1. Prognosis and cure of long-term cancer survivors: A population-based estimation
- Author
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Dal Maso, L., Panato, C., Guzzinati, S., Serraino, D., Francisci, S., Botta, L., Capocaccia, R., Tavilla, A., Gigli, A., Crocetti, E., Rugge, M., Tagliabue, G., Filiberti, R. A., Carrozzi, G., Michiara, M., Ferretti, S., Cesaraccio, R., Tumino, R., Falcini, F., Stracci, F., Torrisi, A., Mazzoleni, G., Fusco, M., Rosso, S., Tisano, F., Fanetti, A. C., Sini, G. M., Buzzoni, C., De Angelis, R., Virdone, S., Gatta, G., Zorzi, M., Mallone, S., Toffolutti, F., Russo, A. G., Caiazzo, A. L., Mangone, L., Mazzucco, W., Pannozzo, F., Ricci, P., Gola, G., Candela, G., Sutera Sardo, A., Dal Maso L., Panato C., Guzzinati S., Serraino D., Francisci S., Botta L., Capocaccia R., Tavilla A., Gigli A., Crocetti E., Rugge M., Tagliabue G., Filiberti R.A., Carrozzi G., Michiara M., Ferretti S., Cesaraccio R., Tumino R., Falcini F., Stracci F., Torrisi A., Mazzoleni G., Fusco M., Rosso S., Tisano F., Fanetti A.C., Sini G.M., Buzzoni C., De Angelis R., Virdone S., Gatta G., Zorzi M., Mallone S., Toffolutti F., Russo A.G., Caiazzo A.L., Mangone L., Mazzucco W., Pannozzo F., Ricci P., Gola G., Candela G., and Sutera Sardo A.
- Subjects
0301 basic medicine ,Oncology ,Male ,Cancer Research ,Time Factors ,Settore MED/42 - Igiene Generale E Applicata ,0302 clinical medicine ,Cancer Survivors ,Prostate ,Neoplasms ,Thyroid cancer ,Original Research ,education.field_of_study ,Relative survival ,Mortality rate ,Middle Aged ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,population-based cancer registrie ,medicine.anatomical_structure ,Italy ,030220 oncology & carcinogenesis ,cancer cure, Italy, population-based cancer registries, prevalence, survival ,Female ,Cancer Prevention ,Adult ,medicine.medical_specialty ,population-based cancer registries ,Adolescent ,Population ,prevalence ,Socio-culturale ,lcsh:RC254-282 ,survival ,03 medical and health sciences ,Young Adult ,Life Expectancy ,Internal medicine ,medicine ,population‐based cancer registries ,Humans ,Radiology, Nuclear Medicine and imaging ,cancer cure ,education ,Aged ,Estimation ,business.industry ,Cancer ,Models, Theoretical ,medicine.disease ,030104 developmental biology ,Life expectancy ,business - Abstract
Background: Increasing evidence of cure for some neoplasms has emerged in recent years. The study aimed to estimate population-based indicators of cancer cure. Methods: Information on more than half a million cancer patients aged 15-74 years collected by population-based Italian cancer registries and mixture cure models were used to estimate the life expectancy of fatal tumors (LEFT), proportions of patients with similar death rates of the general population (cure fraction), and time to reach 5-year conditional relative survival (CRS) >90% or 95% (time to cure). Results: Between 1990 and 2000, the median LEFT increased >1 year for breast (from 8.1 to 9.4 years) and prostate cancers (from 5.2 to 7.4 years). Median LEFT in 1990 was >5 years for testicular cancers (5.8) and Hodgkin lymphoma (6.3) below 45 years of age. In both sexes, it was 95% was 90% was reached in 15 years. Conclusions: The study findings confirmed that several cancer types are curable. The awareness of the possibility of cancer cure has relevant clinical and social impacts. KEYWORDS cancer cure, Italy, population-based cancer registries, prevalence, survival
- Published
- 2019
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