1. Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
- Author
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Teresa Rojas, Andrew J. Pearson, Nicole Scobie, Leona Knox, Darshan Wariabharaj, Pamela Kearns, Gilles Vassal, Gregory Reaman, Todd Alonzo, Andrea Biondi, Kathy Brodeur‐Robb, Maryam Fouladi, Thomas Gross, Stephen Hunger, Geoff McCowage, Alberto Pappo, Martin Schrappe, Maria Grazia Valsecchi, Brenda Weigel, Peter Wejbora, James Whitlock, Michel Zwaan, Vickie Buenger, Donna Ludwinski, Elly Barry, Kathleen Neville, Anjali Sharma, Dominik Karres, de Rojas, T, Pearson, A, Scobie, N, Knox, L, Wariabharaj, D, Kearns, P, Vassal, G, Reaman, G, Alonzo, T, Biondi, A, Brodeur-Robb, K, Fouladi, M, Gross, T, Hunger, S, Mccowage, G, Pappo, A, Schrappe, M, Grazia Valsecchi, M, Weigel, B, Wejbora, P, Whitlock, J, Zwaan, M, Buenger, V, Ludwinski, D, Barry, E, Neville, K, Sharma, A, and Karres, D
- Subjects
Cancer Research ,medicine.medical_specialty ,Adolescent ,International Cooperation ,Adolescent cancer ,rare disease ,Neoplasms ,Pediatric oncology ,childhood cancer ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Child ,RC254-282 ,Research Articles ,clinical trials ,Clinical Trials as Topic ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Clinical Cancer Research ,rare diseases ,Cancer ,clinical trial ,medicine.disease ,drug development ,Therapeutic trial ,Pediatric cancer ,Clinical trial ,Clinical research ,clinical research ,Oncology ,Drug development ,Family medicine ,international collaboration ,adolescent cancer ,business ,Research Article - Abstract
Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov was systematically searched to identify all clinical therapeutic trials which opened between 2010 and 2020 and recruited pediatric patients (, Intercontinental collaboration is alarmingly rare in childhood cancer trials, despite the rare disease setting and despite pediatric clinical research being inevitably a global enterprise. Barriers to collaboration should be identified and met with specific solutions to accelerate urgently needed drug development for children and adolescents with cancer.
- Published
- 2021
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