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Your search keyword '"Yin, Yongmei"' showing total 7 results
Start Over Author "Yin, Yongmei" Journal cancer medicine
7 results on '"Yin, Yongmei"'

1. Nonmetastatic breast cancer patients subsequently developing second primary malignancy: A population‐based study

Author

Bao, Shengnan, primary, Jiang, Mengping, additional, Wang, Xi, additional, Hua, Yijia, additional, Zeng, Tianyu, additional, Yang, Yiqi, additional, Yang, Fan, additional, Yan, Xueqi, additional, Sun, Chunxiao, additional, Yang, Mengzhu, additional, Fu, Ziyi, additional, Huang, Xiang, additional, Li, Jun, additional, Wu, Hao, additional, Li, Wei, additional, Tang, Jinhai, additional, and Yin, Yongmei, additional

Published
2021
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2. Profile, treatment patterns, and influencing factors of anthracycline use in breast cancer patients in China: A nation‐wide multicenter study

Author

Guo, Fengzhu, primary, Yi, Zongbi, additional, Wang, Wenna, additional, Han, Yiqun, additional, Yu, Pei, additional, Zhang, Su, additional, Ouyang, Quchang, additional, Yan, Min, additional, Wang, Xiaojia, additional, Hu, Xichun, additional, Jiang, Zefei, additional, Huang, Tao, additional, Tong, Zhongsheng, additional, Wang, Shusen, additional, Yin, Yongmei, additional, Li, Hui, additional, Yang, Runxiang, additional, Yang, Huawei, additional, Teng, Yuee, additional, Sun, Tao, additional, Cai, Li, additional, Li, Hongyuan, additional, Chen, Xi, additional, He, Jianjun, additional, Liu, Xinlan, additional, Yang, Shune, additional, Fan, Jinhu, additional, Qiao, Youlin, additional, Wang, Jiayu, additional, and Xu, Binghe, additional

Published
2021
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5. Everolimus‐containing therapy vs conventional therapy in the treatment of refractory breast cancer patients with PI3K/AKT/mTOR mutations: A retrospective study

Author

Chen, Zhanhong, primary, Zheng, Yabing, additional, Cao, Wenming, additional, Zhang, Yuzi, additional, Zhao, Zhengyi, additional, Wang, Guoqiang, additional, Zhao, Jing, additional, Cai, Shangli, additional, Shao, Xiying, additional, Huang, Jian, additional, Ye, Weiwu, additional, Huang, Yuan, additional, Li, Wei, additional, Huang, Xiang, additional, Wu, Hao, additional, Wang, Xiaojia, additional, and Yin, Yongmei, additional

Published
2019
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6. Pamiparib dose escalation in Chinese patients with non‐mucinous high‐grade ovarian cancer or advanced triple‐negative breast cancer.

Author

Xu, Binghe, Yin, Yongmei, Dong, Mei, Song, Yan, Li, Wei, Huang, Xiang, Wang, Tongshan, He, Jing, Mu, Xiyan, Li, Li, Mu, Song, Zhang, Wa, and Li, Miao

Subjects
*TRIPLE-negative breast cancer, *OVARIAN cancer, *CHINESE people, *MUCINOUS adenocarcinoma, *HEREDITARY cancer syndromes
Abstract

Background: The recommended phase 2 dose (RP2D) of pamiparib, an investigational PARP1/2 inhibitor, was established as 60 mg twice daily (BID) in a first‐in‐human (FIH) study (NCT02361723). Methods: Chinese patients with advanced non‐mucinous high‐grade ovarian cancer (HGOC) or triple‐negative breast cancer (TNBC) whose disease either progressed despite standard therapy, or for which there is no standard therapy were enrolled in the dose‐escalation (DE) portion of a phase 1/2 study (NCT03333915). The primary endpoint was safety/tolerability; secondary objectives were pharmacokinetics and antitumor activity. BRCA1/2 mutation status was retrospectively evaluated. Results: Nine HGOC and six TNBC patients (N = 15; n = 4, 20 mg; n = 4, 40 mg; n = 7, 60 mg) were enrolled; as of 30 September 2019, one HGOC patient remained on treatment. Seven patients (n = 5, HGOC; n = 2, TNBC) had germline BRCA1/2 mutation (gBRCAmut); all HGOC patients were resistant/refractory to platinum. Asthenia and nausea (n = 12 each) were the most common treatment‐related adverse events (TRAEs). Decreased hemoglobin was the most common grade 3 TRAE (n = 3); no grade ≥4 AEs were observed. No dose‐limiting toxicities (DLTs) were reported. Pamiparib plasma exposure was similar to exposure observed in the FIH study after a single‐dose administration, albeit slightly higher at steady state. Among 13 RECIST‐evaluable patients, two with HGOC (gBRCAmut, n = 1) achieved a confirmed partial response and six with HGOC (gBRCAmut, n = 4) achieved stable disease; all TNBC RECIST‐evaluable patients (n = 5) reported progressive disease. Conclusions: Pamiparib was generally well tolerated in Chinese patients, with durable responses observed in patients with HGOC. Based on these results, pamiparib 60 mg BID was confirmed as the RP2D. [ABSTRACT FROM AUTHOR]

Published
2021
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