1. Endocrine toxicity of immune checkpoint inhibitors: essential crosstalk between endocrinologists and oncologists.
- Author
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Illouz F, Briet C, Cloix L, Le Corre Y, Baize N, Urban T, Martin L, and Rodien P
- Subjects
- Antibodies, Monoclonal adverse effects, B7-H1 Antigen antagonists & inhibitors, Biomarkers, Tumor, CTLA-4 Antigen antagonists & inhibitors, Clinical Decision-Making, Disease Management, Endocrine System Diseases diagnosis, Endocrine System Diseases etiology, Endocrine System Diseases prevention & control, Endocrine System Diseases therapy, Endocrinologists, Humans, Immunotherapy, Interdisciplinary Communication, Oncologists, Programmed Cell Death 1 Receptor antagonists & inhibitors, Severity of Illness Index, Antineoplastic Agents, Immunological adverse effects, Endocrine System drug effects, Immunomodulation drug effects
- Abstract
Two types of immune checkpoint inhibitors, both antibodies that target cytotoxic T-lymphocyte antigen-4 and those that target programmed cell death-protein 1, have been approved for use in melanoma, non-small-cell lung cancer, and renal cell carcinoma as first-line or second-line therapy. Their adverse events are primarily regarded as immune-related adverse events. We felt it was important to pinpoint and discuss certain preconceptions or misconceptions regarding thyroid dysfunction, hypophysitis, and diabetes induced by immune checkpoint inhibitors. We have identified areas of uncertainty and unmet requirements, including essential interaction between endocrinologists and oncologists. Five issues have been identified for discussion: (1) diagnosis of endocrine toxicity, (2) assessment of toxicity severity, (3) treatment of toxicity, (4) withdrawal or continuation of immunotherapy, (5) preventive action., (© 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
- Published
- 2017
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