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Start Over Author "Hirofumi Adachi" Journal cancer medicine
2 results on '"Hirofumi Adachi"'

1. Impact of somatic mutations on prognosis in resected non‐small‐cell lung cancer: The Japan Molecular Epidemiology for lung cancer study

Author

Akihiro Tamiya, Yasuhiro Koh, Shun‐ichi Isa, Akihito Kubo, Masahiko Ando, Hideo Saka, Naoki Yoshimoto, Sadanori Takeo, Hirofumi Adachi, Tsutomu Tagawa, Osamu Kawashima, Motohiro Yamashita, Kazuhiko Kataoka, Mitsuhiro Takenoyama, Yukiyasu Takeuchi, Katsuya Watanabe, Akihide Matsumura, and Tomoya Kawaguchi

Subjects
next‐generation sequencing, non‐small cell lung cancer, overall survival, recurrence free survival, somatic mutation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To report the follow up data and clinical outcomes of the JME study (UMIN 000008177), a prospective, multicenter, molecular epidemiology examination of 876 surgically resected non‐small‐cell lung cancer (NSCLC) cases, and the impact of somatic mutations (72 cancer‐associated genes) on recurrence‐free survival (RFS) and overall survival (OS). Methods Patients were enrolled between July 2012 and December 2013, with follow up to 30th November 2017. A Cox proportional hazards model was used to assess the impact of gene mutations on RFS and OS, considering sex, smoking history, age, stage, histology, EGFR, KRAS, TP53, and number of coexisting mutations. Results Of 876 patients, 172 had ≥2 somatic mutations. Median follow‐up was 48.4 months. On multivariate analysis, number of coexisting mutations (≥2 vs 0 or 1, HR = 2.012, 95% CI: 1.488‐2.695), age (≥70 vs

Published
2020
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2. Impact of somatic mutations on prognosis in resected non‐small‐cell lung cancer: The Japan Molecular Epidemiology for lung cancer study

Author

Yukiyasu Takeuchi, Mitsuhiro Takenoyama, Yasuhiro Koh, Katsuya Watanabe, Hideo Saka, Kazuhiko Kataoka, Tsutomu Tagawa, Tomoya Kawaguchi, Osamu Kawashima, Akihito Kubo, Motohiro Yamashita, Shun-ichi Isa, Akihiro Tamiya, Sadanori Takeo, Naoki Yoshimoto, Masahiko Ando, Hirofumi Adachi, and Akihide Matsumura

Subjects
Male, 0301 basic medicine, Cancer Research, Lung Neoplasms, Multivariate analysis, next‐generation sequencing, recurrence free survival, Gene mutation, medicine.disease_cause, Gastroenterology, 0302 clinical medicine, Japan, Carcinoma, Non-Small-Cell Lung, somatic mutation, Prospective Studies, Stage (cooking), Pneumonectomy, Original Research, Aged, 80 and over, Molecular Epidemiology, Middle Aged, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Survival Rate, Oncology, 030220 oncology & carcinogenesis, Female, KRAS, Adult, non‐small cell lung cancer, medicine.medical_specialty, overall survival, lcsh:RC254-282, Young Adult, 03 medical and health sciences, Germline mutation, Internal medicine, Biomarkers, Tumor, medicine, Humans, Radiology, Nuclear Medicine and imaging, Lung cancer, Pathological, Aged, Proportional hazards model, business.industry, Clinical Cancer Research, medicine.disease, 030104 developmental biology, Mutation, business, Follow-Up Studies
Abstract

Background To report the follow up data and clinical outcomes of the JME study (UMIN 000008177), a prospective, multicenter, molecular epidemiology examination of 876 surgically resected non‐small‐cell lung cancer (NSCLC) cases, and the impact of somatic mutations (72 cancer‐associated genes) on recurrence‐free survival (RFS) and overall survival (OS). Methods Patients were enrolled between July 2012 and December 2013, with follow up to 30th November 2017. A Cox proportional hazards model was used to assess the impact of gene mutations on RFS and OS, considering sex, smoking history, age, stage, histology, EGFR, KRAS, TP53, and number of coexisting mutations. Results Of 876 patients, 172 had ≥2 somatic mutations. Median follow‐up was 48.4 months. On multivariate analysis, number of coexisting mutations (≥2 vs 0 or 1, HR = 2.012, 95% CI: 1.488‐2.695), age (≥70 vs, A prospective, multi‐center, molecular epidemiology study of 876 surgically resected non‐small cell lung cancer cases, and the impact of somatic mutations (72 cancer‐associated genes) on recurrence‐free survival and overall survival (OS). A smaller number of co‐existing mutations, earlier stage, and younger age were associated with longer recurrence free survival and OS, while epidermal growth factor receptor mutations were significantly associated with improved OS.

Published
2020

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