1. A greater birthweight increases the risk of acute leukemias in Mexican children—experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)
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Elva Jiménez‐Hernández, Arturo Fajardo‐Gutiérrez, Juan Carlos Núñez‐Enriquez, Jorge Alfonso Martín‐Trejo, Laura Eugenia Espinoza‐Hernández, Janet Flores‐Lujano, José Arellano‐Galindo, Aurora Medina‐Sanson, Rogelio Paredes‐Aguilera, Laura Elizabeth Merino‐Pasaye, Martha Margarita Velázquez‐Aviña, José Refugio Torres‐Nava, Rosa Martha Espinosa‐Elizondo, Raquel Amador‐Sánchez, Juan José Dosta‐Herrera, Javier Anastacio Mondragón‐García, Heriberto Valdés‐Guzmán, Laura Mejía‐Pérez, Gilberto Espinoza‐Anrubio, María Minerva Paz‐Bribiesca, Perla Salcedo‐Lozada, Rodolfo Ángel Landa‐García, Rosario Ramírez‐Colorado, Luis Hernández‐Mora, María Luisa Pérez‐Saldivar, Marlene Santamaría‐Ascencio, Anselmo López‐Loyola, Arturo Hermilo Godoy‐Esquivel, Luis Ramiro García‐López, Alison Ireri Anguiano‐Ávalos, Karina Mora‐Rico, Alejandro Castañeda‐Echevarría, Roberto Rodríguez‐Jiménez, José Alberto Cibrian‐Cruz, Karina Anastacia Solís‐Labastida, Rocío Cárdenas‐Cardos, Armando Martínez‐Avalos, Luz Victoria Flores‐Villegas, José Gabriel Peñaloza‐González, Ana Itamar González‐Ávila, Martha Beatriz Altamirano‐García, Norma López‐Santiago, Martin Sánchez‐Ruiz, Roberto Rivera‐Luna, Luis Rodolfo Rodríguez‐Villalobos, Francisco Hernández‐Pérez, Jaime Ángel Olvera‐Durán, Luis Rey García‐Cortés, Minerva Mata‐Rocha, Omar Alejandro Sepúlveda‐Robles, Cesar Raúl González‐Bonilla, Vilma Carolina Bekker‐Méndez, Silvia Jiménez‐Morales, Haydee Rosas‐Vargas, and Juan Manuel Mejía‐Aranguré
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Birthweight ,children ,epidemiology ,leukemia ,risk factors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract In Mexico, due to the high rates of diabetes, overweight, and obesity, there has also been noted an increased newborn weight, which may be contributing to the elevated incidence rate of childhood acute leukemia (AL). We conducted a case–control study in public hospitals of Mexico City aimed to know whether a greater weight at birth is associated with a higher risk of developing leukemia. We included incident cases with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) diagnosed between 2010 and 2015. Controls were frequency‐matched to the cases by age, sex, and health institution. Logistic regression analysis was performed adjusting risks by child's sex, overcrowding index, birth order, and mother's age at the time of pregnancy. Adjusted odds ratios (aORs) and 95% confidence intervals were calculated. A total of 1455 cases and 1455 controls were included. An evident association between ALL and child's birthweight ≥2500 g was found (aOR 2.06; 95% CI: 1.59, 2.66) and also, in those with birthweight ≥3500 g (aOR 1.19; 95% CI: 1.00, 1.41). In AML patients with birthweight ≥2500 g and ≥3500 g, an aOR of 1.77 (95% CI: 1.07, 2.94) and 1.42 (95% CI: 1.03–1.95) was observed, respectively. No association was noticed with either type of AL and a birthweight ≥4000 g. To sum up, we found a moderate association between not having a low birthweight and an increased risk of acute leukemias. Birthweight ≥3500 g was also a risk factor for both types of leukemia. This suggests that a greater birthweight may increase the risk of acute leukemias in Mexican children.
- Published
- 2018
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