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Your search keyword '"Andersen, Mads Hald"' showing total 9 results
Start Over Author "Andersen, Mads Hald" Journal cancer research
9 results on '"Andersen, Mads Hald"'

3. Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling

Author

Donia, Marco, primary, Harbst, Katja, additional, van Buuren, Marit, additional, Kvistborg, Pia, additional, Lindberg, Mattias F., additional, Andersen, Rikke, additional, Idorn, Manja, additional, Munir Ahmad, Shamaila, additional, Ellebæk, Eva, additional, Mueller, Anja, additional, Fagone, Paolo, additional, Nicoletti, Ferdinando, additional, Libra, Massimo, additional, Lauss, Martin, additional, Hadrup, Sine Reker, additional, Schmidt, Henrik, additional, Andersen, Mads Hald, additional, thor Straten, Per, additional, Nilsson, Jonas A., additional, Schumacher, Ton N., additional, Seliger, Barbara, additional, Jönsson, Göran, additional, and Svane, Inge Marie, additional

Published
2017
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8. Immunogenicity of Constitutively Active V599EBRaf

Author

Andersen, Mads Hald, primary, Fensterle, Joachim, additional, Ugurel, Selma, additional, Reker, Sine, additional, Houben, Roland, additional, Guldberg, Per, additional, Berger, Thomas G., additional, Schadendorf, Dirk, additional, Trefzer, Uwe, additional, Bröcker, Eva-B., additional, Straten, Per thor, additional, Rapp, Ulf R., additional, and Becker, Jürgen C., additional

Published
2004
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9. Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4+ T-Cells, Which Dampen CD8+ T-cell Antitumor Reactivity.

Author

Donia, Marco, Andersen, Rikke, Kjeldsen, Julie W., Fagone, Paolo, Munir, Shamaila, Nicoletti, Ferdinando, Andersen, Mads Hald, Straten, Per thor, and Svane, Inge Marie

Subjects
*MELANOMA, *CANCER cells, *T cells, *CD4 antigen, *TUMORS
Abstract

In the absence of a local inflammatory response, expression of MHC class II molecules is restricted mainly to hematopoietic cells and thymus epithelium. However, certain tumors, such as melanoma, may acquire aberrant constitutive expression of MHC class II. In a set of primary melanoma cell populations and correspondingly expanded autologous tumor-infiltrating lymphocytes (TIL), we show how MHC class II expression on melanoma cells associates with strong MHC class II--restricted CD4+ T-cell responses that are specific for tumors. Notably, we found that tumor-specific CD4+ T-cell responses were dominated by TNF production. TNF reduced CD8+ T-cell activation in IFNg-rich environments resembling a tumor site. Conversely, direct CD4+ T-cell responses had no influence on either the proliferation or viability of melanoma cells. Taken together, our results illustrate a novel immune escape mechanism that can be activated by aberrant expression of MHC class II molecules, which by attracting tumor-specific CD4+ T cells elicit a local inflammatory response dominated by TNF that, in turn, inhibits cytotoxic CD8+ T-cell responses. [ABSTRACT FROM AUTHOR]

Published
2015
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