1. [Evaluation of a series of 137 carcinomas of the endometrium of stage I TNM/UICC]
- Author
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M, Bolla, J, de Cornulier, E, Berland, M, Colonna, X, Artignan, D, Pasquier, J, Salvat, F, Vincent, and H, Kolodié
- Subjects
Adult ,Aged, 80 and over ,Carcinoma ,Middle Aged ,Combined Modality Therapy ,Survival Analysis ,Endometrial Neoplasms ,Myometrium ,Humans ,Female ,Neoplasm Invasiveness ,Lymph Nodes ,Aged ,Neoplasm Staging ,Retrospective Studies - Abstract
To assess retrospectively the long-term results of the combination of surgery and radiotherapy in carcinoma classified cT1.From 1974 to 1993, 137 women suffering from endometrial carcinoma cT1Nx-0 M0 were entered into the study. The median age was 62 years (range: 39-85 years) and the median follow up was 67 months (range: 0-224 months).Surgery was performal in 132 women (96.35%). For cT1, the 5-year overall and specific survivals were 81.1% and 84.5%, respectively. The 10-year overall and specific survivals were 68.8% and 82.2%, respectively. Concerning cT1pT1, the 5-year overall and specific survivals, were 83.9% and 87.4%. The 10-year overall and specific survivals were 71.1% and 85%, respectively. Histological grade, pelvic lymph node involvement and myometrial infiltration influence significantly the overall and specific survivals of cT1pT1 tumors. According to multivariate analysis, pelvic lymph node involvement was a powerful prognostic factor for both the overall and specific survivals. If we rule out pelvic lymph node involvement, WHO histological grade was a significant prognostic factor.Combination of surgery and radiotherapy is still a common procedure for cT1 tumors. When surgery is done before radiotherapy, tailored irradiation may further take place, according to WHO histological grade and pelvic lymph node status.
- Published
- 1999