cell carcinoma (RCC) and pancreatic adenocarcinoma. In tissue from patients with RCC, NRP-2 expression is positively correlated with tumor grade and is highest in metastatic tumors. In a prospectively acquired cohort of patients with pancreatic cancer, high NRP-2 expression cosegregated with poor prognosis. Through biochemical approaches as well as Atomic Force Microscopy (AFM), we describe a unique mechanism through which NRP-2 expressed on cancer cells interacts with a5 integrin on endothelial cells to mediate vascular adhesion and extravasation. Taken together, our studies reveal a clinically significant role of NRP-2 in cancer cell extravasation and promotion of metastasis. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results