1. Role of treatment on the development of secondary malignancies in patients with essential thrombocythemia
- Author
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Giuliana Alimena, Maria Gabriella Mazzucconi, A Andriani, Massimo Breccia, Cinzia De Gregoris, Michele Cedrone, Erminia Baldacci, Marco Montanaro, Isabella Sperduti, Barbara Anaclerico, Nicoletta Villivà, Raffaele Porrini, Giuseppe Avvisati, Marianna De Muro, Antonio Spadea, Enrico Montefusco, Giuseppe Cimino, Francesca Spirito, Cristina Santoro, Ambra Di Veroli, Roberto Latagliata, Sabrina Leonetti Crescenzi, Angela Rago, and Francesco Buccisano
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Alkylating Agents ,Adolescent ,Population ,Alpha interferon ,alpha‐interferon ,hydroxyurea ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Fibrinolytic Agents ,Internal medicine ,Statistical significance ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Medical history ,secondary malignancy ,education ,Aged ,Original Research ,Aged, 80 and over ,Univariate analysis ,education.field_of_study ,essential thrombocythemia ,Essential thrombocythemia ,business.industry ,Interferon-alpha ,Clinical Cancer Research ,Neoplasms, Second Primary ,Anagrelide ,Middle Aged ,medicine.disease ,Surgery ,Oncology ,030220 oncology & carcinogenesis ,Cohort ,Quinazolines ,anagrelide ,Female ,business ,030215 immunology ,medicine.drug ,Thrombocythemia, Essential - Abstract
Aim of this study is to explore the role of different treatments on the development of secondary malignancies (SMs) in a large cohort of essential thrombocythemia (ET) patients. We report the experience of a regional cooperative group in a real‐life cohort of 1026 patients with ET. We divided our population into five different groups: group 0, no treatment; group 1, hydroxyurea (HU); group 2, alkylating agents (ALK); group 3, ALK + HU sequentially or in combination; and group 4, anagrelide (ANA) and/or α‐interferon (IFN) only. Patients from groups 1, 2, and 3 could also have been treated either with ANA and/or IFN in their medical history, considering these drugs not to have an additional cytotoxic potential. In all, 63 of the 1026 patients (6%) developed 64 SM during the follow‐up, after a median time of 50 months (range: 2–158) from diagnosis. In univariate analysis, a statistically significant difference was found only for gender (P = 0.035) and age (P = 0.0001). In multivariate analysis, a statistically significant difference was maintained for both gender and age (gender HR1.7 [CI 95% 1.037–2.818] P = 0.035; age HR 4.190 [CI 95% 2.308–7.607] P = 0.0001). The impact of different treatments on SMs development was not statistically significant. In our series of 1026 ET patients, diagnosed and followed during a 30‐year period, the different therapies administered, comprising HU and ALK, do not appear to have impacted on the development of SM. A similar rate of SMs was observed also in untreated patients. The only two variables which showed a statistical significance were male gender and age >60 years.
- Published
- 2016