1. MCP‐1 expression in breast cancer and its association with distant relapse
- Author
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Bridie S. Mulholland, Pierre Hofstee, Ewan K. A. Millar, Dana Bliuc, Sandra O'Toole, Mark R. Forwood, and Michelle M. McDonald
- Subjects
CCL2 ,metastasis ,neoplasm ,protein ,tumour ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Distant relapse of breast cancer complicates management of the disease and accounts for 90% of breast cancer‐related deaths. Monocyte chemoattractant protein‐1 (MCP‐1) has critical roles in breast cancer progression and is widely accepted as a pro‐metastatic chemokine. Methods This study explored MCP‐1 expression in the primary tumour of 251 breast cancer patients. A simplified ‘histoscore’ was used to determine if each tumour had high or low expression of MCP‐1. Patient breast cancers were retrospectively staged based on available patient data. p
- Published
- 2023
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